Abstract: A pre-chamber ignition system for a spark-ignited reciprocating piston internal combustion engine includes a housing where the housing is installable in a cylinder head of the spark-ignited reciprocating piston internal combustion engine and where the housing has a cavity. An ignition device is disposed in the housing and the ignition device projects into the cavity of the housing. A cover covers the cavity with respect to a combustion chamber of the spark-ignited reciprocating piston internal combustion engine and the cavity and the combustion chamber are connectable together in a gas-guiding manner by an aperture in the cover. The housing consists of a material having a thermal conductivity of more than 170 W/(m*K) and the cover consists of a material having a thermal conductivity of less than 170 W/(m*K).

Abstract: A spark-ignited reciprocating piston internal combustion engine includes a pre-chamber ignition system with a housing which is installed in a cylinder head of the spark-ignited reciprocating piston internal combustion engine. An ignition apparatus is disposed in the pre-chamber ignition system and the ignition apparatus protrudes into a cavity in the housing. The cavity is covered by a cover with respect to a combustion chamber of the spark-ignited reciprocating piston internal combustion engine and the cover has at least one aperture which connects the cavity and the combustion chamber to one another in a gas-conducting manner. The housing has a volume and the at least one aperture has a jet cross section and a ratio of the volume to the jet cross section is greater than 100 and less than 300.

Abstract: A spark-ignited reciprocating piston internal combustion engine includes a pre-chamber ignition system with a housing which is installed in a cylinder head of the spark-ignited reciprocating piston internal combustion engine. An ignition apparatus is disposed in the pre-chamber ignition system and the ignition apparatus protrudes into a cavity in the housing. The cavity is covered by a cover with respect to a combustion chamber of the spark-ignited reciprocating piston internal combustion engine and the cover has at least one aperture which connects the cavity and the combustion chamber to one another in a gas-conducting manner. The housing has a volume and the at least one aperture has a jet cross section and a ratio of the volume to the jet cross section is greater than 100 and less than 300.

Abstract: A pre-chamber ignition system for a spark-ignited reciprocating piston internal combustion engine includes a housing where the housing is installable in a cylinder head of the spark-ignited reciprocating piston internal combustion engine and where the housing has a cavity. An ignition device is disposed in the housing and the ignition device projects into the cavity of the housing. A cover covers the cavity with respect to a combustion chamber of the spark-ignited reciprocating piston internal combustion engine and the cavity and the combustion chamber are connectable together in a gas-guiding manner by an aperture in the cover. The housing consists of a material having a thermal conductivity of more than 170 W/(m*K) and the cover consists of a material having a thermal conductivity of less than 170 W/(m*K).

Abstract: A rope guide for a crane, in particular a rope guide for a telescopic crane, comprises at least one guiding element for a rope which extends from a boom head along the boom of the crane. The guide is characterized in that at least one of the guiding elements comprises a spacer which has, on its rope-sliding surface facing the rope and as viewed transversely to the direction of the rope's extension, a substantially round concave form. Embodiments have a spacer with one or more grooves which guide and accommodate the rope.

Abstract: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins.

Abstract: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins.

Abstract: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins.

Abstract: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins.

Abstract: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins.

Abstract: The present invention relates to methods for detecting and/or measuring the activity of a specific kinase, with the methods comprising contacting one or more kinases with a binding agent to isolate a specific kinase of interest. The isolated kinase is then contacted with a kinase activity sensor, where the kinase activity sensor is comprised of a kinase recognition motif that is capable of being recognized by the isolated kinase, and at least one phosphorylation site. The isolated kinase phosphorylates the amino acid target of the kinase activity sensor and levels of the phosphorylated target amino acid can then be quantified.

Abstract: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins.