Patents by Inventor Ernst Felder
Ernst Felder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5733528Abstract: New compounds endowed with a chelating property for paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI) are described. A method of obtaining images of organs and tissues of a human or animal body by means of nuclear magnetic resonance is also described.Type: GrantFiled: May 30, 1995Date of Patent: March 31, 1998Assignee: Dibra S.p.A.Inventors: Ernst Felder, Pier Lucio Anelli, Mario Virtuani, Andrea Beltrami, Marco Lolli
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Patent number: 5710271Abstract: A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diasteromeric salts.Type: GrantFiled: June 7, 1995Date of Patent: January 20, 1998Assignee: Dibra S.p.A.Inventors: Ernst Felder, Giorgio Ripa, Carlo Distaso
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Patent number: 5695742Abstract: This invention refers to injectable aqueous formulations containing radiopaque contrast agents useful for X-ray imaging of human or animal body. This invention specially deals with injectable aqueous solutions of mixtures of non-ionic and water-soluble iodinated aromatic compounds preferably constituted by: a) compounds comprising an aromatic nucleus at least triiodo-substituted; b) compounds comprising at least two aromatic nuclei variably bound together, each one at least triiodo substituted.Type: GrantFiled: May 25, 1995Date of Patent: December 9, 1997Assignee: Dibra S.p.A.Inventors: Ernst Felder, Christoph de Haen
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Patent number: 5182370Abstract: Comounds having the formula ##STR1## wherein: a is 2 or 3; b is an integer from 0 to 4;Me.sup.(a+) is an ion of an element of atomic number from 57 to 70 or an ion of a transition metal of atomic number 21-29, 42 or 44;E.sup.(b+) is one or more physiologically biocompatible cation of an inorganic or an organic base or amino acid, said cation representing a total positive charge of b units;S is the group --A--O--R wherein:A is --(CH.sub.2).sub.m --; --CH.sub.2 --C(CH.sub.3).sub.2 --; m is an integer from 1 to 5; R is H; linear or branched alkyl of 1 to 8 carbon atoms, said carbon atoms being unsubstituted or substituted by one or more hyroxy group; aralkyl of 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, amino, hydroxy or trifluoromethyl; (poly)-oxa-alkyl of 1 to 10 oxygen atoms and from 3 to 30 carbon atoms;R.sub.1 is R.sub.2 or --CH.sub.2 COOZ; --CH(CH.sub.3)COOZ; --(CH.sub.2).sub.n --N(CH.sub.2 COOZ).sub.Type: GrantFiled: December 13, 1989Date of Patent: January 26, 1993Assignee: Bracco Industria Chimica S.p.A.Inventors: Ernst Felder, Luciano Fumagalli, Fulvio Uggeri, Giorgio Vittadini
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Patent number: 5132409Abstract: Macrocyclic derivatives of 1,4,7,10-tetraazacyclododecane of general formula (I) hereinbelow, wherein A is a group of formula (II) hereinbelow, in which R is H or alkyl or optionally substituted benzyl or a H(OCH.sub.2 CH.sub.2).sub.1-4-, Me(OCH.sub.2 CH.sub.2).sub.1-4-, or Et(OCH.sub.2 CH.sub.2).sub.1-4- group, X or O--R.sub.1, in which R.sub.1 is H or alkyl, hydroxyalkyl, alkoxyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group or X is --NR.sub.2 R.sub.3, in which R.sub.2 and R.sub.3 are H or alkyl, hydroxyalkyl, alkoxyalkyl or alkoxyhydroxyalkyl, and B.sub.1, B.sub.2 and B.sub.3 have the same meanings as A or are H or a group of formula (III) hereinbelow, in which R.sub.4 is H or alkyl, Y is a O--R.sub.5 group, wherein R.sub.5 is H or alkyl, hydroxyalkyl, alkoxyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group, or Y is a --NR.sub.6 R.sub.7 group, wherein R.sub.6 and R.sub.Type: GrantFiled: November 27, 1989Date of Patent: July 21, 1992Assignee: Bracco Industria Chimica S.p.A.Inventors: Ernst Felder, Carlo Musu, Luciano Fumagalli, Fulvio Uggeri
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Patent number: 5023379Abstract: A process for the production of hydroxyamines of the formula IR.sup.1 --CH(OH)--CH(NHR.sup.3)--R.sup.2 (I)whereinR.sup.1 and R.sup.2 independently of one another are H or CH.sub.2 OH andR.sup.3 is H, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -hydroxyalkyl comprising reacting an oxo compound with an amine and reducing the resultant ketimine with a reducing agent.Type: GrantFiled: March 12, 1990Date of Patent: June 11, 1991Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Ernst Felder, Michael Romer, Hans Bardonner, Hartmut Hartner, Wolfgang Fruhstorfer
