Abstract: The present invention relates to the use of which are attached or anchored phospholipid biolayers further modified by CRLF-2 and CD 19 binding peptides which may be used for delivering pharmaceutical cargos, to cells expressing CRLF-2 and CD 19, thereby treating cancer, in particular, acute lymphoblastic leukemia (ALL), including (B-precursor acute lymphoblastic leukemia (B-ALL). Novel CRLF-2 binding peptides and CLRF-2 and CD19-binding viral-like particles (VLPs) useful in the treatment of cancer, including ALL are also provided.

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g.

Abstract: A system and method for waking a person includes the provision of tactile stimulation in a repeating interrupted pattern upon the detection of an alarm signal indicative of an event for which the person should be awakened. In one embodiment, a device for waking a person comprises a circuit for generating a driver signal in response to an alarm signal, the driver signal having a repeating interrupted pattern; an electrically controlled switching device having a control input, a power input and a power output, the power input being connectable to a power source, the control input being connected to receive the driver signal from the circuit; and a tactile stimulation device connected to the power output of the electrically controlled switching device, the tactile stimulation device being configured to produce a tactile stimulation.

Abstract: A system and method for waking a person includes the provision of tactile stimulation in a repeating interrupted pattern upon the detection of an alarm signal indicative of an event for which the person should be awakened. In one embodiment, a device for waking a person comprises a circuit for generating a driver signal in response to an alarm signal, the driver signal having a repeating interrupted pattern; an electrically controlled switching device having a control input, a power input and a power output, the power input being connectable to a power source, the control input being connected to receive the driver signal from the circuit; and a tactile stimulation device connected to the power output of the electrically controlled switching device, the tactile stimulation device being configured to produce a tactile stimulation.