Patents by Inventor Eriko Ito
Eriko Ito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240083939Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: November 9, 2023Publication date: March 14, 2024Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20230255230Abstract: An object of the present invention is to provide an ingredient-stuffed soft candy that provides both of the texture of an ingredient felt during eating and the feeling of integration between the ingredient and a soft candy dough, and the shape retainability of the soft candy and to provide a soft candy that can provide a natural juicy feeling coming from the ingredient. The ingredient-stuffed soft candy includes an ingredient, a center dough containing the ingredient, and an outer-layer dough covering the center dough, in which the ingredient has a hardness of 1050 g or less at normal temperature, and the hardness of the center dough at normal temperature is relatively lower than the hardness of the outer-layer dough at normal temperature.Type: ApplicationFiled: June 25, 2021Publication date: August 17, 2023Applicant: Morinaga & Co., Ltd.Inventors: Miku SUZUKI, Yoko SUZUKI, Eriko ITO, Takahiro YAMAGUCHI, Ryosuke KERA
-
Publication number: 20230227498Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: March 31, 2023Publication date: July 20, 2023Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20230210690Abstract: A medicine administration tool configured for use in a transocular iontophoresis device for forming an electric circuit between a first electrode and a second electrode and supplying medicine to an eyeball, includes: a tubular member having a first lower end configured to face the eyeball; an inner member having a second lower end configured to face the eyeball, the inner member being accommodated in a space of the tubular member and forming a medicine accommodating chamber for accommodating the medicine between the inner member and the tubular member; and a support member movably supporting the inner member with respect to the tubular member.Type: ApplicationFiled: February 24, 2023Publication date: July 6, 2023Applicant: TERUMO KABUSHIKI KAISHAInventors: Yoshihisa SHIMAMURA, Yusuke HYAKKAN, Ryo TANAKA, Eriko ITO, Yoichiro IWASE
-
Publication number: 20220389054Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: August 23, 2022Publication date: December 8, 2022Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20220135618Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: January 13, 2022Publication date: May 5, 2022Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20210292360Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: June 2, 2021Publication date: September 23, 2021Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20210122812Abstract: The present inventors discovered that incorporating an Fc region and an antigen-binding domain whose antigen-binding activity varies depending on ion concentration into an antigen-binding molecule that binds to an aggregate-forming antigen produces an antigen-binding molecule that can preferentially clear protein aggregates in comparison to protein monomers from plasma. Use of antigen-binding molecules of the present invention allows various diseases stemming from target tissues to be treated target-tissue-specifically. Use of antigen-binding molecules of the present invention enables treatment of diseases caused by protein aggregates.Type: ApplicationFiled: January 8, 2021Publication date: April 29, 2021Inventors: Tomoyuki Igawa, Naoka Hironiwa, Eriko Ito
-
Publication number: 20210060254Abstract: A hollow medical needle is disclosed which includes: a hub part having an inner cavity connectable to a syringe; and a puncture part extending out toward an axial distal-end side of the hub part, by forming, at a distal end of the hub part, a puncture index part that includes a step perpendicular to an axial direction and is visible when abutting against a rubber stopper when the rubber stopper of a vial container is punctured by the puncture part, a position of an insertion terminal end substantially coincident with an outer surface of the rubber stopper is set at a fixed position when the puncture part is punctured into the rubber stopper.Type: ApplicationFiled: November 11, 2020Publication date: March 4, 2021Applicant: TERUMO KABUSHIKI KAISHAInventors: Minami MAEKAWA, Eriko ITO, Yoichiro IWASE, Toshiaki TAKAKI
-
Publication number: 20210040147Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: October 22, 2020Publication date: February 11, 2021Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20200207805Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: March 11, 2020Publication date: July 2, 2020Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20190352334Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: June 21, 2019Publication date: November 21, 2019Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20190062368Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: October 9, 2018Publication date: February 28, 2019Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20180162902Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: January 19, 2018Publication date: June 14, 2018Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20170275332Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: June 8, 2017Publication date: September 28, 2017Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20150353630Abstract: The present inventors discovered that incorporating an Fc region and an antigen-binding domain whose antigen-binding activity varies depending on ion concentration into an antigen-binding molecule that binds to an aggregate-forming antigen produces an antigen-binding molecule that can preferentially clear protein aggregates in comparison to protein monomers from plasma. Use of antigen-binding molecules of the present invention allows various diseases stemming from target tissues to be treated target-tissue-specifically. Use of antigen-binding molecules of the present invention enables treatment of diseases caused by protein aggregates.Type: ApplicationFiled: May 30, 2013Publication date: December 10, 2015Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Tomoyuki Igawa, Naoka Hironiwa, Eriko Ito
-
Publication number: 20130018174Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.Type: ApplicationFiled: December 24, 2010Publication date: January 17, 2013Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Zenjiro Sampei, Tetsuya Wakabayashi, Eriko Ito
-
Publication number: 20100261401Abstract: The present invention relates to a toy figure around which textiles can be wrapped and attached comprising: at least one opening formed on a surface of said toy figure, an elastic member formed to cover each opening wherein a wavy incision is formed on each elastic member and the elastic member is exposed and visible from the opening.Type: ApplicationFiled: June 18, 2010Publication date: October 14, 2010Inventors: Mariko Takano, Midori Itou, Saki Kawai, Yoshitaka Shido, Eriko Ito, Sayaka Kuroda, Danielle N. Armbrust, Penny Christine Towne-Vowles, Veronica Sandoval
-
Patent number: 7778625Abstract: An operation-mode control unit controls switching of an operation mode of a portable wireless terminal apparatus between a normal mode and an alarm mode. An alarm-data sending unit sends data pertaining to a situation of a user to a predetermined destination as alarm data, when the operation mode is switched to the alarm mode. In the normal mode, the portable wireless terminal apparatus performs normal functions, such as a phone call and an e-mail. In the alarm mode, the portable wireless terminal apparatus performs a user protecting function in addition to the normal functions, such as sending the alarm data to the predetermined destination.Type: GrantFiled: October 31, 2005Date of Patent: August 17, 2010Assignee: Fujitsu LimitedInventors: Osamu Yamauchi, Masahiro Harima, Atsushi Ito, Eriko Ito
-
Publication number: 20090083658Abstract: According to an aspect of an embodiment, a portable terminal having a display screen for displaying a plurality of emails on the display screen, the portable terminal includes: a receiving module for receiving a plurality of emails each having a body; a first display processing module for displaying the body of the email on the display screen; a detector for detecting the last of the body displayed on the display screen; and a second display processing module for displaying on the display screen a list of the plurality of the emails and status of each of the emails indicating whether the last of the body of each of the emails has been displayed.Type: ApplicationFiled: September 18, 2008Publication date: March 26, 2009Applicant: FUJITSU LIMITEDInventors: Atsushi ITO, Iriichi OSANAI, Eriko ITO