Patents by Inventor Ernesto Menta

Ernesto Menta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proteasome inhibitors and methods of using the same
    Patent number: 9233115
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: January 12, 2016
    Assignee: Millennium Pharmaceuticals Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Proteasome Inhibitors And Methods Of Using The Same
    Publication number: 20140088042
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Application
    Filed: July 24, 2013
    Publication date: March 27, 2014
    Applicant: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Proteasome inhibitors and methods of using the same
    Patent number: 8546608
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: October 1, 2013
    Assignee: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Bis-platinum complexes with antitumor activity
    Patent number: 8426625
    Abstract: A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of —B—, —B—(CH2)r—B—, —B—(CH2)r—B—(CH2)z—B—, wherein r and z are an integer from 2 to 8, B is a —NR1— or —N(R2)2+1/pQ?p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q?p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO? wherein R3 has the same meanings as R, independently from one another and R4—O—SO3? wherein R4 is (C2-C14)alkyl with the proviso that, when Q?p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: April 23, 2013
    Assignee: Cell Therapeutics, Inc.
    Inventors: Alberto Bernareggi, Mario Grugni, Giulio Mariotti, Ernesto Menta, Gianluca Pardi, Paolo Pavesi, Gabriella Pezzoni, Paolo Nicoli, Sergio De Munari
  • Proteasome inhibitors and methods of using the same
    Patent number: 8283367
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: October 9, 2012
    Assignee: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Germano D'Arasmo, Ernesto Menta, Ambrogio Oliva
  • Proteasome Inhibitors and Methods of Using the Same
    Publication number: 20120041196
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Application
    Filed: September 30, 2011
    Publication date: February 16, 2012
    Applicant: CEPHALON, INC.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassará, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Proteasome inhibitors and methods of using the same
    Patent number: 8058262
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: November 15, 2011
    Assignee: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Proteasome Inhibitors and Methods of Using the Same
    Publication number: 20110144033
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Application
    Filed: February 3, 2011
    Publication date: June 16, 2011
    Applicant: CEPHALON, INC.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Proteasome inhibitors and methods of using the same
    Patent number: 7915236
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: March 29, 2011
    Assignee: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Bis-Platinum Complexes With Antitumor Activity
    Publication number: 20100292322
    Abstract: A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of —B—, —B—(CH2)r—B—, —B—(CH2)r—B—(CH2)z—B—, wherein r and z are an integer from 2 to 8, B is a —NR1— or —N(R2)2+ 1/pQ?p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q?p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO? wherein R3 has the same meanings as R, independently from one another and R4—O—SO3? wherein R4 is (C2-C14)alkyl with the proviso that, when Q?p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.
    Type: Application
    Filed: December 21, 2006
    Publication date: November 18, 2010
    Inventors: Alberto Bernareggi, Mario Grugni, Giulio Mariotti, Ernesto Menta, Gianluca Pardi, Paolo Pavesi, Gabriella Pezzoni, Paolo Nicoli, Sergio De Munari
  • PROTEASOME INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20090291918
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Application
    Filed: July 1, 2009
    Publication date: November 26, 2009
    Applicant: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Antitumor uses of compound
    Publication number: 20090130229
    Abstract: The use of an arylidene 2-indolinone derivative for treating tumors involving Met, PDGF-R, FGF-RI, FGF-R3 or Kit tyrosine kinases, or a Ret oncoprotein which includes a MEN2-associated mutation is disclosed.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 21, 2009
    Applicants: Cell Therapeutics, Inc., Instituto Nazionale per lo Studio e la Cura dei Tumori
    Inventors: Cinzia Lanzi, Giuliana Cassinelli, Giuditta Cuccuru, Marco A. Pierotti, Franco Zunino, Ernesto Menta
  • Proteasome inhibitors and methods of using the same
    Publication number: 20090075936
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
    Type: Application
    Filed: November 6, 2008
    Publication date: March 19, 2009
    Applicant: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Germano D'Arasmo, Ernesto Menta, Ambrogio Oliva
  • Proteasome inhibitors and methods of using the same
    Patent number: 7468383
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
    Type: Grant
    Filed: February 9, 2006
    Date of Patent: December 23, 2008
    Assignee: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Germano D'Arasmo, Ernesto Menta, Ambrogio Oliva
  • Use of Diketodithiopiperazine Antibiotics for the Preparation of Antiangiogenic Pharmaceutical Compositions
    Publication number: 20080255099
    Abstract: The invention relates to the use of diketodithiopiperazine antibiotics, in particular chaetocin and gliotoxin, for the preparation of pharmaceutical compositions for antitumor therapy.
    Type: Application
    Filed: December 14, 2005
    Publication date: October 16, 2008
    Applicant: Cell Therapeutics, Inc.
    Inventors: Sergio De Munari, Mario Grugni, Ernesto Menta, Mara Cassin, Gennaro Colella
  • Proteasome inhibitors and methods of using the same
    Patent number: 7223745
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: May 29, 2007
    Assignee: Cephalon, Inc.
    Inventors: Sankar Chatterjee, Mohamed Iqbal, Ernesto Menta, Ambrogio Oliva
  • Antitumor compound and therapeutic uses thereof
    Publication number: 20060258731
    Abstract: The use of an arylidene 2-indolinone derivative for treating tumors involving Met, PDGF-R, FGF-RI, FGF-R3 and Kit tyrosine kinases, or the oncoproteins of Ret family is disclosed. The invention also provides pharmaceutical compositions comprising laid arylidene 2-indolinone derivative as well as a kit comprising, in separate containers, said derivative and an anti-cancer or anti-tumor agent.
    Type: Application
    Filed: July 22, 2003
    Publication date: November 16, 2006
    Inventors: Cinzia Lanzi, Giuliana Cassinelli, Giuditta Cuccuru, Marco Pierotti, Franco Zunino, Ernesto Menta
  • Proteasome inhibitors and methods of using the same
    Publication number: 20060189806
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
    Type: Application
    Filed: February 9, 2006
    Publication date: August 24, 2006
    Applicant: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo Cassara, Germano D'Arasmo, Ernesto Menta, Ambrogio Oliva
  • Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells
    Publication number: 20060122387
    Abstract: The compounds of formula (I) wherein A and R1-R5 are as defined in the description, are inhibitors of Vascular Endothelial Growth Factor and are useful as angiogenesis inhibitors and antiproliferative agents.
    Type: Application
    Filed: June 12, 2003
    Publication date: June 8, 2006
    Inventors: Ernesto Menta, Giovanni Da Re, Mario Grugni
  • 2-(1H-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity
    Patent number: 6987122
    Abstract: 2-(1H-Indol-3-yl)-2-oxo-acetamide derivatives of formula (I) having antitumor activity in particular against solid tumors, specifically colon and lung tumors.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 17, 2006
    Assignee: Novuspharma S.p.A.
    Inventors: Ernesto Menta, Nicoletta Pescalli