Patents by Inventor Ernest E. Muirhead

Ernest E. Muirhead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antihypertensive compounds
    Patent number: 4742051
    Abstract: Compounds are described having the formula ##STR1## wherein R.sup.1 is an alkyl or alkenyl group having from about 11 to about 23 carbon atoms;R.sup.2 is hydrogen or an alkyl or alkenyl group having from about 1 to about 11 carbon atoms;R.sup.3 is NR.sub.4 R.sub.5 or NR.sub.4 R.sub.5 R.sub.6.sup.+ An.sup.-wherein R.sub.4, R.sub.5 and R.sub.6 are independently hydrogen or lower alkyl having from 1 to 3 carbon atoms and An is an anion; andY represents the hydrogens of a methylene group or the oxygen of a carbonyl group.These compounds are useful as vasodilators and antihypertensive agents.
    Type: Grant
    Filed: July 17, 1981
    Date of Patent: May 3, 1988
    Assignee: University of Tennessee Research Corporation
    Inventors: Ernest E. Muirhead, Byron E. Leach, deceased, Lawrence W. Byers
  • Alkyl phospholipid antihypertensive agents in method of lowering blood pressure
    Patent number: 4725588
    Abstract: The composition of this invention is 1-O-alkyl-2-acetoyl-sn-glycero-3-phosphocholine, having the ionic structural formula; ##STR1## wherein R is saturated alkyl having 9-21 carbon atoms, or salts or hydrates of the composition. Preferably R has 13-19 carbon atoms and most preferably R has 15 carbon atoms. The composition of this invention is useful for reducing hypertension in warm-blooded animals, including humans, when administered either orally or by injection or innoculation, e.g., intravenous injection. The composition can be prepared from naturally occurring lipids or synthetically from commercially available material.
    Type: Grant
    Filed: February 9, 1981
    Date of Patent: February 16, 1988
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Fred L. Snyder, Merle L. Blank, Ernest E. Muirhead, Byron E. Leach, deceased, Lawrence W. Byers
  • Method for preparing a compound called ARL per se and its use as medicinal
    Patent number: 4206201
    Abstract: Compound (hereinafter identified as ARL) useful as a vasodilator and antihypertensive agent. The compound is obtainable using rabbit kidney medulla by first incubating same, second, operating on the incubated material and then purifying the operated upon material to remove cholesterol, triglycerides, and etc. to leave an ARL compound.
    Type: Grant
    Filed: August 7, 1978
    Date of Patent: June 3, 1980
    Inventors: Ernest E. Muirhead, Byron E. Leach, Lawrence W. Byers