Patents by Inventor Ernst Bohnlein

Ernst Bohnlein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
    Patent number: 6017761
    Abstract: This invention provides a method for obtaining a recombinant retroviral packaging cell capable of producing retroviral vectors as well as the recombinant packaging cell obtained by the method. Also provided is a method of producing recombinant retroviral particles obtained by introducing into the packaging cells obtained according to the methods disclosed herein, a recombinant retroviral vector and propagating the resulting producer cells under conditions favorable for the production and secretion of retroviral vector supernatant. The retroviral supernatant produced by these methods also is claimed herein. This invention further provides a method for screening retroviral vector supernatant for high transduction efficiency and methods for producing retroviral vector supernatant for transducing cells with high efficiency in gene therapy applications.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: January 25, 2000
    Assignee: SyStemix, Inc.
    Inventors: Richard J. Rigg, Jingyi Chen, Jonathan S. Dando, Ivan Plavec, Sean P. Forestell, Ernst Bohnlein
  • Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
    Patent number: 5910434
    Abstract: This invention provides a method for obtaining a recombinant retroviral packaging cell capable of producing retroviral vectors and the recombinant packaging cell obtained by the method. Also provided is a method of producing recombinant retroviral particles obtained by introducing into the packaging cells obtained according to the methods disclosed herein, a recombinant retroviral vector and propagating the resulting producer cells under conditions favorable for the production and secretion of retroviral vector supernatant. The retroviral supernatants produced by these methods also is claimed herein. This invention further provides a method for screening retroviral vector supernatant for high transduction efficiency and methods for producing retroviral vector supernatant for transducing cells with high efficiency in gene therapy applications.
    Type: Grant
    Filed: December 15, 1995
    Date of Patent: June 8, 1999
    Assignee: SyStemix, Inc.
    Inventors: Richard J. Rigg, Jingyi Chen, Jonathan S. Dando, Ivan Plavec, Sean P. Forestell, Ernst Bohnlein