Abstract: The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.

Abstract: Disclosed are various embodiments providing automated management of security operations centers. In one embodiment, a correlation and decision engine correlates event data generated by a plurality of monitoring services with a plurality of alerts generated by a plurality of threat intelligence services. The engine then adjusts at least one rule of one or more threat intelligence services with respect to at least one event based at least in part on a corresponding frequency of at least one of the plurality of alerts meeting a threshold, where the adjusted alert(s) are associated with the event(s).

Abstract: A polarization conversion system includes a geometric phase element and a retarder element. The geometric phase element has optical anisotropy with local optical axis orientations that vary non-linearly in at least one dimension along a surface thereof. The retarder element is arranged to receive light output from the geometric phase element. Related systems and methods are also discussed.

Abstract: A polarization conversion system includes a geometric phase element and a retarder element. The geometric phase element has optical anisotropy with local optical axis orientations that vary non-linearly in at least one dimension along a surface thereof. The retarder element is arranged to receive light output from the geometric phase element. Related systems and methods are also discussed.