Abstract: A needle cannula for an injection device, extends along a central axis and comprises: a) a skin piercing distal end (133b), b) a proximal end (133a) configured for penetrating a seal structure (102b) of a medicament container (102), and c) a sidewall extending between the skin piercing distal end (133b) and the proximal end (133a), wherein the proximal end (133a) is defined by an angled surface (134) pointing proximally, the angled surface (134) defining a leading portion (134.1) and a heel portion (134.2), and wherein the angled surface (134) comprises a surface portion (134a, 134b) at the heel portion (134.2) forming an angle (?1) between 50 to 75 degrees with respect to the central axis, and further comprises a surface portion (134c) at the leading portion (134.1) forming an angle (?2) between 60 to 85 degrees with respect to the central axis. An injection needle assembly for an injection device and an injection device comprising such assembly are further described.

Abstract: A needle cannula for an injection device, extends along a central axis and comprises: a) a skin piercing distal end (133b), b) a proximal end (133a) configured for penetrating a seal structure (102b) of a medicament container (102), and c) a sidewall extending between the skin piercing distal end (133b) and the proximal end (133a), wherein the proximal end (133a) is defined by an angled surface (134) pointing proximally, the angled surface (134) defining a leading portion (134.1) and a heel portion (134.2), and wherein the angled surface (134) comprises a surface portion (134a, 134b) at the heel portion (134.2) forming an angle (?1) between 50 to 75 degrees with respect to the central axis, and further comprises a surface portion (134c) at the leading portion (134.1) forming an angle (?2) between 60 to 85 degrees with respect to the central axis. An injection needle assembly for an injection device and an injection device comprising such assembly are further described.

Abstract: In a method for applying a curable liquid using an inkjet printing method, a gloss level is controlled by first applying a first layer of liquid and curing the first layer. Having thus obtained a layer having known properties, a second layer is applied on the first layer. Droplets of the second layer are uncured for a predetermined period of time allowing the droplets to spread and coalesce to form a layer having a smooth and flat surface such to provide a desired gloss level, in particular a high gloss. Further, a printing apparatus configured to perform the method is provided.

Abstract: In a method for applying a curable liquid using an inkjet printing method, a gloss level is controlled by first applying a first layer of liquid and curing the first layer. Having thus obtained a layer having known properties, a second layer is applied on the first layer. Droplets of the second layer are uncured for a predetermined period of time allowing the droplets to spread and coalesce to form a layer having a smooth and flat surface such to provide a desired gloss level, in particular a high gloss. Further, a printing apparatus configured to perform the method is provided.

Abstract: Power amplification devices are described, which are configured to amplify a radio frequency (RF) transmission signal. The power amplification device includes a voltage regulation circuit and a power amplification circuit. The voltage regulation circuit is configured to generate a regulated voltage for the power amplification device from a supply voltage and to adjust a regulated voltage level of the regulated voltage in accordance with a voltage adjustment gain. The voltage adjustment gain of the voltage regulation circuit is set by a feedback resistance. To help prevent the voltage regulation circuit from saturating, the voltage regulation circuit adjusts the feedback resistance to reduce the voltage regulation gain.

Abstract: A power amplification device is disclosed that includes a power amplification circuit operable to amplify a radio frequency (RF) signal in accordance with an amplification gain, and a voltage regulation circuit operable to generate a regulated voltage. A regulated voltage level of the regulated voltage sets the amplification gain. To help prevent the voltage regulation circuit from saturating, the voltage regulation circuit is configured to reduce a voltage adjustment gain when the regulated voltage level reaches a threshold voltage level. In one embodiment, the threshold voltage level is set to be higher when a band-select signal indicates that the RF signal is being transmitted within a first frequency band, and is set to be lower when the band-select signal indicates that the RF signal is being transmitted within a second frequency band. The spectral performance of the power amplification device thus improves with regard to the second frequency band.

Abstract: Embodiments of power amplification devices are described that include a power amplification circuit, a first voltage regulation circuit, and a second voltage regulation circuit. The voltage regulation circuits are configured to provide regulated voltages to the power amplification circuit. The power amplification device also includes a threshold detection circuit to get better maximum output power performance while preserving power efficiency. The threshold detection circuit is configured to increase a voltage adjustment gain of the first voltage regulation circuit when a regulated voltage level of regulated voltage from the second voltage regulation circuit reaches a threshold voltage level. In this manner, the voltage adjustment gain can be increased when the second voltage regulation circuit is close to or has railed.

