Patents by Inventor Erno M. Keskeny

Erno M. Keskeny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LOW ABUK OXYCODONE, ITS SALTS AND METHODS OF MAKING SAME
    Publication number: 20140206871
    Abstract: A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.
    Type: Application
    Filed: March 21, 2014
    Publication date: July 24, 2014
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Erno M Keskeny, James J. Mencel, Jen-Sen Dung
  • Low ABUK oxycodone, its salts and methods of making same
    Patent number: 8703950
    Abstract: A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 22, 2014
    Assignee: Johnson Matthey Public Limited Co.
    Inventors: Erno M. Keskeny, James J. Mencel, Jen-Sen Dung
  • LOW ABUK OXYCODONE, ITS SALTS AND METHODS OF MAKING SAME
    Publication number: 20120259118
    Abstract: A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.
    Type: Application
    Filed: July 1, 2011
    Publication date: October 11, 2012
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: Erno M. Keskeny, James J. Mencel, Jen-Sen Dung
  • Method for making analgesics
    Patent number: 7851482
    Abstract: Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration.
    Type: Grant
    Filed: October 3, 2007
    Date of Patent: December 14, 2010
    Assignee: Johnson Matthey Public Limited Compnay
    Inventors: Jen-Sen Dung, Erno M. Keskeny, James J. Mencel
  • PREPARATION OF OXYCODONE
    Publication number: 20080306265
    Abstract: A method of purifying oxycodone or a salt thereof includes the steps of: a) preparing a solution including the oxycodone or salt thereof in a solvent, the solution having a pH less than 6, and; b) maintaining the solution at a temperature of at least 55° C. for a period of at least 1 hour; wherein the step of maintaining is performed in the absence of hydrogenation reagents.
    Type: Application
    Filed: August 15, 2008
    Publication date: December 11, 2008
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Michael Lawrence Casner, Jen-Sen Dung, Erno M. Keskeny, Jin Luo
  • Preparation of oxycodone
    Patent number: 7153966
    Abstract: A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of: a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixture to less than 6; and subsequently b) exposing the mixture to hydrogenation reagents for a period of at least 1 hour.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: December 26, 2006
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Michael Lawrence Casner, Jen-Sen Dung, Erno M. Keskeny, Jin Luo