Patents by Inventor Ernesto A. Torres
Ernesto A. Torres has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11531029Abstract: Disclosed are compositions and methods for the detection of a Flavivirus infection. In some embodiments, the method comprises detecting a recent Flavivirus infection by measuring the amount of anti-NS1 IgG3. In other embodiments, the method comprises detecting a prior Dengue virus infection in a subject previously immunized with a Dengue virus vaccine comprising one or more non-Dengue Flavivirus proteins.Type: GrantFiled: May 8, 2018Date of Patent: December 20, 2022Assignee: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Ernesto Torres De Azeved Marques, Jr., Eduardo Nascimento, Albert Icksang Ko, Donald S. Burke
-
Publication number: 20210181199Abstract: Disclosed are compositions and methods for the detection of a flavivirus infection. In some embodiments, the method comprises detecting a recent flavivirus infection by measuring the amount of anti-NS1 IgG3. In other embodiments, the method comprises detecting a prior Dengue virus infection in a subject previously immunized with a Dengue virus vaccine comprising one or more non-Dengue flavivirus proteins.Type: ApplicationFiled: May 8, 2018Publication date: June 17, 2021Applicants: University of Pittsburgh--of the Commonwealth System of Higher Education, Yale UniversityInventors: Ernesto Torres De Azeved MARQUES, Jr., Eduardo NASCIMENTO, Albert Icksang KO, Donald S. BURKE
-
Patent number: 10888612Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.Type: GrantFiled: September 28, 2018Date of Patent: January 12, 2021Assignee: The Johns Hopkins UniversityInventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
-
Publication number: 20200188503Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.Type: ApplicationFiled: September 28, 2018Publication date: June 18, 2020Inventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
-
Publication number: 20190015499Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.Type: ApplicationFiled: September 28, 2018Publication date: January 17, 2019Inventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
-
Patent number: 10124052Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.Type: GrantFiled: July 7, 2016Date of Patent: November 13, 2018Assignee: FUNDACAO OSWALDO CRUZInventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
-
Publication number: 20180228886Abstract: Disclosed herein are isolated flavivirus polypeptides comprising an amino acid sequence at least 75% identical to one of SEQ ID NOs: 1-11, or a nucleic acid encoding the polypeptide, or a viral like particle encoding the polypeptide, wherein the polypeptide does not comprise the amino acid sequence of a full-length flavivirus NS1 polypeptide. Methods of using these polypeptides are also disclosed, such as for preventing, treating, or determining the prognosis of a flavivirus infection.Type: ApplicationFiled: October 31, 2016Publication date: August 16, 2018Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Ernesto Torres De Azeved Marques, Eduardo Jose Moura do Nascimento, Guangchao Gu
-
Publication number: 20160324953Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.Type: ApplicationFiled: July 7, 2016Publication date: November 10, 2016Inventors: Ernesto Torres de Azevedo MARQUES, Rafael DHALIA, Romulo MACIEL FILHO
-
Patent number: 9393296Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.Type: GrantFiled: October 26, 2010Date of Patent: July 19, 2016Assignee: Fundacao Oswaldo CruzInventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
-
Publication number: 20120308603Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralising antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunised with pL/YFE survived the challenge.Type: ApplicationFiled: October 26, 2010Publication date: December 6, 2012Applicant: FUNDAÇÃO OSWALDO CRUZInventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
-
Publication number: 20070259721Abstract: A steering assembly has a yoke and an axially compliant intermediate shaft having an elastomeric coupling fitted concentrically to the yoke for rotation about an axis. Preferably, a rigid sleeve of the shaft has a cylindrical portion that fixes concentrically to an end portion of a shaft element that extends longitudinally along the axis. Two diametrically opposite tabs of the sleeve project radially outward from the cylindrical portion. A resiliently flexible isolator is preferably molded to the sleeve and circumferentially covers the tabs and the cylindrical portion. The isolator preferably has two diametrically opposite ears located circumferentially between two diametrically opposite cover segments that substantially cover the tabs. The tabs generally prevent rotation of the shaft with respect to the yoke in case of isolator failure due to the excessive torque. Each ear preferably has a lobe that projects axially beyond the sleeve for enhancing axial compliancy of the intermediate shaft.Type: ApplicationFiled: April 26, 2007Publication date: November 8, 2007Inventors: Kristina C. Scrimpsher, Troy Daenzer, Gary A. Novotny, Rogelio I. Macias Perez, Ernesto Torres, Andrew Maynes
-
Patent number: 6695136Abstract: An automobile cigarette case with electrical lighter for dispensing lit cigarettes to the driver of an automobile, having a substantially rectangular case housing which is selectively mountable on the dashboard of an automobile. The case housing contains an electric lighter having an electrical cord which terminates in a lighter adaptor which may be plugged into a standard cigarette lighter outlet for powering of the electric lighter. The case with electrical lighter has a cigarette passageway which holds a plurality of cigarettes and directs and biases the cigarettes toward the electric lighter whereupon they are ignited. After the cigarette has been ignited, a coiled lighter spring is allowed to expand, and thereby raises the unlit end of the cigarette so that it partially protrudes from an opening on top of the case housing, where it may be easily grasped by a user.Type: GrantFiled: January 10, 2003Date of Patent: February 24, 2004Inventor: Ernesto Torres
-
Patent number: 6610084Abstract: A shapeable, glycerine-free cold pack for providing cold therapy, and a method of producing the same, are provided. The pack comprises a plurality of encapsulated units, wherein a mixture of an NaCl based salt dissolved in water is encapsulated in polyacrylamide. An impermeable enclosure contains the encapsulated units or mini-gels to form the pack, which is pliable over a range of temperatures applicable to cold therapy.Type: GrantFiled: September 18, 2001Date of Patent: August 26, 2003Assignee: CleanAIR Systems Inc.Inventor: Ernesto A. Torres