Patents by Inventor Ernest J. Mayer

Ernest J. Mayer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified tissue plasminogen activator with modified glycosylation site
    Patent number: 5244676
    Abstract: A modified t-PA having improved in vivo half-life is disclosed comprising in sequence a fibronectin finger-like domain F, a growth factor domain GF, a sequence of two K2 kringle regions and a serine protease region SP, wherein the first of said kringles is free of any glycosylation site and the second of said kringles has a single glycosylation site.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: September 14, 1993
    Assignee: Monsanto Company
    Inventors: Leslie D. Bell, Ernest J. Mayer, Mark O. Palmier, H. Eser Tolunay, Thomas G. Warren, Tze-Chein Wun
  • Modified tissue plasminogen activator K2K2SP
    Patent number: 5100666
    Abstract: A modified t-PA having improved in vivo half-life is disclosed comprising in sequence a sequence of two K2 kringle regions and a serine protease region SP.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: March 31, 1992
    Assignee: Monsanto Company
    Inventors: Leslie D. Bell, Ernest J. Mayer, Mark O. Palmier, H. Eser Tolunay, Thomas G. Warren, Tze-Chein Wun
  • Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
    Patent number: 5037752
    Abstract: A modified tissue plasminogen activator having an improved in vivo half-life characterized in that the normal protein moiety of 527 amino acids is mutated at the site Cys73.fwdarw.Arg and at the site Lys277.fwdarw.Asp.
    Type: Grant
    Filed: April 3, 1989
    Date of Patent: August 6, 1991
    Assignee: Monsanto Company
    Inventors: Leslie D. Bell, Ernest J. Mayer, Mark O. Palmier, H. Eser Tolunay, Thomas G. Warren, Tze-Chein Wun
  • Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
    Patent number: 4963357
    Abstract: A modified tissue plasminogen activator having an improved in vivo half-life characterized in that the normal protein moiety of 527 amino acids is mutated at the site Cys73.fwdarw.Arg.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: October 16, 1990
    Assignee: Monsanto Company
    Inventors: Leslie D. Bell, Ernest J. Mayer, Mark O. Palmier, H. Eser Tolunay, Thomas G. Warren, Tze-Chein Wun