Patents by Inventor Eriko Nukui

Eriko Nukui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide derivatives
    Patent number: 6228841
    Abstract: Compounds represented by the following general formula and salts thereof; Y-L-Tyr-Q-NR1—CH(R2)—CO—X, wherein R1 represents hydrogen or C1-6 alkyl; R2 represents optionally substituted benzyl; Q represents D- or L-Arg; Y represents two hydrogen atoms of N-terminal amino group of L-Tyr, or one or two functional groups substituting for the hydrogen atoms, for example, a C1-6 alkyl optionally having amino or carboxy; and X represents N-methyl-&bgr;-alanine and other. The compounds have analgesic effect and can be used for the treatment of cancer pain or the like.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: May 8, 2001
    Assignees: Daiichi Pharmaceutical Co., Ltd., Fuji Chemical Industries, Ltd.
    Inventors: Shinobu Sakurada, Toru Okayama, Eriko Nukui, Kazuya Hongo, Tadashi Ogawa, Tomoko Hongo, Satoko Takeshima, Nobuhiro Take, Masaharu Nakano
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5880258
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-D-Tyr(R) Tyr(R) (I)?In the formula, A represents Glu or Pro, R represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 9, 1999
    Assignees: Japan Energy Corporation, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Ryo Muramatsu, Akiko Sukesada, Satoru Misawa, Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5767235
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) (I)?In the formula, A represents Glu or Pro, B represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 16, 1998
    Assignees: Nippon Mining Company Limited, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi, Ryo Muramatsu, Akiko Sukesada, Satoru Misawa