Patents by Inventor Erkki J. Honkanen
Erkki J. Honkanen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5512572Abstract: A method for preventing or treating myocardial ischemia in a mammalian organism is disclosed. The compound 4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl!hydrazono!prop anedinitrile or its enantiomer or a pharmaceutically acceptable salt there is administered to a mammalian organism in need of such prevention or treatment. The compound may be administered in its racemic form or in a form which is substantially free of the (+)-enantiomer or substantially free of the (-)-enantiomer.Type: GrantFiled: November 22, 1994Date of Patent: April 30, 1996Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Juoko M. Levijoki, Reijo J. Backstrom, Pentti T. Nore, Erkki J. Honkanen
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Patent number: 5446194Abstract: A compound according to formula 1 ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms or which is substituted with hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable esters and salts thereof, and a pharmaceutically acceptable carrier therefor, as well as pharmaceutical compositions containing said compounds as COMT inhibitors.Type: GrantFiled: September 16, 1993Date of Patent: August 29, 1995Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 5292771Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.Type: GrantFiled: October 8, 1992Date of Patent: March 8, 1994Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Erkki J. Honkanen, Jarmo J. Pystynen, Anne M. Luiro, Paivi A. Aho, Inge-Britt Y. Linden, Erkki A. O. Nissinen, Pentti Pohto
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Patent number: 5288750Type: GrantFiled: January 31, 1991Date of Patent: February 22, 1994Assignee: Orion-yhtyma OyInventors: Pentti Pohto, Paivi A. Aho, Reijo J. Backstrom, Erkki J. Honkanen, Inge-Britt Y. Linden, Erkki A. O. Nissinen
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Patent number: 5283352Abstract: Catechol compounds of formula I ##STR1## where R.sub.1, R.sub.2, R.sub.3 and X are as described herein are effective Catechol-O-methyltransferase inhibitors.Type: GrantFiled: December 7, 1992Date of Patent: February 1, 1994Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 5185370Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.Type: GrantFiled: January 31, 1991Date of Patent: February 9, 1993Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Erkki J. Honkanen, Jarmo J. Pystynen, Anne M. Luiro, Paivi A. Aho, Inge-Britt Y. Linden, Erkki A. O. Nissinen, Pentti Pohto
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Patent number: 5185332Abstract: New heterocyclic compounds of formula I ##STR1## In which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 --group; R.sub.1 and R.sub.2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrgen or lower alkyl or R.sub.1 and R.sub.2 together form a susbtituted or unsubstituted 5 or 6 membered ring which may contain 1 to 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 means independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.Type: GrantFiled: March 15, 1991Date of Patent: February 9, 1993Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Erkki J. Honkanen, Kari K. Lonnberg, Pentti T. Nore, Jarmo J. Pystynen, Anne M. Luiro, Aino K. Pippuri
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Patent number: 5151420Abstract: Substituted benzylideneiminophyenylpyridazinones or dihydropyridazinones of formula I ##STR1## in which R.sub.1 and R.sub.8 independently mean hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, trifluoromethyl, hydroxy alkyl, halogen alkyl, alkoxy alkyl, pyridyl, furyl, thienyl or cycloalkyl or one of optionally substituted groups; aryl, aralkyl, aralkenyl or nitrogen containing heterocyclic ring joining through an alkyl or alkenyl group and R.sub.3, R.sub.4 and R.sub.5 independently mean hydrogen, lower alkyl, hydroxy alkyl, halogen, hydroxy, alkoxy, acyloxy, aroyloxy, formyl, acyl, cyano, amino, carboxy or trifluoromethyl, R.sub.6 and R.sub.7 independently mean hydrogen, amino, lower alkyl, hydroxy, nitro or cyano or R.sub.2 and R.sub.7 together form a --CH.sub.2 --NH-- or --CH.dbd.N-- group and A means phenyl, naphtyl or a nitrogen containing heterocyclic ring. The compounds may be used in the treatment of congestive heart failure.Type: GrantFiled: March 8, 1990Date of Patent: September 29, 1992Assignee: Orion Corporation/Orion PharmaceuticaInventors: Reijo J. Backstrom, Kalevi E. Heinola, Pentti T. Nore, Jarmo J. Pystynen, Erkki J. Honkanen, Heimo O. Haikala
