Patents by Inventor Erik Thai
Erik Thai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8852163Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: GrantFiled: June 28, 2013Date of Patent: October 7, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
-
Patent number: 8845629Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.Type: GrantFiled: April 5, 2010Date of Patent: September 30, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Demarais, Nicolas Zadno, Benjamin J. Clark, Erik Thai, Howard R. Levin, Mark Gelfand
-
Patent number: 8818514Abstract: Methods for intravascularly-induced renal neuromodulation. In some embodiments, a method can include positioning a pair of bipolar electrodes within renal vasculature of a human patient and expanding a balloon within the renal vasculature. The method can further include delivering an electric field via the bipolar electrodes.Type: GrantFiled: July 2, 2013Date of Patent: August 26, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Zarins, Nicolas Zadno, Benjamin J. Clark, Erik Thai
-
Patent number: 8808345Abstract: The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.Type: GrantFiled: April 13, 2010Date of Patent: August 19, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Benjamin J. Clark, William R. George, Kenneth J. Michlitsch, John Paul Sam, Erik Thai, Andrew Wu
-
Publication number: 20140228739Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: ApplicationFiled: April 22, 2014Publication date: August 14, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
-
Patent number: 8784463Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.Type: GrantFiled: February 12, 2013Date of Patent: July 22, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Zarins, Nicolas Zadno, Benjamin J. Clark, Erik Thai, Howard R. Levin, Mark Gelfand
-
Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
Patent number: 8777942Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: October 22, 2010Date of Patent: July 15, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai -
Patent number: 8774913Abstract: Methods and apparatus are provided for intravascularly-induced neuromodulation or denervation. Neuromodulation may be achieved via direct and/or via indirect application of energy or neuromodulatory agents to target neural matter, or to vascular structures that support the target neural matter. In some embodiments, parameters of the target neural matter, of non-target tissue, or of the apparatus may be monitored via one or more sensors for controlling the neuromodulation or denervation. Such monitoring data optionally may be utilized for feedback control of the neuromodulation or denervation.Type: GrantFiled: November 14, 2006Date of Patent: July 8, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Demarais, Hanson Gifford, III, Mark Deem, Douglas Sutton, Erik Thai, Benjamin J. Clark, Nicolas Zadno
-
Patent number: 8768470Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: GrantFiled: May 11, 2010Date of Patent: July 1, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark Deem, Hanson Gifford, III, Denise Demarais, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
-
Patent number: 8728075Abstract: Multi-directional deflectable catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: August 30, 2010Date of Patent: May 20, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai, Kenneth J. Michlitsch, Mark S. Leung
-
Patent number: 8728138Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.Type: GrantFiled: February 12, 2013Date of Patent: May 20, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Zarins, Nicolas Zadno, Benjamin J. Clark, Erik Thai, Howard R. Levin, Mark Gelfand
-
Patent number: 8728137Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.Type: GrantFiled: February 12, 2013Date of Patent: May 20, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Zarins, Nicolas Zadno, Benjamin J. Clark, Erik Thai, Howard R. Levin, Mark Gelfand
-
Patent number: 8702679Abstract: Interventional catheter-based systems and methods are described herein for use in generating an initial pathway through vascular occlusions. The catheter systems generally include two elements. A first element is a Blunt Dissection Catheter including a manually actuated assembly located at the distal tip of the Blunt Dissection Catheter that performs blunt dissection in the vascular occlusion to produce a dissection track, or small pathway through the occlusion. The second element is a Sheath Catheter that serves as a conduit within which the Blunt Dissection Catheter is freely advanced, retracted and rotated. The first and second elements are used in some combination to cross vascular occlusions in both the coronary and peripheral vasculature.Type: GrantFiled: June 10, 2004Date of Patent: April 22, 2014Inventors: Robert K. Deckman, Erik Thai, Amiel R. Aguilar, Benjamin J. Clark, Sergio Salinas, Daniel E. Francis, Kurt D. Sparks
-
Patent number: 8684998Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.Type: GrantFiled: March 9, 2012Date of Patent: April 1, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Denise Demarais, Nicolas Zadno, Benjamin J. Clark, Erik Thai, Howard R. Levin, Mark Gelfand
-
Publication number: 20140081259Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: ApplicationFiled: October 17, 2013Publication date: March 20, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
-
Publication number: 20140058377Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: ApplicationFiled: October 17, 2013Publication date: February 27, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
-
Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
Patent number: 8652129Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: August 21, 2009Date of Patent: February 18, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai -
Publication number: 20140018723Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: ApplicationFiled: June 28, 2013Publication date: January 16, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
-
Publication number: 20140012258Abstract: Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g.Type: ApplicationFiled: July 2, 2013Publication date: January 9, 2014Inventors: Denise Demarais, Nicolas Zadno, Benjamin J. Clark, Erik Thai
-
Patent number: 8548600Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.Type: GrantFiled: September 14, 2012Date of Patent: October 1, 2013Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark Deem, Hanson Gifford, III, Denise Demarais, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin