Abstract: A method and a distributed architecture for controlling functions of an aircraft comprising: a controller, an Input/Output (IO) node and a processor configured to display a graphical user interface component representing at least a portion of an aircraft cabin divided into at least two sections on the IO node and receive, by the IO node, a first and a second input from a user for selecting one of the at least two sections and selecting a preset of at least one controllable parameter respectively. Upon determining that the user requests a modification of the selected preset for the selected section, a preset setting menu including the at least one controllable parameter associated with the selected preset is displayed; a third input from the user for modifying the at least one controllable parameter is received and a modified preset based on the modified at least one controllable parameter is generated.

Abstract: Provided herein is a composition containing a hydrogenated blend of a semi-crystalline, selectively hydrogenated block copolymer, a selectively diblock copolymers lacking semi-crystalline blocks, and a low polarity fluid for cable filling applications. The block copolymer comprises blocks of semi-crystalline hydrogenated polybutadiene, blocks of poly(mono alkenyl arenes), and blocks of hydrogenated, non-crystalline conjugated dienes. The diblock copolymer comprises blocks of poly(mono alkenyl arenes) and blocks of non-crystalline poly(conjugated diene(s)). The compositions can be converted to non-flowable gels and find application as fillers for cables such as fiber optic cables.

Abstract: A method of operation for a system incorporating a graphical user interface in a mobile computing device for a crew member within a cabin of an aircraft. The method includes displaying a menu for at least one controllable parameter, receiving a selection of the controllable parameter, displaying at least one control for the selected controllable parameter, receiving a control input for the selected controllable parameter, and adjusting the selected controllable parameter consistent with the control input. The controllable parameter include a plurality of controllable parameters selected from a group encompassing light intensity, light color, temperature, and the degree of openness of at least one window shade. A system and executable computer program product also are provided.

Abstract: A method and a distributed architecture for representing a location of a fault in an aircraft cabin, comprising: a controller operatively connected to a processor; a crew IO node operatively connected to the controller; the processor being configured to perform: detecting, by the controller, that an event of a system of the aircraft cabin corresponding to a fault has occurred; determining, by the processor, which aircraft cabin section amongst a plurality of aircraft cabin sections is associated with the system for which the event corresponding to the fault has occurred; and displaying, on the crew IO node, (i) a graphical user interface (GUI) component representing at least a portion of the aircraft cabin comprising at least some of the plurality of aircraft cabin sections and (ii) a visual indication identifying the aircraft cabin section associated with the system for which the event corresponding to the fault has occurred.

Abstract: Provided herein is a dispersion composition comprising a blend of a semi-crystalline, selectively hydrogenated block copolymer and a low polarity fluid for oilfield applications. The block copolymer comprises blocks of semi-crystalline hydrogenated polybutadiene, blocks of poly(mono alkenyl arenes), and blocks of hydrogenated, non-crystalline conjugated dienes. The dispersions can be converted to thixotropic fluids or cohesive gels and find application as insulating packer fluids, fluid loss pills, drilling fluids and completion fluids.

Abstract: Provided herein is a composition containing a hydrogenated blend of a semi-crystalline, selectively hydrogenated block copolymer, a selectively diblock copolymers lacking semi-crystalline blocks, and a low polarity fluid for cable filling applications. The block copolymer comprises blocks of semi-crystalline hydrogenated polybutadiene, blocks of poly(mono alkenyl arenes), and blocks of hydrogenated, non-crystalline conjugated dienes. The diblock copolymer comprises blocks of poly(mono alkenyl arenes) and blocks of non-crystalline poly(conjugated diene(s)). The compositions can be converted to non-flowable gels and find application as fillers for cables such as fiber optic cables.

Abstract: Provided herein is a dispersion composition comprising a blend of a semi-crystalline, selectively hydrogenated block copolymer and a low polarity fluid for oilfield applications. The block copolymer comprises blocks of semi-crystalline hydrogenated polybutadiene, blocks of poly(mono alkenyl arenes), and blocks of hydrogenated, non-crystalline conjugated dienes. The dispersions can be converted to thixotropic fluids or cohesive gels and find application as insulating packer fluids, fluid loss pills, drilling fluids and completion fluids.

Abstract: The present disclosure describes PD-L1 gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.

Abstract: The present disclosure describes gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.

Abstract: The present disclosure describes IFN-? gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.

