Abstract: Multi-compartment envelopes and process for their manufacture from a single sheet by folding one end portion of the sheet over adjacent the medial portion of the sheet, then folding the opposite end portion of the sheet over adjacent the first end portion, securing the side edges together and cutting open the first fold forming an opening to a first pocket, the second pocket having its opening between the end of the sheet and the front panel of the first pocket. The envelopes may provide different sized pockets particularly suited for use of storage of medical x-rays in one pocket and records and information in a second pocket.