Abstract: Activators of Kv3.1 and/or Kv3.2 channels which are therapeutically useful in the treatment of cognitive dysfunction and the negative symptoms which are associated with central nervous system disorders such as schizophrenia, Alzheimer's disease, Tourette's syndrome, autism, dementia, epilepsy and other disorders where gamma oscillations are dysfunctional are provided. The activators include substituted N-heteroaryl compounds.

Abstract: The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

Abstract: The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

Abstract: The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

Abstract: A coupler removably connectable to a decorating bag. The coupler includes an inner coupler configured to be inserted into the decorating bag, an outer coupler configured to removably secure to the inner coupler with the decorating bag disposed between the inner coupler and the outer coupler and a retainer configured to receive a decorating tip and removably secure to the outer coupler in order to lock the decorating tip into position.

Abstract: A support device for moving an item on a surface. A main body includes a panel and a sidewall. A handle assembly engages the main body and includes a first transportation mechanism. The support device includes a resistance portion on the main body for engaging a surface and resisting movement of the support device when in a resistive mode. The handle mechanism lowers the first transportation mechanism to engage the surface and disengage the resistance portion from the surface in a transportive mode to encourage movement of the support device and the item supported thereon.

Abstract: A coupler removably connectable to a decorating bag. The coupler includes an inner coupler configured to be inserted into the decorating bag, an outer coupler configured to removably secure to the inner coupler with the decorating bag disposed between the inner coupler and the outer coupler and a retainer configured to receive a decorating tip and removably secure to the outer coupler in order to lock the decorating tip into position.

Abstract: An imprinter for creating impressions of designs in media such as buttercream, fondant, gum paste, modeling dough, and cookie dough for decoration. The imprinter includes a retainer having a retainer body and at least one retaining portion and a lock configured to be received by the retainer. The lock has a lock retaining portion engageable with the retaining portion of the retainer to selectably secure the lock to the retainer.

Abstract: An imprinter for creating impressions of designs in media such as buttercream, fondant, gum paste, modeling dough, and cookie dough for decoration. The imprinter includes a retainer having a retainer body and at least one retaining portion and a lock configured to be received by the retainer. The lock has a lock retaining portion engageable with the retaining portion of the retainer to selectably secure the lock to the retainer.

Abstract: A support device for moving an item on a surface. A main body includes a panel and a sidewall. A handle assembly engages the main body and includes a first transportation mechanism. The support device includes a resistance portion on the main body for engaging a surface and resisting movement of the support device when in a resistive mode. The handle mechanism lowers the first transportation mechanism to engage the surface and disengage the resistance portion from the surface in a transportive mode to encourage movement of the support device and the item supported thereon.