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Patent number: 4980502Abstract: Compounds suitable for NMR imaging having the formula: ##STR1## wherein a is 2 or 3;b is an integer from 0 to 4;Me.sup.(a+) is Fe.sup.(2+), Fe.sup.(3+), Gd.sup.(3+), or Mn.sup.(2+) ;E.sup.(b+) is an ion of an alkali metal, alkaline earth metal, alkyl ammonium, alkanol ammonium, polyhydroxyalkyl ammonium, or basic protonated amino acid, said ions representing a total charge of b;m is an integer from 1 to 5;R is H, alkyl with from 1 to 8 carbon atoms, alkyl with from 1 to 8 carbon atoms wherein from 1 to 5 carbons are substituted with OH; aralkyl with 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, hydroxyl, carboxyl, carboxamide, ester, SO.sub.3 H, sulfonamide, lower alkyl, lower hydroxy alkyl, amino, acylamino; (poly)oxa-alkyl with 1 to 50 oxygen atoms and from 3 to 150 carbon atoms, wherein 1 to 5 hydrogen atoms may be substituted by OH; R.sub.1 is the same as R.sub.2 oris --CH.sub.2 COOZ, --CH(CH.sub.3)COOZ, CH.sub.2 CH.sub.2 --N(CH.sub.2 COOZ).sub.Type: GrantFiled: September 25, 1989Date of Patent: December 25, 1990Assignee: Bracco Industria Chimica, S.p.A.Inventors: Ernst Felder, Fulvio Uggeri, Luciano Fumagalli, Giorio Vittadini
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Patent number: 4916246Abstract: Compounds suitable for NMR imaging having the formula: ##STR1## wherein a is 2 or 3;b is an integer from 0 to 4;Me.sup.(a+) is Fe.sup.(2+), Fe.sup.(3+), Gd.sup.(3+), or Mn.sup.(2+) ;E.sup.(b+) is an ion of an alkali metal, alkaline earth metal, alkyl ammonium, alkanol ammonium, polyhydroxyalkyl ammonium, or basic protonated amino acid, said ions representing a total charge of b;m is an integer from 1 to 5;R is H, alkyl with from 1 to 8 carbon atoms, alkyl with from 1 to 8 carbon atoms wherein from 1 to 5 carbons are substituted with OH; aralkyl with 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, hydroxyl, carboxyl, carboxamide, ester, SO.sub.3 H, sulfonamide, lower alkyl, lower hydroxy alkyl, amino, acylamino; (poly)oxa-alkyl with 1 to 50 oxygen atoms and from 3 to 150 carbon atoms, wherein 1 to 5 hydrogen atoms may be substituted by OH;R.sub.1 is the same as R.sub.2 oris --CH.sub.2 COOZ, --CH(CH.sub.3)COOZ, CH.sub.2 CH.sub.2 --N(CH.sub.2 COOZ).sub.Type: GrantFiled: January 12, 1987Date of Patent: April 10, 1990Assignee: Bracco Chimica S.p.A.Inventors: Ernst Felder, Fulvio Uggeri, Luciano Fumagalli, Giorgio Vittadini
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Patent number: 4588574Abstract: Barium sulfate suitable for the preparation of radiographic contrast agents of increased flowability and density is obtained by a high temperature treatment at 700.degree. to 1,200.degree. C. and preferably at 800.degree. to 1,000.degree. C. The barium sulfate so sintered is distinguished by a bulk density of 2.5 to 3 g/ml and its aqueous suspension, containing 200 g of barium sulfate per 100 ml, is distinguished by a viscosity of no more than 1,000 mPas. Radiographic contrast agents containing at least 200 g of sintered barium sulfate per 100 ml are outstandingly suitable for the difficult double contrast visualization of the stomach and gastric mucosa.Type: GrantFiled: July 31, 1984Date of Patent: May 13, 1986Assignee: Bracco Industria Chimica S.p.A.Inventors: Ernst Felder, Maria Zingales, deceased
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Patent number: 4503252Abstract: A method for the synthesis of serinol and serinol derivatives substituted at the nitrogen atoms by reacting a lower 1,3-dialkoxy-isopropyl halide with ammonia or an amine to form a 1,3-dialkoxy-isopropylamine and then removing the ether groups by heating with a hydrogen halide acid. The method allows the production of serinol and serinol derivatives using inexpensive starting materials in a simple manner and obtaining a high purity product which is free of interfering isomers. Novel compounds obtained by the method which are useful as pharmaceutical intermediates, X-ray contrasting agents and cytostatic or psychopharmacological drugs are also disclosed.Type: GrantFiled: November 15, 1982Date of Patent: March 5, 1985Assignee: Eprova AktiengesellschaftInventors: Ernst Felder, Sergio Bianchi, Heinrich Bollinger
