Abstract: Methods and device for marking animals are disclosed. An ear tag configurable for attachment to a rodent ear, e.g., a mouse ear, is presented, wherein the ear tag includes a color-coded image, an alphanumeric character string, a bar code and/or a visual signage. The tag may include the visual identifier and an RFID device. A card may be provided that redundantly displays some or all of the visual identifier. An applicator is alternately or additionally provided that removes separated elements of the tag from a tray force generated by manual compression of a pair of handles of the applicator, and additionally includes jaws that compress towards each other when the handles are initially compressed, yet splay and release the tag elements as additional compressive force is applied to the handles.

Abstract: Methods and device for marking animals are disclosed. An ear tag configurable for attachment to a rodent ear, e.g., a mouse ear, is presented, wherein the ear tag includes a color-coded image, an alphanumeric character string, a bar code and/or a visual signage. The tag may include the visual identifier and an RFID device. A card may be provided that redundantly displays some or all of the visual identifier. An applicator is alternately or additionally provided that removes separated elements of the tag from a tray force generated by manual compression of a pair of handles of the applicator, and additionally includes jaws that compress towards each other when the handles are initially compressed, yet splay and release the tag elements as additional compressive force is applied to the handles.

Abstract: Methods and device for marking animals are disclosed. An ear tag configurable for attachment to a rodent ear, e.g., a mouse ear, is presented, wherein the ear tag includes a color-coded image, an alphanumeric character string, a bar code and/or a visual signage. The tag may include the visual identifier and an RFID device. A card may be provided that redundantly displays some or all of the visual identifier. An applicator is alternately or additionally provided that removes separated elements of the tag from a tray force generated by manual compression of a pair of handles of the applicator, and additionally includes jaws that compress towards each other when the handles are initially compressed, yet splay and release the tag elements as additional compressive force is applied to the handles.

Abstract: The invention provides devices for analyzing genetic material comprising a substrate and a first genetic material position and a second genetic material position on the substrate that each comprise genetic material attached to the substrate. The invention also provides methods of distributing genetic material comprising distributing at least one device.

Abstract: The present invention provides a novel gene delivery system in which a gene delivery facilitating peptide, generally derived from Histone H2A, is complexed with a nucleic acid for efficient and stable delivery of the nucleic acid into a cell, ultimately to the nucleus. Such peptide-mediated gene delivery is based on the principal that unneutralized positive charges on the histone are bound electrostatically both by the negatively charged phosphate backbone of DNA and that nuclear targeting signals in histones improve trafficking of the DNA to the nucleus for transcription.

Abstract: Treatment of patients having multiple sclerosis with therapeutic agents containing substituted adenine derivatives such as 2-chloro-2'-deoxyadenosine is shown to markedly ameliorate the disease condition.

Abstract: A process for the treatment of chronic myelogenous leukemia in mammals is disclosed that utilizes a 2-halo-2'-deoxyadenosine derivative as the active treating agent.

Abstract: A method for detecting a new Gaucher disease mutation in an allele in a human having a point mutation of an adenine nucleotide substituted for a guanine nucleotide at nucleotide position 1 in the normal glucocerebrosidase gene intron 2 is provided. Identification of the mutation is accomplished by first amplifying, with a polymerase chain reaction (PCR) primer, a region of human genomic DNA containing nucleotide position 1 of glucocerebrosidase gene intron 2 followed by detection of the mutation.

Abstract: A method for detecting a new Gaucher disease mutation in an allele in a human having an insertion mutation of a guanine nucleotide adjacent to nucleotide position 57 in the normal glucocerebrosidase gene exon 2 is provided. Identification of the mutation is accomplished by first amplifying, with a polymerase chain reaction (PCR) primer, a region of human genomic DNA containing nucleotide positions 57 and 58 of glucocerebrosidase gene exon 2 followed by detection of the mutation.