Patents by Inventor Erling Guddal
Erling Guddal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050222098Abstract: Compounds of Formula I and methods of regulating the meiosis in a mammalian germ cell which method comprises administering an effective amount of the compound of Formula I to a germ cell in need of such a treatment.Type: ApplicationFiled: May 18, 2005Publication date: October 6, 2005Applicant: Novo Nordisk A/SInventors: Anne Byskov, Claus Andersen, Lars Nordholm, Henning Thogersen, Ole Wassman, Ivan Diers, Erling Guddal
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Publication number: 20040048838Abstract: Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.Type: ApplicationFiled: September 9, 2003Publication date: March 11, 2004Inventors: Frederik Christian Gronvald, Peter Faarup, Erling Guddal
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Patent number: 6645953Abstract: Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.Type: GrantFiled: June 11, 2001Date of Patent: November 11, 2003Assignee: Novo Nordisk A/SInventors: Frederik Christian Gronvald, Peter Faarup, Erling Guddal
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Publication number: 20020013302Abstract: Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.Type: ApplicationFiled: June 11, 2001Publication date: January 31, 2002Inventors: Frederick Christian Gronvald, Peter Faarup, Erling Guddal
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Patent number: 5830757Abstract: The present invention relates to the use of certain chemical compounds which interfere with the biosynthesis of cholesterol and medicaments comprising such compounds for stimulating the meiosis of oocytes and spermatozoon in vivo, ex vivo and in vitro.Type: GrantFiled: February 28, 1997Date of Patent: November 3, 1998Assignee: Novo Nordisk A/SInventors: Erling Guddal, Anne Grete Byskov, Frederik Christian Gr.o slashed.nvald, Lars Nordholm
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Patent number: 5716777Abstract: The present invention relates to certain sterol derivatives for use as medicaments.Type: GrantFiled: May 23, 1995Date of Patent: February 10, 1998Assignee: Novo Nordisk A/SInventors: Anne Grete Byskov, Claus Yding Andersen, Lars Nordholm, Henning Th.o slashed.gersen, Ole Wassmann, Ivan Verner Diers, Erling Guddal
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Patent number: 5284847Abstract: Novel thieno[2,3-b]pyrazine-2,3(1H,3H)-diones or tautomeric forms thereof of the formula (I) ##STR1## The compounds are useful in the treatment of neurological and psychiatric diseases.Type: GrantFiled: October 16, 1992Date of Patent: February 8, 1994Assignee: Novo Nordisk A/SInventors: Anker S. Jorgensen, Peter Faarup, Erling Guddal, Lone Jeppesen
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Patent number: 5276035Abstract: A disubstituted piperazine compound having the formula ##STR1## wherein R.sup.1 is halogen, methoxy, C.sub.1-6 -alkyl or trifluoromethyl, and R.sup.2 is methyl or substituted C.sub.1-8 -alkyl, C.sub.3-8 -alkenyl or C.sub.3-8 -cycloalkyl, where substituents may be hydroxy-, keto- or oximino-groups in any position leading to a stable tertiary amine; or R.sup.2 is a straight or branched C.sub.1-8 -alkyl or C.sub.3-8 -alkenyl, which in any position may be substituted as above, but is terminally substituted with one of the following groups: cyano, optionally C.sub.1-4 -alkoxy-substituted C.sub.1-4 -alkoxy, dimethoxy, optiontionally substituted phenoxy, phosphonic acid, thienyl, furyl, oxazoline, isoxazole, oxadiazole, where the optional substitution is represented by C.sub.1-6 -alkyl or phenyl, provided that when cyano is the only substituent in R.sup.2, R.sup.2 must contain at least four carbon atoms, and pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: May 4, 1992Date of Patent: January 4, 1994Assignee: Novo Nordisk A/SInventors: Rolf Hohlweg, Erling Guddal, Erik B. Nielsen
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Patent number: 5177077Abstract: A disubstituted piperazine compound having the formula I ##STR1## wherein R.sup.1 is thienyl or phenyl, which may be substituted with C.sub.1-6 -alkyl or halogen, and R.sup.2 is thienyl, which may be substituted with C.sub.1-6 -alkyl or halogen, and R.sup.3 is C.sub.1-8 -alkyl, C.sub.3-8 -alkenyl or C.sub.3-8 -cycloalkyl which all may be substituted with hydroxy, oximino or keto in any position giving a stable tertiary amine or R.sup.3 is C.sub.1-8 -alkyl or C.sub.3-8 -alkenyl which in any position may be substituted as above, but is terminally substituted with phenoxy, phenyl, thienyl, furyl, methoxy or --CN and pharmaceutically acceptable acid addition salts thereof.The compounds are useful in the treatment of mental disorders in which a dopaminergic deficit is implicated.Type: GrantFiled: July 11, 1991Date of Patent: January 5, 1993Assignee: Novo Nordisk A/SInventors: Rolf Hohlweg, Erling Guddal, Erik Nielsen