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Patent number: 4352788Abstract: Compounds for use in non-ionic X-ray contrasting materials having the formula ##STR1## in which (H0).sub.2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl,R is hydrogen or methyl, andR.sub.1 is an alkyl residue with 1 to 5 carbon atoms.These compounds possess high water-solubility as well as excellent stability against hydrolysis. Methods for preparation and use of the compounds are also disclosed.Type: GrantFiled: July 30, 1980Date of Patent: October 5, 1982Assignee: Bracco Industria Chimica S.p.A.Inventors: Ernst Felder, Davide Pitre
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Patent number: 4348377Abstract: Novel, radio-opaque compounds comprising water-soluble bis-[N-{3,5-bis-(hydroxyalkylaminocarbonyl)-2,4,6-triiodo-phenyl}-N-(.alph a.-hydroxyacyl)-amino]-alkanes are disclosed for use as X-ray contrast agents. These compounds are relatively simple to synthesize, possess low toxicity and have good stability as well as resistance to hydrolysis. Methods for preparation and use of the compounds are also disclosed.Type: GrantFiled: July 30, 1980Date of Patent: September 7, 1982Assignee: Bracco Industria Chimica S.p.A.Inventors: Ernst Felder, Davide Pitre
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Patent number: 4278808Abstract: 3-Alkoxy-2-alkyl-propionic acid derivatives are prepared by catalytic hydrogenation of the acrylic acid analogs. The latter are obtained by CO treatment of lower alkyl esters of alkanoic acids having 3-6 carbon atoms in the presence of alkali metal methylate and condensation of the resulting 2-formylalkanoic acids or their alkali metal enolates with compounds of the formula X--(CH.sub.2).sub.m --Z wherein X is Cl, Br, or OH, and Z is Cl, Br, I, alkyl- or arylsulfonyl, or OH.Type: GrantFiled: September 14, 1978Date of Patent: July 14, 1981Assignee: Bracco Industria Chimica S.p.A.Inventors: Ernst Felder, Davide Pitre
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Patent number: 4246164Abstract: The subject of the invention is a process for resolving mixtures of (+)- and (-)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid into the enantiomers thereof, characterized in that N-methyl-D-glucamine [=1-deoxy-1-(methylamino)-D-glucitol] is used as the resolving agent, so that the 6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid is converted into the corresponding diastereoisomeric N-methyl-D-glucamine salt pair which, because of very different solubilities, can be separated easily and completely with high yield.Type: GrantFiled: July 6, 1979Date of Patent: January 20, 1981Assignee: Syntex CorporationInventors: Ernst Felder, Davide Pitre, Hans Zutter
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Patent number: 4139605Abstract: .alpha., .omega.-BIS-[5-(DIHYDROXYALKYL) AMINOCARBONYL-3-HYDROXYACYL-AMINO-2,4,6-TRIIODO-BENZOYL-AMINO]-OXAALKANE COMPOUNDS OF THE FORMULA ##STR1## wherein R.sub.1 is ##STR2## R and R' are hydrogen or methyl, R.sub.2 is dihydroxyalkyl having 3 or 4 carbon atoms,N is 2 or 3,M is an integer between 1 and 5, andN(m+1) is an integer between 4 and 12,Are readily soluble in water to yield injectable radiopaque contrast compositions which are well tolerated and stable. The compounds are prepared in good yields by reacting a reactive derivative of a 5-(di-hydroxyalkyl)aminocarbonyl-3-acyloxyacylamino-2,4,6-triiodo-benzoic acid with an .alpha.,.omega.-diamino-oxaalkane of the formulaR--NH--C.sub.n H.sub.2n --(O--C.sub.n H.sub.2n)--NH--R.Type: GrantFiled: February 27, 1978Date of Patent: February 13, 1979Assignee: Bracco Industria Chimica S.p.A.Inventors: Ernst Felder, Davide Pitre
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Patent number: 4044048Abstract: Compounds of the formula ##STR1## wherein R is (C.sub.m H.sub.2m O.sub.n)--OH, m being 2, 3, or 4, and n being 0 or 1, are effective and well tolerated as X-ray contrast agents in lymphography, hepatography, bronchography, cystography, and hysterosalpingography.Type: GrantFiled: May 10, 1976Date of Patent: August 23, 1977Assignee: Bracco Industria Chimica Societa per AzioniInventors: Ernst Felder, Davide Pitre
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Patent number: 4001323Abstract: Compounds of the formula ##STR1## wherein R and R.sub.1 are 1,3-dihydroxyisopropyl or 2,3-dihydroxypropyl, and R.sub.2 is hydrogen or hydroxyl, are readily water-soluble and of sufficiently low toxicity for use as radiopaque materials in the radiography of body cavities as in urography, angiography, ventriculography, and myelography.Type: GrantFiled: November 24, 1975Date of Patent: January 4, 1977Assignee: Savac AGInventors: Ernst Felder, David E. Pitre