Patents by Inventor Erkin Seker
Erkin Seker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11209383Abstract: A biosensor platform apparatus and method are provided that can detect, purify and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods use a two-stage molecular based approach. The first stage screens for specific nucleic acid-based biomarkers in complex biological fluids by electrochemical detection of DNA:RNA hybridization and facilitates the removal of remaining complex media constituents. The first stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be assisted with a library of conductance measurements. The methods can provide strain level information that can be used for identifying anti-microbial resistance in detected pathogens. Collection of RNA targets allows for biomarker detection and identification without the need for amplification and can provide information about the viability of the sample organism.Type: GrantFiled: October 31, 2018Date of Patent: December 28, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Erkin Seker, Joshua Hihath, Maria Marco, Paul Feldstein, Pallavi Daggumati, Yuanhui Li, Zimple Matharu, Juan Artes Vivancos
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Patent number: 10400270Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: GrantFiled: September 12, 2017Date of Patent: September 3, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk
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Publication number: 20190137434Abstract: A biosensor platform apparatus and method are provided that can detect, purify and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods use a two-stage molecular based approach. The first stage screens for specific nucleic acid-based biomarkers in complex biological fluids by electrochemical detection of DNA:RNA hybridization and facilitates the removal of remaining complex media constituents. The first stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be assisted with a library of conductance measurements. The methods can provide strain level information that can be used for identifying anti-microbial resistance in detected pathogens. Collection of RNA targets allows for biomarker detection and identification without the need for amplification and can provide information about the viability of the sample organism.Type: ApplicationFiled: October 31, 2018Publication date: May 9, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Erkin Seker, Joshua Hihath, Maria Marco, Paul Feldstein, Pallavi Daggumati, Yuanhui Li, Zimple Matharu, Juan Artes Vivancos
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Publication number: 20180066310Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: ApplicationFiled: September 12, 2017Publication date: March 8, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk
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Patent number: 9803234Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: GrantFiled: April 1, 2015Date of Patent: October 31, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk
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Patent number: 9387152Abstract: The invention relates to blood substitute compositions, and methods of use thereof. Described herein are compositions in which hemoglobin is maintained substantially in the reduced form of hemoglobin as opposed to the oxidized methemoglobin form through inclusion of an oxido-reductase enzyme and reducing agent within a vesicle with the hemoglobin. The vesicles additionally can comprise a dismutase, a catalase, and an electron acceptor, each of which contribute to either the maintenance of hemoglobin in the active oxygen carrying state or provide a benefit not achieved with free hemoglobin.Type: GrantFiled: June 28, 2011Date of Patent: July 12, 2016Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Martin L. Yarmush, Eric Yang, Tali Konry, Erkin Seker, Dhruv Sarin, Prakash Rai
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Publication number: 20150275279Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: ApplicationFiled: April 1, 2015Publication date: October 1, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk
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Patent number: 9070492Abstract: A method is disclosed for fabricating a low-impedance nanoporous metal multiple electrode array for measuring electrophysiology activity. A patterned photoresist is applied to a substrate, in which the patterned photoresist corresponds to a pattern of the nanoporous metal multiple electrode array. A metal alloy including a sacrificial alloying element is deposited in the pattern of the nanoporous metal electrode array. The patterned photoresist is removed to expose the metal alloy as deposited. At least part of the sacrificial alloying element is removed from the metal alloy to create nanoporous metal electrode tips thereby forming the nanoporous metal multiple electrode array. The resultant nanoporous metal multiple electrode array has improved impedance characteristics in comparison to conventional multiple electrode arrays.Type: GrantFiled: September 13, 2011Date of Patent: June 30, 2015Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Martin L. Yarmush, Erkin Seker, Yevgeny Berdichevsky
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Publication number: 20130307170Abstract: The invention relates to blood substitute compositions, and methods of use thereof. Described herein are compositions in which hemoglobin is maintained substantially in the reduced form of hemoglobin as opposed to the oxidized methemoglobin form through inclusion of an oxido-reductase enzyme and reducing agent within a vesicle with the hemoglobin. The vesicles additionally can comprise a dismutase, a catalase, and an electron acceptor, each of which contribute to either the maintenance of hemoglobin in the active oxygen carrying state or provide a benefit not achieved with free hemoglobin.Type: ApplicationFiled: June 28, 2011Publication date: November 21, 2013Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Martin L. Yarmush, Eric Yang, Tali Konry, Erkin Seker, Dhruv Sarin, Prakash Rai
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Publication number: 20130245416Abstract: A method is disclosed for fabricating a low-impedance nanoporous metal multiple electrode array for measuring electrophysiology activity. A patterned photoresist is applied to a substrate, in which the patterned photoresist corresponds to a pattern of the nanoporous metal multiple electrode array. A metal alloy including a sacrificial alloying element is deposited in the pattern of the nanoporous metal electrode array. The patterned photoresist is removed to expose the metal alloy as deposited. At least part of the sacrificial alloying element is removed from the metal alloy to create nanoporous metal electrode tips thereby forming the nanoporous metal multiple electrode array. The resultant nanoporous metal multiple electrode array has improved impedance characteristics in comparison to conventional multiple electrode arrays.Type: ApplicationFiled: September 13, 2011Publication date: September 19, 2013Inventors: Martin L. Yarmush, Erkin Seker, Yevgeny Berdichevsky