Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Abstract: The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode. Devices and methods for using this electrochemical sensor are also disclosed.

Abstract: A solid contact ion-selective electrode with a substantially hydrophobic solid contact. Tetradecyl-substituted poly(3,4-ethylenedioxythiophene) (PEDOT-C14) with tetrakispentafluorophenyl borate (TPFPhB) as counter ion can be used as the hydrophobic solid contact, in combination with various sensing membranes used in ion-selective electrodes. Other PEDOT derivatives that can be used include, but are not limited to, PEDOT-C12, PEDOT-C10, PEDOT-C8, or PEDOT-C4. Other counter ions that can be used include tetrakis(4-chlorophenyl) borate, tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, and heptadecafluorooctanesulfonate (HDFOS).

Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Abstract: The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode. Devices and methods for using this electrochemical sensor are also disclosed.

Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Abstract: A method and system for electrochemical detection of an analyte in a vapor or gas sample is provided. The method and system include exposing a vapor or gas sample to an electrochemical sensor comprising one or more electrodes and a coating that surrounds the one or more electrodes, which coating is capable of partitioning the analyte directly from the vapor or gas sample. The method and system include detecting an oxidation/reduction current during the exposing, wherein the detected current relates to a concentration of analyte in the vapor or gas sample.

Abstract: Sensors and methods of making the same are disclosed. Sensors are microfabricated with multiple working electrodes and a single, common counter electrode. The multiple working electrodes can be fabricated in different geometrical configurations for advantageously analyzing multiple components simultaneously in the same microcell sensor. Furthermore, sensors according to certain embodiments of the invention include openings to allow photometric analysis along with electroanalytical methods.

Abstract: Disclosed are a copolymer composition comprising a substituted halo-polymer wherein from about 0.01% to about by weight of the halo moieties therein are replaced with piperazine, and a flexible plastic film made from the copolymer. The copolymer is inherently conductive.

Abstract: The invention relates to new crown ether derivatives of the general Formula I ##STR1## and a process for the preparation thereof wherein Z.sup.1 is a group of the general Formula ##STR2## R.sub.a and R.sub.b may be the same or different and R.sub.a represents an alkyl group having 1-4 carbon atoms and R.sub.b is an alkyl group having 1-20 carbon atoms.The new crown ethers are useful in the preparation of ion-selective electrodes having a long lifetime.

Abstract: New crown ether derivatives of formula (I) ##STR1## wherein R stands for hydrogen or C.sub.1-4 alkyln stands for 1,2,X stands for oxygen, sulphur or a NH-groupY represents hydrogen or nitroZ represents a chemical bond, --CH.sub.2 --, --(CH.sub.2).sub.2-4 --, --CH.sub.2 OCH.sub.2 --, --CH.sub.2 SCH.sub.2 --, ##STR2## or a group of the formula ##STR3## suitable for forming cation complexes, process for the preparation thereof and alkali or alkali earth metal ion-selective membrane electrodes containing said compounds are described.