Patents by Inventor Ernst Kusters

Ernst Kusters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fermentative preparation process for and crystal forms of cytostatics
    Publication number: 20040142990
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: January 8, 2004
    Publication date: July 22, 2004
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Process for the isolation and purification of epothilones
    Publication number: 20040054188
    Abstract: The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the use of certain solvents for the desorption of epothilones from resins.
    Type: Application
    Filed: June 6, 2003
    Publication date: March 18, 2004
    Inventors: Ernst Kusters, Heinz Unternahrer
  • Macrolides
    Patent number: 6706727
    Abstract: The composition of formula I wherein the substituents have various significances, whereby one of R2 to R4 is ethyl. They can be prepared by fermentation, or by replacement of hydroxy with chloro under simultaneous or concomitant epimerization. They are indicated for use as pharmaceuticals in the prevention or treatment of inflammatory conditions and of conditions requiring immunosuppression, optionally in combination or association with further pharmaceutically active and compatible agents, e.g. macrolactam macrolides such as pimecrolimus.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: March 16, 2004
    Assignee: Novartis AG
    Inventors: Gerhard Fleissner, Helmut Häcker, Ernst Küsters, Gerhard Penn
  • Fermentative preparation process for and crystal forms of cytostatics
    Patent number: 6656711
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: December 2, 2003
    Assignee: Novartis AG
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Küsters, Michael Mutz
  • Fermentative preparation process for and crystal forms of cytostatics
    Publication number: 20030220379
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: June 12, 2003
    Publication date: November 27, 2003
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Fermentative preparation process for and crystal forms of cytostatics
    Publication number: 20030194787
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: January 8, 2003
    Publication date: October 16, 2003
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Fermentative preparation process for and crystal forms of cytostatics
    Publication number: 20020165256
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: January 29, 2002
    Publication date: November 7, 2002
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Fermentative preparation process for and crystal forms of cytostatics
    Patent number: 6194181
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: February 27, 2001
    Assignee: Novartis AG
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Küsters, Michael Mutz