Patents by Inventor Erling C. J. Norrby

Erling C. J. Norrby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and diagnostic kits for the detections of HIV-2-specific antibodies employing polypeptides obtained from the simian immunodeficiency virus
    Patent number: 5670309
    Abstract: The simian immunodeficiency virus (SIV) is genotypically and phenotypically similar to the human immunodeficiency virus type 2 (HIV-2). Both viruses display similar structural, biological, and immunological properties. The external envelope glycoprotein (EMP) and transmembrane envelope glycoprotein (TMP) appear to be formed from the cleavage of a precursor glycoprotein. Despite these similarities, a number of differences exist as evidenced by the different migratory properties of the envelope glycoproteins. The present invention discloses novel SIV peptides, obtained from the transmembrane envelope glycoprotein, that display immunological cross-reactivity with HIV-2-specific antisera. Epitope mapping studies revealed that the amino acid sequence --CAFRQVC--, which corresponds to amino acid residues 614-620, is a sine qua non for the retention of this immunological cross-reactivity. These peptides are useful in diagnostic methods for the detection of HIV-2-specific antibodies in infected patients.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: September 23, 1997
    Assignee: Johnson & Johnson
    Inventors: Erling C. J. Norrby, D. Elliot Parks, Richard A. Lerner