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Patent number: 5025009Abstract: Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl;R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represents hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among--O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O--CH.dbd.CH--, --CH.sub.2, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.Type: GrantFiled: February 7, 1990Date of Patent: June 18, 1991Assignee: Novo Nordisk A/SInventors: Frederik Gronwald, Peter H. Andersen, Peter Faarup, Erling Guddal, Kristian T. Hansen, Louis B. Hansen, Erik B. Nielsen
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Patent number: 5010074Abstract: Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl; R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represent hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or alkoxy or trifluoromethyl, or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among --O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-CH.dbd.CH--, --CH.sub.2 -CH.sub.2 -CH.sub.2 --, --CH.sub.2 -CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R.sup.Type: GrantFiled: June 12, 1989Date of Patent: April 23, 1991Assignee: Novo Nordisk A/SInventors: Frederik Gronwald, Peter H. Andersen, Peter Faarup, Erling Guddal, Kristian T. Hansen, Louis B. Hansen, Erik B. Nielsen
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Patent number: 4202817Abstract: A process for the preparation of penam and cephem derivatives by reacting a phosphite amide of a 6-aminopenicillanic acid or 7-aminocephalosporanic acid with an acyl halide in an aprotic solvent in the presence of a phosphite halide scavenger.Type: GrantFiled: September 18, 1978Date of Patent: May 13, 1980Assignee: Novo Industri A/SInventors: Erling Guddal, Poul Borrevang
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Patent number: 4178294Abstract: p-Trimethylsilyloxy-D-(-)-phenylglycyloxysuccinimide or -phthalimide, process of preparing p-trimethylsilyloxy-D-(-)-phenylglycyloxysuccinimide or -phthalimide by reacting D-(-)-p-trimethylsilyloxyphenylglycin-N-carboxyanhydride with a N-hydroxyimide, and process for preparing 6-(p-hydroxyphenylglycylamido)-penam or 7-(p-hydroxyphenylglycylamido)-cephem compounds by reacting p-trimethylsilyloxy-D-(-)-phenylglycyloxysuccinimide or -phthalimide with a phosphite amide or an ester of 6-aminopenicillanic acid or of an ester of a 7-amino-3-cephem-4-carboxylic acid in the presence of the hydrochloride of a weak amine.Type: GrantFiled: November 2, 1977Date of Patent: December 11, 1979Assignee: Novo Industri A/SInventor: Erling Guddal
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Patent number: 4098796Abstract: P-Trimethylsilyloxy-D-(-)-phenylglycyloxysuccinimide or -phthalimide, process of preparing p-trimethylsilyloxy-D-(-)-phenylglycyloxysuccinimide or -phthalimide by reacting D-(-)-p-trimethylsilyloxyphenylglycin-N-carboxyanhydride with a N-hydroxyimide, and process for preparing 6-(p-hydroxyphenylglycylamido)-penam or 7-(p-hydroxyphenylglycylamido)-cephem compounds by reacting p-trimethylsilyloxy-D-(-)-phenylglycyloxysuccinimide or -phthalimide with a phosphite amide of an ester of 6-aminopenicillanic acid or of an ester of a 7-amino-3-cephem-4-carboxylic acid in the presence of the hydrochloride of a weak amine.Type: GrantFiled: June 7, 1976Date of Patent: July 4, 1978Assignee: Novvo Industri A/SInventor: Erling Guddal
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Patent number: 4082745Abstract: An improvement in the conversion of penam and cephem compounds to secondary ammonium salts of phosphite amides thereof by reacting as follows: ##STR1## wherein --R, is the non-reacting balance of the penam or cephem compound and ##STR2## ARE NON-REACTING SUBSTITUENTS. Catalytic amounts of H--N< or the hydrogenhalide thereof may be present in the reaction medium.Type: GrantFiled: March 22, 1976Date of Patent: April 4, 1978Assignee: Novo Industri A/SInventors: Poul Borrevang, Erling Guddal, Henning Borge Petersen, Peter Faarup, Jorgen Ilum Nielsen
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Patent number: 3994883Abstract: Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.Type: GrantFiled: December 21, 1973Date of Patent: November 30, 1976Assignee: Novo Industri A/SInventors: Poul Borrevang, Erling Guddal, Henning Borge Petersen, Peter Faarup, Jorgen Ilum Nielsen