Abstract: The present disclosure is directed to antibodies or antigen-binding portions thereof that specifically bind human CCR8, polynucleotides and vectors encoding the same, and pharmaceutical compositions comprising the same. Some aspects of the disclosure are directed to methods of treating a disease or condition comprising administering the anti-CCR8 antibody to a subject in need thereof.

Abstract: The present disclosure is directed to antibodies or antigen-binding portions thereof that specifically bind human CCR8, polynucleotides and vectors encoding the same, and pharmaceutical compositions comprising the same. Some aspects of the disclosure are directed to methods of treating a disease or condition comprising administering the anti-CCR8 antibody to a subject in need thereof.

Abstract: This disclosure provides a method for inhibiting, delaying, or reducing malignant cell growth in a subject with cancer, comprising administering to the subject a combination therapy comprising an effective amount of an isolated antibody or antigen-binding fragment thereof that specifically binds to semaphorin-4D (SEMA4D) and an effective amount of an epigenetic modulating agent, e.g., a histone deacetylase (HDAC) inhibitor (HDACi) a DNA methyltransferase (DNMT) inhibitor (DNMTi), or any combination thereof. The disclosure further provides a pharmaceutical composition comprising the combination therapy.

Abstract: The present disclosure is directed to antibodies or antigen-binding portions thereof that specifically bind human CCR8, polynucleotides and vectors encoding the same, and pharmaceutical compositions comprising the same. Some aspects of the disclosure are directed to methods of treating a disease or condition comprising administering the anti-CCR8 antibody to a subject in need thereof.

Abstract: This disclosure provides a method for inhibiting, delaying, or reducing malignant cell growth in a subject with cancer, comprising administering to the subject a combination therapy comprising an effective amount of an isolated antibody or antigen-binding fragment thereof that specifically binds to semaphorin-4D (SEMA4D) and an effective amount of an epigenetic modulating agent, e.g., a histone deacetylase (HDAC) inhibitor (HDACi) a DNA methyltransferase (DNMT) inhibitor (DNMTi), or any combination thereof. The disclosure further provides a pharmaceutical composition comprising the combination therapy.

Abstract: This disclosure provides an improved method of constructing a library of polynucleotides of interest in a poxvirus, vaccinia virus vector system, where the polynucleotides of interest encode polypeptides of interest. The method comprises constructing the library in the presence of an inhibitor of poxvirus assembly, e.g., rifampicin, which allows construction of libraries with higher complexity and diversity than previous methods.

Abstract: This disclosure provides an improved method of constructing a library of polynucleotides of interest in a poxvirus, e.g., vaccinia virus vector system, where the polynucleotides of interest encode polypeptides of interest. The method comprises constructing the library in the presence of an inhibitor of poxvirus assembly, e.g., rifampicin, which allows construction of libraries with higher complexity and diversity than previous methods.

Abstract: An x-ray source can include a housing with material with an atomic number of ?42 and a thermal conductivity of ?3 W/(m*K) to assist in removing heat from the x-ray source and to block x-rays emitted in undesirable directions. An x-ray source can include a shell that is electrically conductive and that encloses at least part of a voltage multiplier without enclosing a control circuit to minimize or eliminate electromagnetic interference in the control circuitry caused by the voltage multiplier. An x-ray source can include a negative voltage multiplier, a positive voltage multiplier, and a ground plane between the negative voltage multiplier and the positive voltage multiplier. The ground plane can minimize or eliminate electromagnetic interference between the negative voltage multiplier and the positive voltage multiplier. An air-filled channel, associated with the ground plane, can reduce weight of the x-ray source.

Abstract: This disclosure provides an improved method of constructing a library of polynucleotides of interest in a poxvirus, e.g., vaccinia virus vector system, where the polynucleotides of interest encode polypeptides of interest. The method comprises constructing the library in the presence of an inhibitor of poxvirus assembly, e.g., rifampicin, which allows construction of libraries with higher complexity and diversity than previous methods.

Abstract: An x-ray source can include a housing with material with an atomic number of 42 and a thermal conductivity of ?3 W/(m*K) to assist in removing heat from the x-ray source and to block x-rays emitted in undesirable directions. An x-ray source can include a shell that is electrically conductive and that encloses at least part of a voltage multiplier without enclosing a control circuit to minimize or eliminate electromagnetic interference in the control circuitry caused by the voltage multiplier. An x-ray source can include a negative voltage multiplier, a positive voltage multiplier, and a ground plane between the negative voltage multiplier and the positive voltage multiplier. The ground plane can minimize or eliminate electromagnetic interference between the negative voltage multiplier and the positive voltage multiplier. An air-filled channel, associated with the ground plane, can reduce weight of the x-ray source.

Abstract: This disclosure provides an improved method of constructing a library of polynucleotides of interest in a poxvirus, e.g., vaccinia virus vector system, where the polynucleotides of interest encode polypeptides of interest. The method comprises constructing the library in the presence of an inhibitor of poxvirus assembly, e.g., rifampicin, which allows construction of libraries with higher complexity and diversity than previous methods.