Abstract: The invention relates to a selectively hydrogenated isoprene-styrene diblock copolymer having a polystyrene content of at least 40 wt. %, which when added to an oil-based mud composition, substantially reduces fluid loss. The polystyrene in the diblock has a true molecular weight greater than 60 kg/mole and the total apparent molecular weight of the diblock copolymer is at least 160 kg/mole. The drilling mud that contains about 0.5 pounds per barrel to about 10 pounds per barrel of a selectively hydrogenated isoprene-styrene diblock copolymer and a weighting agent, resulting in a drilling fluid composition exhibiting good suspension of the weighting agent and improved fluid loss performance.

Abstract: A method of operation for a system incorporating a graphical user interface in a mobile computing device for a crew member within a cabin of an aircraft. The method includes displaying a menu for at least one controllable parameter, receiving a selection of the controllable parameter, displaying at least one control for the selected controllable parameter, receiving a control input for the selected controllable parameter, and adjusting the selected controllable parameter consistent with the control input. The controllable parameter include a plurality of controllable parameters selected from a group encompassing light intensity, light color, temperature, and the degree of openness of at least one window shade. A system and executable computer program product also are provided.

Abstract: The present invention relates to a synthetic cement that comprises a low viscosity monofunctional monomer, a dicyclopentadienyl moiety having a pendant free radical reactive species, 1,3-butyleneglycol dimethacrylate, unsaturated styrenic block copolymer, and a peroxide curing agent. Additionally it may include weighting agents depending on the circumstances of the well, as is well known to those skilled in the art. Other additional components such as oil based mud, suspending agents, Portland cement, acrylates and methacrylates, retardant curing additives, and clays may optionally be incorporated into the synthetic cement. The synthetic cement is activated by heat, for example, and can be crafted to set within a certain time frame, for example in 4 hours, so that it pumpable for as long as need be, and then be set to seal the well in the manner desired.

Abstract: The invention relates to a selectively hydrogenated isoprene-styrene diblock copolymer having a polystyrene content of at least 40 wt. %, which when added to an oil-based mud composition, substantially reduces fluid loss. The polystyrene in the diblock has a true molecular weight greater than 60 kg/mole and the total apparent molecular weight of the diblock copolymer is at least 160 kg/mole. The drilling mud that contains about 0.5 pounds per barrel to about 10 pounds per barrel of a selectively hydrogenated isoprene-styrene diblock copolymer and a weighting agent, resulting in a drilling fluid composition exhibiting good suspension of the weighting agent and improved fluid loss performance.

Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.

Abstract: The present invention relates to a synthetic cement that comprises a low viscosity monofunctional monomer, a dicyclopentadienyl moiety having a pendant free radical reactive species, 1,3-butyleneglycol dimethacrylate, unsaturated styrenic block copolymer, and a peroxide curing agent. Additionally it may include weighting agents depending on the circumstances of the well, as is well known to those skilled in the art. Other additional components such as oil based mud, suspending agents, Portland cement, acrylates and methacrylates, retardant curing additives, and clays may optionally be incorporated into the synthetic cement. The synthetic cement is activated by heat, for example, and can be crafted to set within a certain time frame, for example in 4 hours, so that it pumpable for as long as need be, and then be set to seal the well in the manner desired.

Abstract: A Developmental Pacifier is provided to help infants with functional feeding development and to assist with specific developmental problems in young children such as developmental delays, prematurity, gastro-esophageal reflux, autism spectrum disorder, hypotonicity, cerebral palsy, Down's syndrome, microcephaly, and other sensory integrative dysfunctions. The developmental pacifier of the present invention encourages acceptance of food textures and stimulates oral-motor awareness, and reduces or eliminates functional feeding problems in children. The Developmental Pacifier has a nipple with an upper portion and a base portion, a base, and sensory elements. A series of Developmental Pacifiers with varying sensory elements may be used for certain treatment regimens as prescribed by a medical practitioner, pediatric occupational therapist, or other pediatric specialist.

Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.

Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.

Abstract: Devices and methods for use in detecting an optical signal, such as from a fluorescent agent, and converting it to a visible signal are provided. Aspects of the devices include a first light source that emits light onto a region of interest such as a body tissue, body fluid, or agent such as a fluorescent agent introduced into the body; a detector for detecting light emitted or reflected from the region of interest; and a visible light source that emits visible light onto the region of interest, where the color or intensity of the visible light is selected based on the amount of light at one or more wavelengths detected by the detector. Devices and methods of the invention find use in a variety of applications, such as in applications in which it is desired to identify an anatomical structure during surgery, without the need to eliminate ambient light.