Patents by Inventor Erik R. Hoefgin

Erik R. Hoefgin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of oripavine as a starting material for buprenorphine
    Patent number: 8993764
    Abstract: There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: March 31, 2015
    Assignee: Mallinckrodt LLC
    Inventors: Anthony Mannino, Erik R. Hoefgin, Lloyd P. Hill, Henry J. Buehler
  • Use of Oripavine as a Starting Material For Buprenorphine
    Publication number: 20080312441
    Abstract: There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.
    Type: Application
    Filed: December 18, 2006
    Publication date: December 18, 2008
    Inventors: Anthony Mannino, Erik R. Hoefgin, Lloyd P. Hill, Henry J. Buehler