Abstract: A system and method allows a user to view communications exchanged between other participants within an online chat room without the user becoming a participant within the online chat room. The online chat room enables ongoing exchanges of electronic communications between two or more participants whose participation within the chat room are mutually revealed to each other. A user is enabled to perceive the existence of the online chat room without the user becoming a participant within the online chat room. Selection of the online chat room by the user is received. Responsive to user selection of the online chat room and without the user becoming a participant within the online chat room, at least some of the communications exchanged between the participants within the online chat room are made perceivable to the user as the communications are exchanged.

Abstract: The invention includes a power supply 17 for an x-ray tube 49. The power supply 17 can comprise a control box 48 and a remote box 47. An electron-emitter transformer 14 can be located in the remote box 47. A box-connector cable 41 between the control box 48 and the remote box 47 can be relatively long and an x-ray tube cable 21 between the remote box 47 and an electron emitter 19 can be relatively short. This design can provide improved electrical power transfer from the power supply 17 to the x-ray tube 49. Also, electrical cable size and cost can be reduced if a high voltage source 15 is located in the remote box 47.

Abstract: A system and method allows a user to view communications exchanged between other participants within an online chat room without the user becoming a participant within the online chat room. The online chat room enables ongoing exchanges of electronic communications between two or more participants whose participation within the chat room are mutually revealed to each other. A user is enabled to perceive the existence of the online chat room without the user becoming a participant within the online chat room. Selection of the online chat room by the user is received. Responsive to user selection of the online chat room and without the user becoming a participant within the online chat room, at least some of the communications exchanged between the participants within the online chat room are made perceivable to the user as the communications are exchanged.

Abstract: A system and method allows a user to view communications exchanged between other participants within an online chat room without the user becoming a participant within the online chat room. The online chat room enables ongoing exchanges of electronic communications between two or more participants whose participation within the chat room are mutually revealed to each other. A user is enabled to perceive the existence of the online chat room without the user becoming a participant within the online chat room. Selection of the online chat room by the user is received. Responsive to user selection of the online chat room and without the user becoming a participant within the online chat room, at least some of the communications exchanged between the participants within the online chat room are made perceivable to the user as the communications are exchanged.

Abstract: A system and method allows a user to view communications exchanged between other participants within an online chat room without the user becoming a participant within the online chat room. The online chat room enables ongoing exchanges of electronic communications between two or more participants whose participation within the chat room are mutually revealed to each other. A user is enabled to perceive the existence of the online chat room without the user becoming a participant within the online chat room. Selection of the online chat room by the user is received. Responsive to user selection of the online chat room and without the user becoming a participant within the online chat room, at least some of the communications exchanged between the participants within the online chat room are made perceivable to the user as the communications are exchanged.

Abstract: The present invention is a flush unit that can quickly and safely connect to a conventional soda fountain dispenser for cleaning the drain system of the dispenser. The flush unit comprises a one-piece unitary flush block or housing, a flexible hose, and a nozzle. The flush block comprises a fluid conduit having a water inlet port and a water outlet port. The flush block further comprises a plug port for plugging the syrup outlet port of a conventional back block. The water inlet and plug ports are spaced to engage with the water and syrup outlet ports, respectively, of the back block. The flush block further comprises a fastener adapted to engage with a fastener of the back block. The flexible hose has a first end connected by a fastener to the water outlet port of the flush block and a second end connected to the nozzle. The present invention allows a person to quickly connect the flush unit to a conventional dispenser and flush the drain system of the dispenser using its own hydrostatic water source.

Abstract: A system and method allows a user to view communications exchanged between other participants within an online chat room without the user becoming a participant within the online chat room. The online chat room enables ongoing exchanges of electronic communications between two or more participants whose participation within the chat room are mutually revealed to each other. A user is enabled to perceive the existence of the online chat room without the user becoming a participant within the online chat room. Selection of the online chat room by the user is received. Responsive to user selection of the online chat room and without the user becoming a participant within the online chat room, at least some of the communications exchanged between the participants within the online chat room are made perceivable to the user as the communications are exchanged.

Abstract: The invention relates generally to a system and method for testing fuel evaporative systems, and more particularly to a stand-alone tank tester system (and method) for testing vehicle fuel tank integrity. Furthermore, a self-contained calibration tank with switchable leak sizes for calibrating the tank tester to multiple leak sizes is provided. Constant flow and vacuum methods for testing fuel tank integrity are also provided.

Abstract: The present invention is a flush unit that can quickly and safely connect to a conventional soda fountain dispenser for cleaning the drain system of the dispenser. The flush unit comprises a one-piece unitary flush block or housing, a flexible hose, and a nozzle. The flush block comprises a fluid conduit having a water inlet port and a water outlet port. The flush block further comprises a plug port for plugging the syrup outlet port of a conventional back block. The water inlet and plug ports are spaced to engage with the water and syrup outlet ports, respectively, of the back block. The flush block further comprises a fastener adapted to engage with a fastener of the back block. The flexible hose has a first end connected by a fastener to the water outlet port of the flush block and a second end connected to the nozzle. The present invention allows a person to quickly connect the flush unit to a conventional dispenser and flush the drain system of the dispenser using its own hydrostatic water source.