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Patent number: 5135950Abstract: Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).Type: GrantFiled: October 31, 1990Date of Patent: August 4, 1992Assignee: Orion-yhtyma OyInventors: Aino K. Pippuri, Erkki J. Honkanen, Jorma V. Haarala
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Patent number: 5122524Abstract: New heterocyclic compounds of formula I ##STR1## in which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 -- group; R.sub.1 and R.sub.2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrogen or lower alkyl or R.sub.1 and R.sub.2 together form a substituted or unsubstituted 5 or 6 membered ring which may contain 1 or 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 mean independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.Type: GrantFiled: March 15, 1991Date of Patent: June 16, 1992Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Erkki J. Honkanen, Kari K. Lonnberg, Pentti T. Nore, Jarmo J. Pystynen, Anne M. Luiro, Aino K. Pippuri
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Patent number: 5112861Abstract: The invention concerns a method for the treatment of Parkinson's Disease. The method comprises administering a catechol-O-methyl-transferase inhibiting amount of a compound having the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkylcarbamoyl of 2 to 5 carbon atoms or alkylcarbonyl of 2 to 5 carbon atoms, X represents nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano; alkylcarbonyl of 2 to 5 carbon atoms; or carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, or hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable salts or esters thereof; and a sufficient amount of levodopa to treat Parkinson's Disease. A peripheral decarboxylase inhibitor such as carbidopa or benzerazide is also preferably administered.Type: GrantFiled: September 25, 1990Date of Patent: May 12, 1992Assignee: Orion-yhtyma OyInventors: Reijo Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo Pystynen
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Patent number: 5019575Abstract: New heterocyclic compounds of formula I ##STR1## in which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 --group; R.sub.1 and R.sub.2 independently means nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrogen or lower alkyl or R.sub.1 and R.sub.2 together form a substituted or unsubstituted 5 or 6 membered ring which may contain 1 or 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 mean independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.Type: GrantFiled: February 9, 1990Date of Patent: May 28, 1991Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Erkki J. Honkanen, Kari K. Lonnberg, Pentti T. Nore, Jarmo J. Pystynen, Anne M. Luiro, Aino K. Pippuri
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Patent number: 5001152Abstract: The invention is concerned with the new use of known catechol derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms; X is nitro, halogen or cyano and R.sub.3 is chlorine, nitro, cyano or a radical of the formula ##STR2## wherein R.sub.4 is hydrogen, cyano, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms and R.sub.5 is cyano, alkanoyl having 2 to 5 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, carboxyl or phenylcarbonyl unsubstituted or substituted with one to three methoxy groups or pharmaceutically acceptable salt thereof. The new use is the treatment and prophylaxis of ulcers and lesions in the gastrointestinal tract.Type: GrantFiled: December 23, 1988Date of Patent: March 19, 1991Assignee: Orion Corporation Ltd.Inventors: Paivi A. Aho, Pentti Pohto, Inge-Britt Y. Linden, Reijo J. Backstrom, Erkki J. Honkanen, Erkki A. O. Nissenen
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Patent number: 4963590Abstract: Pharmacologically active catechol derivatives of formula I ##STR1## wherein R.sub.1 and R.sub.2 independently comprise hydrogen, alkyl, acyl, optionally substituted aroyl, lower alkylsulfonyl or alkylcabamoyl or taken together form a lower alkylidene or cycloalkylidene, X comprises an electronegative substituent such as halogen, nitro, cyano, lower alkylsulfonyl, sulfonamido, aldehyde, caboxyl or trifluoromethyl and R.sub.3 comprises hydrogen, halogen, hydroxy alkyl, amino, nitro, cyano, trifluoromethyl, lower alkylsulfonyl, sulfonamide, aldehyde, alkyl carbonyl, aralkylidene carbonyl or carboxyl or a group selected from ##STR2## wherein R.sub.4 comprises hydrogen, alkyl, cyano, carboxyl or acyl and R.sub.5 comprises hydrogen, cyano, carboxyl, alkoxycarbonyl, carboxyalkenyl, nitro, acyl, optionally substituted aroyl or heteroaroyl, hydroxyalkyl or carboxyalkyl or R.sub.4 and R.sub.5 together form a five to seven membered substituted cycloalkanone ring;--(CO).sub.n (CH.sub.2).sub.Type: GrantFiled: November 27, 1987Date of Patent: October 16, 1990Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka T. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 4963677Abstract: A compound of the formula ##STR1## and pharmaceutically acceptable salts thereof, in which A is --N.dbd.N--NH--, --X--C(R.sub.2).dbd.N--, --N.dbd.C(R.sub.2)--X--, --X--C(R.sub.2)--CH(R.sub.2).dbd.N-- or --N.dbd.C(R.sub.2)--CH(R.sub.2)--X--, wherein X is sulphur, oxygen or nitrogen and R.sub.2 is provided that where two R.sub.2 -groups are present in the A group one of the R.sub.2 groups is hydrogen, amino, substituted amino, C.sub.1-6 alkyl, substituted acylamino or one of the following groups: ##STR2## wherein R.sub.a is hydrogen, amino, substituted amino, C.sub.1-6 alkoxy, heterocyclic five membered ring or --NHCOR', wherein R' is C.sub.1-6 alkyl, aryl or heterocyclic five membered ring, R.sub.b is hydrogen, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio or hydroxy, R.sub.c is hydrogen, C.sub.1-6 alkyl or oxygen and R.sub.d is C.sub.1-6 alkyl or oxygen, R.sub.e is hydrogen, hydroxy or C.sub.1-6 alkoxy, R.sub.f is C.sub.1-6 alkyl, provided that where two R.sub.2 -groups are present in the A group, one of the R.sub.Type: GrantFiled: November 8, 1988Date of Patent: October 16, 1990Assignee: Orion Corporation Ltd.Inventors: Lawrence Sellin, Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Tord K. W. Langenskiold, Irma O. Ojala, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 4599326Abstract: The invention relates to a new antibiotic compound, acetyl erythromycin stearate having formula I ##STR1## The compound according to the invention is absorbed readily from the alimentary tract. Gastric acid does not convert the compound according to the invention to an uneffective form as is the case with some other erythromycin antibiotics. Absorbing is good also when the patient eats when taking the new medicine.The compound according to the invention is prepared by reacting erythromycin base with acetyl halide in an organic solvent in the presence of an acid acceptor. The stearate salt is prepared from the obtained ester without in between isolating the ester.Type: GrantFiled: December 27, 1984Date of Patent: July 8, 1986Assignee: Orion-yhtyma OyInventors: Martti L. A. Marvola, Esko V. Marttila, Jaakko A. Uotila, Aino K. Pippuri, Pekka J. Kairisalo, Erkki J. Honkanen
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Patent number: 4353914Abstract: The invention relates to novel antitussive anilides and non-toxic acid addition salts thereof. These novel compounds have the general formula ##STR1## wherein n is an integer from 2 to 3, and substituents R.sup.1 and R.sup.2 are lower alkyl groups or form together with the nitrogen atom to which they are attached a piperidine ring which is substituted by a methyl group. The invention also relates to a process for preparing these novel compounds.Type: GrantFiled: January 11, 1980Date of Patent: October 12, 1982Assignee: Orion-yhtyma OyInventors: Juhani O. W. Kaila, Erkki J. Honkanen, Joachim E. Alberty, Jaakko J. Hukki
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Patent number: 4299846Abstract: New 1,8-dihydroxy-10-acyl-9-anthrones having anti-psoriatic activity are disclosed.Type: GrantFiled: March 25, 1980Date of Patent: November 10, 1981Assignee: Orion-yhtyma OyInventors: Kimmo K. Mustakallio, Aino K. Pippuri, Erkki J. Honkanen
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Patent number: 4271300Abstract: An improved method is disclosed for producing antihypertensively active 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl] quinazoline hydrochloride, viz prazosine hydrochloride, by reacting methyl-N-(3,4-dimethoxy-6-cyano-phenyl)-[4-(2-furoyl)-1-piperazinyl]thiofo rmamidate with a large excess of ammonium chloride.Type: GrantFiled: January 9, 1980Date of Patent: June 2, 1981Assignee: Orion-yhtyma OyInventors: Erkki J. Honkanen, Aino K. Pippuri, Pekka J. Kairisalo, Heinrich Thaler, Maija K. Koivisto, Sirpa A. Tuomi