Patents by Inventor Erik Yusko

Erik Yusko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230382979
    Abstract: Provided are antibodies that specifically bind a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antigen. Nucleic acids that encode one or both of the variable chain polypeptides of an antibody of the present disclosure are also provided, as are cells that include such nucleic acids. Also provided are compositions that include the antibodies of the present disclosure, including in some instances, pharmaceutical compositions. Methods of making and using the antibodies of the present disclosure are also provided. In certain aspects, provided are methods that include administering to an individual in need thereof, e.g., an individual having or suspected of having a SARS-CoV-2 infection, a therapeutically effective amount of an antibody of the present disclosure.
    Type: Application
    Filed: October 29, 2021
    Publication date: November 30, 2023
    Inventors: Erik Yusko, Peter J. R. Ebert, Amy Gilbert, Gladys Keitany, Mark Klinger, Ben Rubin
  • Patent number: 10670578
    Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: June 2, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Michael Mayer, Erik Yusko, Jerry Yang
  • Patent number: 10656117
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: May 19, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Michael Mayer, Erik Yusko
  • Publication number: 20190323990
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.
    Type: Application
    Filed: June 10, 2019
    Publication date: October 24, 2019
    Inventors: Michael MAYER, Erik YUSKO
  • Publication number: 20190234930
    Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Inventors: Michael MAYER, Erik YUSKO, Jerry YANG
  • Patent number: 10317361
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: June 11, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Michael Mayer, Erik Yusko
  • Patent number: 10254271
    Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: April 9, 2019
    Assignee: The Regents of The University of Michigan
    Inventors: Michael Mayer, Erik Yusko, Jerry Yang
  • Publication number: 20170138898
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, ad dipole moment are derived from the measurements.
    Type: Application
    Filed: January 26, 2017
    Publication date: May 18, 2017
    Inventors: Michael Mayer, Erik Yusko
  • Patent number: 9557292
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, ad dipole moment are derived from the measurements.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: January 31, 2017
    Assignee: The Regents Of The University Of Michigan
    Inventors: Michael Mayer, Erik Yusko
  • Publication number: 20170023544
    Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
    Type: Application
    Filed: May 18, 2016
    Publication date: January 26, 2017
    Inventors: Michael Mayer, Erik Yusko, Jerry Yang
  • Patent number: 9347929
    Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid lipid walls. The fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: May 24, 2016
    Assignee: The Regents Of The University Of Michigan
    Inventors: Michael Mayer, Erik Yusko, Jerry Yang
  • Publication number: 20140246317
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, ad dipole moment are derived from the measurements.
    Type: Application
    Filed: February 24, 2014
    Publication date: September 4, 2014
    Inventors: Michael MAYER, Erik Yusko
  • Publication number: 20130048499
    Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid lipid walls. The fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
    Type: Application
    Filed: February 20, 2012
    Publication date: February 28, 2013
    Applicant: The Regents of the University of Michigan
    Inventors: Michael Mayer, Erik Yusko, Jerry Yang