Abstract: A power amplification device is disclosed that includes a power amplification circuit operable to amplify a radio frequency (RF) signal in accordance with an amplification gain, and a voltage regulation circuit operable to generate a regulated voltage. A regulated voltage level of the regulated voltage sets the amplification gain. To help prevent the voltage regulation circuit from saturating, the voltage regulation circuit is configured to reduce a voltage adjustment gain when the regulated voltage level reaches a threshold voltage level. In one embodiment, the threshold voltage level is set to be higher when a band-select signal indicates that the RF signal is being transmitted within a first frequency band, and is set to be lower when the band-select signal indicates that the RF signal is being transmitted within a second frequency band. The spectral performance of the power amplification device thus improves with regard to the second frequency band.

Abstract: Embodiments of power amplification devices are described that include a power amplification circuit, a first voltage regulation circuit, and a second voltage regulation circuit. The voltage regulation circuits are configured to provide regulated voltages to the power amplification circuit. The power amplification device also includes a threshold detection circuit to get better maximum output power performance while preserving power efficiency. The threshold detection circuit is configured to increase a voltage adjustment gain of the first voltage regulation circuit when a regulated voltage level of regulated voltage from the second voltage regulation circuit reaches a threshold voltage level. In this manner, the voltage adjustment gain can be increased when the second voltage regulation circuit is close to or has railed.

Abstract: Power amplification devices are described, which are configured to amplify a radio frequency (RF) transmission signal. The power amplification device includes a voltage regulation circuit and a power amplification circuit. The voltage regulation circuit is configured to generate a regulated voltage for the power amplification device from a supply voltage and to adjust a regulated voltage level of the regulated voltage in accordance with a voltage adjustment gain. The voltage adjustment gain of the voltage regulation circuit is set by a feedback resistance. To help prevent the voltage regulation circuit from saturating, the voltage regulation circuit adjusts the feedback resistance to reduce the voltage regulation gain.

Abstract: Systems and devices for radio frequency (RF) power amplification are disclosed. In one embodiment, a power amplification device includes a power amplification circuit operable to amplify an RF transmission signal and a voltage regulation circuit operable to generate a regulated voltage. The regulated voltage level of the regulated voltage sets an amplification gain of the power amplification circuit. The voltage regulation circuit allows the regulated voltage level closer to the saturation voltage level when a band-select signal indicates that the RF transmission signal is being transmitted within a low transmission frequency band and is further away from the saturation voltage level when the band-select signal indicates that the RF transmission signal is being transmitted within a high transmission frequency band. This provides greater power efficiency when the RF transmission signal is being transmitted with the low transmission frequency band.

Abstract: Embodiments of power amplification devices are described with a power amplification circuit that has more than one amplifier stage and with at least a first voltage regulation circuit and a second voltage regulation circuit configured that provide regulated voltages to these amplifier stages. The power amplification device includes a threshold detection circuit to get better maximum output power performance while preserving power efficiency. The threshold detection circuit is configured to increase a first voltage adjustment gain of the first voltage regulation circuit when a regulated voltage level of a second voltage regulation circuit reaches a first threshold voltage level. In this manner, the first voltage adjustment gain can be initially set to be lower than the second voltage adjustment gain until the second voltage regulation circuit is close or has railed. The first voltage adjustment gain can then be increased to allow the first voltage regulation circuit to also rail.

Abstract: Power amplification devices are described, which are configured to amplify a radio frequency (RF) transmission signal. The power amplification device includes a voltage regulation circuit and a power amplification circuit. The voltage regulation circuit includes a voltage regulator that is operable to generate a regulated voltage from the supply voltage and a feedback circuit that sets a voltage adjustment gain of the voltage regulation circuit. To help prevent the voltage regulation circuit from saturating, the feedback circuit reduces the voltage adjustment gain in response to a voltage difference reaching a threshold voltage level. The voltage difference is between a voltage regulator control signal level of a voltage regulator control signal and the regulated voltage level of the regulated voltage.

Abstract: Embodiments of power amplification devices are described with a power amplification circuit that has more than one amplifier stage and with at least a first voltage regulation circuit and a second voltage regulation circuit configured that provide regulated voltages to these amplifier stages. The power amplification device includes a threshold detection circuit to get better maximum output power performance while preserving power efficiency. The threshold detection circuit is configured to increase a first voltage adjustment gain of the first voltage regulation circuit when a regulated voltage level of a second voltage regulation circuit reaches a first threshold voltage level. In this manner, the first voltage adjustment gain can be initially set to be lower than the second voltage adjustment gain until the second voltage regulation circuit is close or has railed. The first voltage adjustment gain can then be increased to allow the first voltage regulation circuit to also rail.

Abstract: Systems and devices for radio frequency (RF) power amplification are disclosed. In one embodiment, a power amplification device includes a power amplification circuit operable to amplify an RF transmission signal and a voltage regulation circuit operable to generate a regulated voltage. The regulated voltage level of the regulated voltage sets an amplification gain of the power amplification circuit. The voltage regulation circuit allows the regulated voltage level closer to the saturation voltage level when a band-select signal indicates that the RF transmission signal is being transmitted within a low transmission frequency band and is further away from the saturation voltage level when the band-select signal indicates that the RF transmission signal is being transmitted within a high transmission frequency band. This provides greater power efficiency when the RF transmission signal is being transmitted with the low transmission frequency band.

Abstract: Power amplification devices are described, which are configured to amplify a radio frequency (RF) transmission signal. The power amplification device includes a voltage regulation circuit and a power amplification circuit. The voltage regulation circuit includes a voltage regulator that is operable to generate a regulated voltage from the supply voltage and a feedback circuit that sets a voltage adjustment gain of the voltage regulation circuit. To help prevent the voltage regulation circuit from saturating, the feedback circuit reduces the voltage adjustment gain in response to a voltage difference reaching a threshold voltage level. The voltage difference is between a voltage regulator control signal level of a voltage regulator control signal and the regulated voltage level of the regulated voltage.

Abstract: The present invention relates to intercalator pseudonucleotides. Intercalator pseudonucleotides according to the invention are capable of being incorporated into the backbone of a nucleic acid or nucleic acid analogue and they comprise an intercalator comprising a flat conjugated system capable of co-stacking with nucleobases of DNA. The invention also relates to oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudo nucleotide. The invention furthermore relates to methods of synthesising intercalator pseudo nucleotides and methods of synthesising oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudonucleotide.

Abstract: A method of designing and the resulting thermally stable heated coating die apparatus, the die apparatus including a die having a die geometry and a heating system with heaters and temperature sensors. The method and resultant apparatus provides minimized temperature gradients, flat die lip faces in a die to roll plane and a flat die in a plane perpendicular to die flat lip faces and parallel to substrate width. The method optimizes simultaneously: die geometry, placement of the heaters, placement of temperature sensors, and shielding from operating conditions, using heat transfer and structural numerical modeling and statistical analysis while considering die functionality characteristics, minimum increment of temperature measurement and control accuracy related to minimum acceptable deviation from flatness, coating die material of construction relative to thermo-structural material properties, and desirable coating die material properties.

Abstract: Superconducting products on the basis of crystalline superconducting compounds having the general formula (Me.sup.1).sub.p (Me.sup.2).sub.q Cu.sub.3 O.sub.x F.sup.Y, wherein Me.sup.1 is selected from Y, Sc and the lanthanides, Me.sup.2 is Ba and/or Sr, p is 0.8-2.5, q is 0.8-3, x is 5-8.5 and y is 0-6, are prepared by reacting oxides of the metals in the molten phase, the Me.sup.2 oxides at least in part being used as Me.sup.2 peroxide and Me.sup.1 oxide and/or Cu oxide optionally being partly replaced by fluorides. The reaction is carried out under an oxygen-free atmosphere in a closed reaction vessel having deformable walls, and during the reaction the vessel is placed in an autoclave under an isostatic pressure of 800 to 3000 bar and at a temperature of 800.degree. to 1400.degree. C., after which cooling is carried out without opening of the vessel.

Abstract: Protein hormones are fractionated and isolated from extracts of pituitary glands or tissues. Increased yield and purity of the growth hormone is obtained by using controlled amounts of polyethylene glycol as precipitating agent at pH = 4-6, preferably 4.5-5.0 and separating the precipitated fractions.