Patents by Inventor Ernst Küsters

Ernst Küsters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical process for preparing spiroindolones and intermediates thereof
    Patent number: 9598712
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1?R,3?S)-5,7?-dichloro-6?-fluoro-3?-methyl-2?,3?,4?,9?-tetrahydrospiro[indoline-3,1?-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: March 21, 2017
    Assignee: Novartis AG
    Inventors: Michael Crowe, Michael Foulkes, Giancarlo Francese, Dominique Grimler, Ernst Kuesters, Kurt Laumen, Yunzhong Li, Changxue Lin, Jovana Nazor, Thomas Ruch, Derek Smith, Shiwei Song, Shangjun Teng
  • Aminoalkanol derivatives
    Patent number: 9415024
    Abstract: Disclosed are compounds of formula I wherein R1, R2, R5 and R6 are as defined in the claims; such compounds have interesting pharmacological properties.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: August 16, 2016
    Assignee: Novartis AG
    Inventors: Ernst Küsters, Lukas Oberer, Gottfried Sedelmeier
  • Chemical Process for Preparing Spiroindolones and Intermediates Thereof
    Publication number: 20150045562
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1?R,3?S)-5,7?-dichloro-6?-fluoro-3?-methyl-2?,3?,4?,9?-tetrahydrospiro[indoline-3,1?-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.
    Type: Application
    Filed: March 22, 2013
    Publication date: February 12, 2015
    Applicant: Novartis AG
    Inventors: Michael Crowe, Michael Foulkes, Giancarlo Francese, Dominique Grimler, Ernst Kuesters, Kurt Laumen, Yunzhong Li, Changxue Lin, Jovana Nazor, Thomas Ruch, Derek Smith, Shiwei Song, Shangjun Teng
  • AMINOALKANOL DERIVATIVES
    Publication number: 20130289127
    Abstract: Disclosed are compounds of formula I wherein R1, R2, R5 and R6 are as defined in the claims; such compounds have interesting pharmacological properties.
    Type: Application
    Filed: June 13, 2013
    Publication date: October 31, 2013
    Inventors: Ernst Küsters, Lukas Oberer, Gottfried Sedelmeier
  • Manufacture process
    Patent number: 8252310
    Abstract: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: August 28, 2012
    Assignee: Novartis AG
    Inventors: Michael Ambühl, Corine Gessier-Vial, Christa Hartmann, Daniel Kaufmann, Ernst Küsters, Ulrich Meier, Andreas Meyer, Nabila Sekkat
  • Manufacture Process
    Publication number: 20120126440
    Abstract: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 24, 2012
    Inventors: Michael Ambühl, Corine Gessier-Vial, Christa Hartmann, Daniel Kaufmann, Ernst Küsters, Ulrich Meier, Andreas Meyer, Nabila Sekkat
  • Crystal form of epothilone B and use in pharmaceutical compositions
    Patent number: 8178566
    Abstract: The invention relates to new crystal forms of epothilone B.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: May 15, 2012
    Assignee: Novartis AG
    Inventors: Ernst Küsters, Michael Mutz, Frank Stowasser
  • Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof
    Patent number: 8084487
    Abstract: The present invention relates to a process for the production of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers and of 1-carbalkoxy-4-ketoperhydroindole enantiomers.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: December 27, 2011
    Assignee: Novartis AG
    Inventors: Ernst Kuesters, Murat Acemoglu, Philipp Lustenberger, Gottfried Sedelmeier, Beat Schmitz, Gerhard Penn
  • IONIC LIQUIDS AS SOLVENTS IN HEADSPACE GAS CHROMATOGRAPHY
    Publication number: 20110185788
    Abstract: A method of using an ionic liquid as solvent in headspace gas chromatography.
    Type: Application
    Filed: April 13, 2011
    Publication date: August 4, 2011
    Inventors: Peter Koch, Ernst Küsters
  • PROCESSES FOR THE PREPARATION OF 4-OXO-OCTAHYDRO-INDOLE-1-CARBOCYCLIC ACID METHYL ESTER AND DERIVATIVES THEREOF
    Publication number: 20110144352
    Abstract: The present invention relates to a process for the production of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers and of 1-carbalkoxy-4-ketoperhydroindole enantiomers.
    Type: Application
    Filed: August 10, 2009
    Publication date: June 16, 2011
    Applicant: NOVARTIS AG
    Inventors: Ernst Kuesters, Murat Acemoglu, Philipp Lustenberger, Gottfried Sedelmeier, Beat Schmitz, Gerhard Penn
  • MICROPARTICLES PREPARED USING AN IONIC LIQUID
    Publication number: 20100239524
    Abstract: Microparticles comprising at least one active agent embedded within a biocompatible, biodegradable polymeric matrix, wherein said microparticles are prepared with an ionic liquid.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Inventors: Michael Ausborn, Thomas Kissel, Ernst Küsters
  • CRYSTAL FORM OF EPOTHILONE B AND USE IN PHARMACEUTICAL COMPOSITIONS
    Publication number: 20100160393
    Abstract: The invention relates to new crystal forms of epothilone B.
    Type: Application
    Filed: August 14, 2007
    Publication date: June 24, 2010
    Applicant: NOVARTIS AG
    Inventors: Ernst Küsters, Michael Mutz, Frank Stowasser
  • Process for the isolation and purification of epothilones
    Patent number: 7569698
    Abstract: The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the use of certain solvents for the desorption of epothilones from resins.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: August 4, 2009
    Assignee: Novartis AG
    Inventors: Ernst Kuesters, Heinz Unternaehrer
  • Ionic liquids as solvents in headspace gas chromatography
    Patent number: 7569149
    Abstract: A method of using an ionic liquid as solvent in headspace gas chromatography.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: August 4, 2009
    Assignee: Novartis AG
    Inventors: Peter Koch, Ernst Küsters
  • Epothilone derivatives
    Patent number: 7317100
    Abstract: The present invention relates to C4-demethyl-epothilones or C4-bisnor-epothilones of Formula (I), their pharmaceutical use, pharmaceutical composition containing the same and methods for their preparation.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: January 8, 2008
    Assignee: Novartis AG
    Inventors: Donatienne Denni-Dischert, Andreas Floersheimer, Ernst Kuesters, Lukas Oberer, Gottfried Sedelmeier
  • Process for the isolation and purification of epothilones
    Patent number: 6946561
    Abstract: The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the use of certain solvents for the desorption of epothilones from resins.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: September 20, 2005
    Assignee: Novartis AG
    Inventors: Ernst Küsters, Heinz Unternährer
  • Macrolides
    Patent number: 6706727
    Abstract: The composition of formula I wherein the substituents have various significances, whereby one of R2 to R4 is ethyl. They can be prepared by fermentation, or by replacement of hydroxy with chloro under simultaneous or concomitant epimerization. They are indicated for use as pharmaceuticals in the prevention or treatment of inflammatory conditions and of conditions requiring immunosuppression, optionally in combination or association with further pharmaceutically active and compatible agents, e.g. macrolactam macrolides such as pimecrolimus.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: March 16, 2004
    Assignee: Novartis AG
    Inventors: Gerhard Fleissner, Helmut Häcker, Ernst Küsters, Gerhard Penn
  • Fermentative preparation process for and crystal forms of cytostatics
    Patent number: 6656711
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: December 2, 2003
    Assignee: Novartis AG
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Küsters, Michael Mutz
  • Fermentative preparation process for and crystal forms of cytostatics
    Patent number: 6194181
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: February 27, 2001
    Assignee: Novartis AG
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Küsters, Michael Mutz