Patents by Inventor Ernesto Santandrea

Ernesto Santandrea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of noroxymorphone
    Patent number: 10927122
    Abstract: The present invention relates to the improved synthesis of noroxymorphone of formula (III). Particularly, the invention shows a way how to reduce the impurity level in the product avoiding lengthy purification steps.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: February 23, 2021
    Assignee: SIEGFRIED AG
    Inventors: Ernesto Santandrea, Beat Theodor Weber, Andreas Boudier, Oliver Geiseler, Patrick Jeger
  • SYNTHESIS OF NOROXYMORPHONE
    Publication number: 20200385397
    Abstract: The present invention relates to the improved synthesis of noroxymorphone of formula (III). Particularly, the invention shows a way how to reduce the impurity level in the product avoiding lengthy purification steps.
    Type: Application
    Filed: November 29, 2018
    Publication date: December 10, 2020
    Inventors: Ernesto SANTANDREA, Beat Theodor WEBER, Andreas BOUDIER, Oliver GEISELER, Patrick JEGER
  • N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
    Patent number: 8846741
    Abstract: The present invention relates to N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives of the formula (I), (II), (III) or (IV) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such N-substituted amino-benzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, and the use of such N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives for therapeutic purposes. The N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives are GlyT1 inhibitors.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: September 30, 2014
    Assignees: AbbVie Inc., AbbVie Deutschland GmbH & Co. KG
    Inventors: Wilhelm Amberg, Udo Lange, Frauke Pohlki, Ernesto Santandrea, Charles Hutchins
  • Beta-3 receptor ligands and their use in therapy
    Patent number: 8354412
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: January 15, 2013
    Assignee: Universita' Degli Studi di Bari
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
  • Beta-3 receptor ligands and their use in therapy
    Publication number: 20110288104
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Application
    Filed: August 3, 2011
    Publication date: November 24, 2011
    Applicant: UNIVERSITA' DEGLI STUDI DI BARI
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
  • Beta-3 receptor ligands and their use in therapy
    Patent number: 8017613
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: September 13, 2011
    Assignee: Universita' Degli Studi Di Bari
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
  • BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY
    Publication number: 20100075977
    Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.
    Type: Application
    Filed: August 3, 2007
    Publication date: March 25, 2010
    Inventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea