Abstract: A transfer instrument (50), consisting of a prefilled disposable syringe, comprises a container (51) containing the liquid to be injected, a piston (52), and a piston rod (53) attached to the bottom of a capsule (54) with a tubular tip (58). This tubular tip has an inner surface (62) in the shape of a truncated cone to admit an insert (66) and an outer surface (64) in the shape of a truncated cone with a taper of 6%, capable of receiving a standard cap (59) fitted with a needle (60). A throat (73) is provided at the periphery of the insert (66) to permit the flow of the injection liquid and to obviate the need for a large dead volume.

Abstract: A device for dispensing liquids, in particular drugs, comprises a reservoir (11) provided with a neck (30) of reduced cross-section being engaged by a stopper element (16). The reservoir is completely covered by a cap (25) which has at one end a movable push button (28) which abuts against the bottom portion of the reservoir (10). In order to transfer the device from its storage position to its activated position, the operator must press on the push button (28) in such a way that the stopper element (16) penetrates into the interior of the reservoir beyond the neck of reduced crosssection (30). This device can be used as an injection syringe, a spray dispenser, or an applicator for the skin or eyes.

Abstract: The device comprises a cylindrical ampoule which is closed at one end and opened at the other end. The ampoule has a relatively large circular cylindrical zone adjacent the closed end and a relatively small cylindrical zone disposed between the relatively large cylindrical zone and the open end of the ampoule. A piston valve engages the open end of the ampoule to provide sealing engagement and dispensing of the liquid contents when desired. An intermediary stopper engages the relatively small cylindrical zone, when the stopper is in a storage position, to divide the ampoule into first and second storage compartments. The stopper is shaped to provide tight sealing engagement with the relatively small circular cylindrical zone while providing at least one opening, between its lateral surface and the interior wall of the ampoule, for allowing passage and mixing the substances contained in the compartments, when it is positioned in the relatively large circular cylindrical zone.

Abstract: A prefilled ampoule-syringe comprising an ampoule and an ampoule body having a single open end and a neck located near the single open end, the neck having a smaller transverse inner dimension then said body. A stopper, associated with an external capsule, has an internal conduit to allow communication between the interior of the ampoule body and the injection tip, the stopper being arranged for axial movement within said neck from a closed to an open position. An upper part of the stopper having at least one continuous annulus surface having a larger outer dimension than the inner dimension of the ampoule neck so as to be in a sealing compressed condition in the closed position and having a smaller outer dimension than the inner dimension of the ampoule body so as to be in a partly expanded condition in said open position to permit the flow of liquid from the ampoule body to the tip.

Abstract: The present invention relates to a prefilled syringe comprising a reservoir containing a single dose of medicine to be injected.The principle elements of this syringe are the reservoir (10), a blocking element (12), a capsule (13) integral with this element, a needle (14), a needle-protector (15) and a cap (16). The cap (16), in place on the reservoir, makes it possible for the operator, by pressing on this cap to make the blocking element penetrate towards the interior of the reservoir a sufficient distance to cause the precise bubble removal of the syringe. To this end, the cap is connected to the capsule (13) by a base (36) comprising a zone of reduced resistance.

Abstract: A prefilled ampoule-syringe including an ampoule body having a smaller inner dimension than the body and a stopper means associated with an external capsule for closing the ampoule. The stopper is provided with an internal conduit having at least one transverse branch opening into a longitudinal branch between the interior of the capsule body and a needle-holding tip. The capsule is arranged for actual movement from a position within the neck where it is in a closed position to an open injection position within the ampoule body. When the capsule is in the position in the neck of the ampoule, the contents of the ampoule are in contact only with the walls of the ampoule and the inner surface of the stopper which faces into the neck. When the stopper is moved to injection position, the contents of the ampoule pass through the transverse passage and down the longitudinal passage to the needle holding tip for injection into a patient.

Abstract: The present invention relates to a method for manufacturing a prefilled single-dose syringe.It comprises a station (12) for supplying the ampoules (2), a station (13) for pregassing the ampoules (2), a station (14) for filling-gassing the ampoules (2), a station (15) for supplying the injector bodies (3), equipped with their needle-holder covering cap (4), a station (16) for assembling the ampoules (2) and the injector bodies (3), a station (19) for final control of the syringe (1), a station (22) for release of the syringes accepted by the final control station, a station (20) for quantitative control of gassing of the syringes, a station (21) for qualitative control of gassing of the syringes.

Abstract: A prefilled ampoule-syringe of unitary dose comprises an ampoule being closed at one of its ends, the other end being open. The ampoule further comprises a narrowed zone. A hollow capsule is arranged at top of the opening of the ampoule. This capsule is connected to a movable stopper means comprising a stopper head and a hollow cylindrical member having a radial channel and a peripheral rim. This rim acts as a retention member during the storage and as a piston ring during the injection. In order to avoid the loss of its elasticity, the rim is located within a belt of enlarged diameter downstream from the narrowed zone during the storage.

Abstract: The prefilled single-dose syringe 10 in the application features a barrel 11 provided with an narrowed-diameter portion 27 or neck and a rim surrounding its opening; a nozzle 12 equipped with finger stubs and a needle-carrying ferrule 13 transpierced by an axial channel 31; and a stoppering device 23 featuring an elastomer stoppering cork mounted at the end of a bracing ferrule that is attached to the bottom of the nozzle. This lower end of the bracing ferrule fits onto a collar, in the shape of a truncated cone, that is part of the bottom of the nozzle. This collar serves as a support for a membrane microfilter 28, which is pressed between the opposing surfaces of the bracing ferrule and the filter-carrying ferrule.