Abstract: The present invention is directed to oral dosage forms for extended release, including a dosage form for pH independent extended release, of at least one drug to a subject. The present invention is also directed to methods of making and using the dosage forms to treat or prevent a subject for various conditions. Specific extended release formulations of crystalline clindamycin free base are also provided. The crystalline clindamycin free base oral formulations of the present invention provide a means for treating or preventing gram-positive bacterial infections with a minimal number of treatments per day, potentially, as little as once or twice per day.