Patents by Inventor Erminio Costa

Erminio Costa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of simultaneously treating sensory auditory gating deficit and associated psychosis in schizophrenia and bipolar disorder patients with mania
    Patent number: 6964958
    Abstract: Schizophrenia and bipolar disorders with mania may be treated by imidazenil or other benzodiazepine-3-carboxamide derviatives.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: November 15, 2005
    Inventors: James Auta, Erminio Costa, John M. Davis, Alessandro Guidotti, Patricia Tueting
  • Method of simultaneously treating sensory auditory gating deficit and associated psychosis in schizophrenia and bipolar disorder patients with mania
    Publication number: 20030119821
    Abstract: Schizophrenia and bipolar disorders with mania may be treated by imidazenil or other benzodiazepine-3-carboxamide derviatives.
    Type: Application
    Filed: September 20, 2002
    Publication date: June 26, 2003
    Inventors: James Auta, Erminio Costa, John M. Davis, Alessandro Guidotti, Patricia Tueting
  • Method of treating learning and memory disorders using benzothiadiazide derivatives as nootropic agents
    Patent number: 5488049
    Abstract: The present invention is directed to the use of benzothiadiazide derivatives as nootropic agents to treat memory and learning disorders.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: January 30, 1996
    Assignee: FIDIA - Georgetown Institute for the Neuro-Sciences
    Inventors: Erminio Costa, Alessandro Guidotti, Mario Baraldi, Mariella Bertolino, Maria DiBella, Stefano Vicini
  • Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy
    Patent number: 5317018
    Abstract: The present invention is directed to imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide compounds of the formula: ##STR1## wherein R is hydrogen, C.sub.3 CH.sub.2 --, CH.sub.2 .dbd.CHCH.sub.2 --, (CH.sub.3).sub.2 CH--, CH.sub.3 CH.sub.2 CH.sub.2 --, or ##STR2## or a pharmaceutically acceptable salt thereof. These compounds and their pharmaceutically acceptable salts possess anti-anxiety and anti-epileptic activity.
    Type: Grant
    Filed: June 9, 1992
    Date of Patent: May 31, 1994
    Inventors: Armin Walser, Alessandro Guidotti, Erminio Costa
  • Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders
    Patent number: 5206382
    Abstract: A compound having the formula: ##STR1## wherein R.sub.1 and R.sub.2 independently is selected from the group consisting of H, C.sub.3 -C.sub.12 straight or branched alkyl, aryl or lower alkyl-substituted aryl; or R.sub.1 and R.sub.2 may be joined to form a 4-to 6-membered saturated or unsaturated ring or a 4-to 6-membered saturated or unsaturated lower alkyl-substituted ring; R.sub.3 is H, C.sub.1 -C.sub.12 straight or branched alkyl, NO.sub.2, NH.sub.2, N.sub.3, CN, halogen, CO.sub.2 R, OR, or SR wherein R is H or lower alkyl; R.sub.4 is H, C.sub.1 -C.sub.12 straight or branched alkyl, NO.sub.2, NH.sub.2, N.sub.3, CN, halogen, CO.sub.2 R, OR, or SR wherein R is H or lower alkyl; A is nothing or a C.sub.1 -C.sub.5 alkylene to form a ring; Z is 0, NH, S or --CH.dbd.CH--; and n is an integer of 1-3; or a pharmaceutically acceptable salt thereof. The compounds are useful in compositions and methods for treating psychiatric and neurological disorders.
    Type: Grant
    Filed: June 27, 1991
    Date of Patent: April 27, 1993
    Assignee: Fidia Georgetown Institute for the Neurosciences
    Inventors: Erminio Costa, Alessandro Guidotti, Alan Kozikowski, Dawei Ma
  • Azetidine derivatives to treat memory and learning disorders
    Patent number: 4990504
    Abstract: This invention relates to novel azetidines and derivatives thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: February 5, 1991
    Assignee: FIDIA-Georgetown Institute for the Neurosciences
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Erminio Costa
  • Azetidine derivatives, compositions and methods of treating
    Patent number: 4946839
    Abstract: This invention relates to novel azetidines and derivative thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: August 7, 1990
    Assignee: Fidia-Georgetown Institute for the Neurosciences
    Inventors: Alan P. Kozikowskip, Jarda T. Wroblewski, Erminio Costa
  • D-DOPA, pharmaceutically acceptable salts thereof, and methods of treating Parkinson's disease
    Patent number: 4863962
    Abstract: The present invention is directed to a method of treating Parkinson's disease. More particularly, the present invention utilizes D-DOPA or the racemic mixture of D,L-DOPA, or pharmaceutically acceptable salts thereof, in an anti-parkinsonism effective amount for the treatment of Parkinson's disease.
    Type: Grant
    Filed: March 2, 1988
    Date of Patent: September 5, 1989
    Assignee: Fidia-Georgetown Institute for the Neurosciences
    Inventors: Farouk Karoum, Erminio Costa