Patents by Inventor Erkan Osman

Erkan Osman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMN2 element 1 antisense compositions and methods and uses thereof
    Patent number: 11136580
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: October 5, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Christian Lorson, Erkan Osman
  • SMN2 Element 1 Antisense Compositions and Methods and Uses Thereof
    Publication number: 20200157538
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Application
    Filed: November 11, 2019
    Publication date: May 21, 2020
    Inventors: Christian Lorson, Erkan Osman
  • SMN2 element 1 antisense compositions and methods and uses thereof
    Patent number: 10472630
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: November 12, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Christian Lorson, Erkan Osman
  • SMN2 Element 1 Antisense Compositions and Methods and Uses Thereof
    Publication number: 20180148724
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Application
    Filed: December 29, 2017
    Publication date: May 31, 2018
    Inventors: Christian Lorson, Erkan Osman
  • SMN2 element 1 antisense compositions and methods and uses thereof
    Patent number: 9885040
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: February 6, 2018
    Assignee: The Curators of The University Of Missouri
    Inventors: Christian Lorson, Erkan Osman
  • SMN2 Element 1 Antisense Compositions and Methods and Uses Thereof
    Publication number: 20160068838
    Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 10, 2016
    Inventors: Christian Lorson, Erkan Osman