Patents by Inventor Ernest J. Kiser
Ernest J. Kiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7361307Abstract: A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.Type: GrantFiled: July 7, 2004Date of Patent: April 22, 2008Assignee: LifeScan, Inc.Inventors: Robert Shartle, Koon-wah Leong, Ernest J. Kiser
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Patent number: 7144495Abstract: Methods and devices for electrochemically detecting a change in the viscosity of a fluid are provided. In the subject methods, a fluid sample (e.g., a whole blood sample) is introduced into an electrochemical test strip's electrochemical cell using a micro-needle integrated into one of oppositely spaced apart working and reference electrodes. An electric potential is applied to the electrochemical cell to first achieve a steady state cell current. A decrease in the steady state cell current is then detected and related to a change in viscosity of the sample. In many embodiments, the sample is blood and the change in viscosity is related to the onset of coagulation in the blood sample, and often the PT of the blood sample. An electrochemical test strip includes an electrochemical cell and an integrated micro-needle. The electrochemical cell includes oppositely spaced apart working and reference electrodes and a reagent mixture (e.g., a redox couple and a coagulation catalyzing agent).Type: GrantFiled: August 23, 2002Date of Patent: December 5, 2006Assignee: Lifescan, Inc.Inventors: Maria Teodorczyk, Ernest J. Kiser, Lorin P. Olson, Devin McAllister, Vadim V. Yuzhakov, Koon-wah Leong
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Patent number: 6949221Abstract: A test strip for determining the concentration of an analyte in a body fluid includes a membrane in fluid communication with a porous layer. The membrane and the porous layer are divided into compressed portions, which restrict the capillary flow of the body fluid, and uncompressed portions. The uncompressed portions are adapted to absorb and retain body fluids in excess of the amount required for operation of the test strip. The test strip may be constructed with an internal relief chamber to accommodate the uncompressed portions. A method of making the test strip by pressure and/or heat sealing individual components on a shaping die is also provided.Type: GrantFiled: March 28, 2002Date of Patent: September 27, 2005Assignee: LifeScan, Inc.Inventors: Ernest J. Kiser, Deborah P. Tuohy, John M. Dubowik
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Patent number: 6875613Abstract: A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.Type: GrantFiled: June 12, 2001Date of Patent: April 5, 2005Assignee: LifeScan, Inc.Inventors: Robert Shartle, Koon-wah Leong, Ernest J. Kiser
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Publication number: 20040249310Abstract: A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.Type: ApplicationFiled: July 7, 2004Publication date: December 9, 2004Inventors: Robert Shartle, Koon-wah Leong, Ernest J. Kiser
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Publication number: 20030150745Abstract: Methods and devices for electrochemically detecting a change in the viscosity of a fluid are provided. In the subject methods, a fluid sample (e.g., a whole blood sample) is introduced into an electrochemical test strip's electrochemical cell using a micro-needle integrated into one of oppositely spaced apart working and reference electrodes. An electric potential is applied to the electrochemical cell to first achieve a steady state cell current. A decrease in the steady state cell current is then detected and related to a change in viscosity of the sample. In many embodiments, the sample is blood and the change in viscosity is related to the onset of coagulation in the blood sample, and often the PT of the blood sample. An electrochemical test strip includes an electrochemical cell and an integrated micro-needle. The electrochemical cell includes oppositely spaced apart working and reference electrodes and a reagent mixture (e.g., a redox couple and a coagulation catalyzing agent).Type: ApplicationFiled: August 23, 2002Publication date: August 14, 2003Inventors: Maria Teodorczyk, Ernest J. Kiser, Lorin P. Olson, Devin McAllister, Vadim V. Yuzhakov, Koon-wah Leong
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Patent number: 6395227Abstract: A test strip for determining the concentration of an analyte in a body fluid includes a membrane in fluid communication with a porous layer. The membrane and the porous layer are divided into compressed portions, which restrict the capillary flow of the body fluid, and uncompressed portions. The uncompressed portions are adapted to absorb and retain body fluids in excess of the amount required for operation of the test strip. The test strip may be constructed with an internal relief chamber to accommodate the uncompressed portions. A method of making the test strip by pressure and/or heat sealing individual components on a shaping die is also provided.Type: GrantFiled: May 16, 1995Date of Patent: May 28, 2002Assignee: Lifescan, Inc.Inventors: Ernest J. Kiser, Deborah P. Tuohy, John M. Dubowik
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Patent number: 5719034Abstract: A chemical timer for a direct-reading reagent test strip changes color a predetermined time after a biological fluid is applied to the strip. The strip measures the concentration of an analyte in the fluid. The timer is a dry coating of an indicator, an enzyme-containing reagent that when hydrated can react with glucose to change the color of the indicator, an inhibitor to inhibit the change in color of the indicator, glucose, and optionally, an aldose that does not react with the enzyme in the reagent. Preferably, the reagent and glucose are present in excess in the coating, and the time it takes for the timer color to change can be controlled by the inhibitor concentration. The aldose provides timer stability, probably by interfering with glycosylation by the glucose in the dry state.Type: GrantFiled: September 3, 1996Date of Patent: February 17, 1998Assignee: Lifescan, Inc.Inventors: Ernest J. Kiser, Michael F. Tomasco, Edward G. Rice, Yeung S. Yu
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Patent number: 5418142Abstract: A separation matrix impregnated with a separating agent separates red blood cells or hemoglobin from whole blood. Upon separation, an impregnated test reagent reacts with the separated substantially clear component fluid to form a colored product which enables a visual or meter test for glucose levels in whole blood.Type: GrantFiled: October 13, 1992Date of Patent: May 23, 1995Assignee: Lifescan, Inc.Inventors: Ernest J. Kiser, Edward G. Rice, Michael F. Tomasco
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Patent number: 5306623Abstract: A separation matrix impregnated with a separating agent separates red blood cells or hemoglobin from whole blood. Upon separation, an impregnated test reagent reacts with the separated substantially clear component fluid to form a colored product which enables a visual or meter test for analyte levels in whole blood. Such a test is appropriate for, among other things measuring glucose, cholesterol, or alcohol levels in whole blood samples. A visual meter is disclosed which allows sample to be applied to one side of the strip, and reading takes place on the opposite side, after separation of red blood cells and reaction to test reagent. Also, a useful test strip format is disclosed.Type: GrantFiled: July 26, 1991Date of Patent: April 26, 1994Assignee: Lifescan, Inc.Inventors: Ernest J. Kiser, Edward G. Rice, Michael F. Tomasco
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Patent number: 4250029Abstract: Novel membranes having two or more coatings of polyelectrolytes with at least one oppositely charged adjacent pair of coatings separated by a neutral layer to reduce charge neutralization, their method of preparation, and use for rejecting ionically charged solutes.Type: GrantFiled: April 25, 1977Date of Patent: February 10, 1981Assignee: Rohm and Haas CompanyInventors: Ernest J. Kiser, James A. Latty
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Patent number: D381591Type: GrantFiled: May 31, 1996Date of Patent: July 29, 1997Assignee: LifeScan, Inc.Inventors: Edward G. Rice, Ernest J. Kiser, Karen R. Drexler, Jennifer Hahamian, Joel S. Douglas, Victoria Page