Patents by Inventor Eriks Rozners

Eriks Rozners has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for recognition of RNA using triple helix forming peptide nucleic acids
    Patent number: 10385100
    Abstract: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: August 20, 2019
    Assignee: The Research Foundation for the State University o
    Inventors: Eriks Rozners, Thomas Zengeya
  • Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
    Patent number: 10260089
    Abstract: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: April 16, 2019
    Assignee: The Research Foundation of The State University of New York
    Inventors: Eriks Rozners, Thomas Zengeya
  • COMPOSITIONS AND METHODS FOR RECOGNITION OF RNA USING TRIPLE HELICAL PEPTIDE NUCLEIC ACIDS
    Publication number: 20170009280
    Abstract: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.
    Type: Application
    Filed: July 27, 2016
    Publication date: January 12, 2017
    Inventors: Eriks Rozners, Thomas Zengeya
  • COMPOSITIONS AND METHODS FOR RECOGNITION OF RNA USING TRIPLE HELICAL PEPTIDE NUCLEIC ACIDS
    Publication number: 20140206838
    Abstract: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.
    Type: Application
    Filed: October 29, 2013
    Publication date: July 24, 2014
    Applicant: The Research Foundation for The State University of New York
    Inventors: Eriks Rozners, Thomas Zengeya