Patents by Inventor Ernesto FEDELE

Ernesto FEDELE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds having a selective PDE4D inhibiting activity
    Patent number: 10017480
    Abstract: Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, —CH3; R??—CH3, CHF2, X=formula (II) (III) (IV) (V) Y=—CO; —C?O(CH2), —CH(OH)—CH2, —CH2—C?O, —CH2—CH2—C?O; —CH2—CH(OH)—CH2, —CH2—CH(OCOR1)—CH2 NR2? —N(CH2—CH2OH)2, formula (VI) (VII) (VIII) (IX) (X) (XI) R1=optionally substituted C1-C8 alkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C1-C3 alkyl, more preferably CH3; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: July 10, 2018
    Assignees: UNIVERSITA DEGLI STUDI DI GENOVA, THE TRUSTEES OF COLUMBIA UNIVERSITY, MAASTRICHT UNIVERSITY
    Inventors: Olga Bruno, Chiara Brullo, Alessia Romussi, Ernesto Fedele, Roberta Ricciarelli, Ottavio Arancio, Jos Prickaerts
  • NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY
    Publication number: 20160355489
    Abstract: Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, —CH3; R?=—CH3, CHF2, X=formula (II) (III) (IV) (V) Y=—CO; —C?O(CH2), —CH(OH)—CH2, —CH2—C?O, —CH2—CH2—C?O; —CH2—CH(OH)—CH2, —CH2—CH(OCOR1)—CH2 NR2=—N(CH2—CH2OH)2, formula (VI) (VII) (VIII) (IX) (X) (XI) R1=optionally substituted C1-C8 alkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C1-C3 alkyl, more preferably CH3; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.
    Type: Application
    Filed: February 10, 2015
    Publication date: December 8, 2016
    Inventors: Olga BRUNO, Chiara BRULLO, Alessia ROMUSSI, Ernesto FEDELE, Roberta RICCIARELLI, Ottavio ARANCIO, Jos PRICKAERTS