Patents by Inventor Erik Schwiebert

Erik Schwiebert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10369145
    Abstract: Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein. Also provided are methods for inhibiting the interaction between two or more heat shock protein chaperones in a cell.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 6, 2019
    Assignee: DISCOVERYBIOMED, INC.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao, Joseph P. Ritchie, Eric C. Seales, Deborah Mai
  • Patent number: 9815825
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis and chronic obstructive pulmonary diseases). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 14, 2017
    Assignee: DiscoveryBiomed, Inc.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao
  • Patent number: 9676779
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: June 13, 2017
    Assignee: DiscoveryBiomed, Inc.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao
  • Patent number: 9546176
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: January 17, 2017
    Assignee: DISCOVERYBIOMED, INC.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao
  • Publication number: 20160038475
    Abstract: Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein. Also provided are methods for inhibiting the interaction between two or more heat shock protein chaperones in a cell.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Applicant: DISCOVERYBIOMED, INC.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao, Joseph P. Ritchie, Eric C. Seales, Deborah Mai
  • Publication number: 20160024065
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis and chronic obstructive pulmonary diseases). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: DISCOVERYBIOMED, INC.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao
  • Publication number: 20150307503
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 29, 2015
    Applicant: DISCOVERYBIOMED, INC.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao
  • Publication number: 20150299206
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 22, 2015
    Applicant: DISCOVERYBIOMED, INC.
    Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao
  • Publication number: 20090175800
    Abstract: This invention relates generally to a method of increasing cytosolic Ca2+ levels in mammalian cells comprising contacting P2X receptor Ca2+ entry channels or any and all other Ca2+ entry channels or mechanisms on the cell with an effective amount of a small molecule, and a composition comprising the small molecule in a delivery system. The invention has broad applicability in the pharmaceutical industry as a method of treating airway diseases (such as cystic fibrosis and asthma), ailments of the lung and airways (such as those caused by common cold pathogens or allergens in allergy), kidney diseases and renal hypertensive disorders (such as polycystic kidney disease and salt-sensitive hypertension syndromes), and endocrine disorders (such as diabetes).
    Type: Application
    Filed: March 16, 2009
    Publication date: July 9, 2009
    Inventors: Erik Schwiebert, Akos Zsembery
  • Patent number: 7524517
    Abstract: This invention relates generally to a method of increasing cytosolic Ca2+ levels in mammalian cells comprising contacting P2X receptor Ca2+ entry channels or any and all other Ca2+ entry channels or mechanisms on the cell with an effective amount of a small molecule, and a composition comprising the small molecule in a delivery system. The invention has broad applicability in the pharmaceutical industry as a method of treating airway diseases (such as cystic fibrosis and asthma), ailments of the lung and airways (such as those caused by common cold pathogens or allergens in allergy), kidney diseases and renal hypertensive disorders (such as polycystic kidney disease and salt-sensitive hypertension syndromes), and endocrine disorders (such as diabetes).
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: April 28, 2009
    Assignee: UAB Research Foundation
    Inventors: Erik Schwiebert, Akos Zsembery
  • Publication number: 20060121128
    Abstract: This invention relates generally to a method of increasing cytosolic Ca2+ levels in mammalian cells comprising contacting P2X receptor Ca2+ entry channels or any and all other Ca2+ entry channels or mechanisms on the cell with an effective amount of a small molecule, and a composition comprising the small molecule in a delivery system. The invention has broad applicability in the pharmaceutical industry as a method of treating airway diseases (such as cystic fibrosis and asthma), ailments of the lung and airways (such as those caused by common cold pathogens or allergens in allergy), kidney diseases and renal hypertensive disorders (such as polycystic kidney disease and salt-sensitive hypertension syndromes), and endocrine disorders (such as diabetes).
    Type: Application
    Filed: January 20, 2004
    Publication date: June 8, 2006
    Inventors: Erik Schwiebert, Akos Zsembery
  • Publication number: 20060075353
    Abstract: Described is a system and method that provide an organized view of computer content clippings including text, documents, pictures, and other file types. The clippings are persisted with associated metadata that enables the users to access the clippings in a managed manner via filtering and sorting mechanisms that allow the user to view clippings sorted and/or filtered based on the metadata. The metadata includes originating application information, originating document information, and date and size information. The user can assign categories or projects to the clippings to organize various clippings for a future project to be created from the clippings, assign keywords, and give the clipping a title. The present invention thus allows users to maintain a large database of useful clippings that can be reused in different documents.
    Type: Application
    Filed: September 29, 2004
    Publication date: April 6, 2006
    Applicant: Microsoft Corporation
    Inventors: Stuart DeSpain, Erik Schwiebert