Patents by Inventor Ernst-Ludwig Winnacker

Ernst-Ludwig Winnacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chaperones capable of binding to prion proteins and distinguishing the isoforms PrPc and PrPSc
    Publication number: 20050227287
    Abstract: The present invention relates to methods for the detection or isolation of prion proteins by use of chaperones specifically binding to said proteins. The invention further relates to a method for in-vitro diagnosis of a transmissible spongiform encephalopathy and to pharmaceutical compositions, preferably for the prevention or treatment of said disease.
    Type: Application
    Filed: March 27, 2002
    Publication date: October 13, 2005
    Inventors: Ernst-Ludwig Winnacker, Stefan Weiss, Frank Edenhofer, Roman Rieger
  • Nucleic acid molecules capable of distinguishing the isoforms PrPc and PrPSc of prion proteins and processes for their production
    Publication number: 20030119019
    Abstract: The invention describes a process for the identification and isolation of nucleic acid molecules capable of distinguishing the isoforms PrPc and PrPSc of prion proteins as well as nucleic acid molecules obtainable by this process. Furthermore, pharmaceutical compositions and diagnostic compositions are described which comprise nucleic acid molecules specifically binding prion protein isoforms as well as diagnostic methods using such molecules.
    Type: Application
    Filed: July 3, 2002
    Publication date: June 26, 2003
    Inventors: Ernst-Ludwig Winnacker, Stefan Weiss, Michael Famulok
  • Chaperones capable of binding to prion proteins and distinguishing the isoforms PrPc and PrPsc
    Patent number: 6451541
    Abstract: The present invention relates to methods for the detection or isolation of prion proteins by use of chaperones specifically binding to said proteins. The invention further relates to a method for in vitro diagnosis of a transmissible spongiform encephalopathy and to pharmaceutical compositions, preferably for the prevention or treatment of said disease.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: September 17, 2002
    Inventors: Ernst-Ludwig Winnacker, Stefan Weiss, Frank Edenhofer, Roman Rieger
  • Nucleic acid molecules that bind prion proteins and processes for the production thereof
    Patent number: 6426409
    Abstract: The invention describes a process for the identification and isolation of nucleic acid molecules capable of distinguishing the isoforms PrPc and PrPSc of prion proteins as well as nucleic acid molecules obtainable by this process. Furthermore, pharmaceutical compositions and diagnostic compositions are described which comprise nucleic acid molecules specifically binding prion protein isoforms as well as diagnostic methods using such molecules.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: July 30, 2002
    Inventors: Ernst-Ludwig Winnacker, Stefan Weiss, Michael Famulok
  • .gamma.-glutamylcysteine transferase
    Patent number: 5116749
    Abstract: The enzyme .gamma.-glutamylcysteine transferase is disclosed. .gamma.-Glutamylcysteine transferase catalyzes the transfer of .gamma.-glutamylcysteine or .gamma.-glutamycysteine S-derivates and is produced by extracting plant material from the families of Apocynaceae, Asciepladaceae, Berberidaceae, Chenopodiaceae, Caryophyllacea, Dioscoreaceae, Fumariaceae, Graminaceae, Iridaceae, Leguminosae, Menispermaceae, Papveraceae, Ranunculaceae, Rosaceae, Rubiaceae, Solanaceae or Violaceae, or tissue of algea (Phycophyta) or fungi (Mycophyta).
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: May 26, 1992
    Assignee: Consortium fur Elektrochemische Industrie GmbH
    Inventors: Erwin Grill, Susanne Loffler, Ernst-Ludwig Winnacker, Meinhard H. Zenk
  • Cysteine-rich peptides having gamma-glutamic acid and beta-alanine units, a process for their preparation and their use
    Patent number: 4883861
    Abstract: Disclosed are peptides which have the following amino acid sequence:(.gamma.-Glu-Cys).sub.n -.beta.-Alan being an integer from 2 to 11;.gamma.-Glu represents .gamma.-glutamic acid;Cys represents cysteine; and.beta.-Ala represents .beta.-alanine.A process for the preparation of these peptides is disclosed as well as processes for their use for the maintenance of hemeostasis in physiological systems, the diagnosis of tumors, and the removal of heavy metals from a chemical or physiological system which has been contaminated with heavy metal.
    Type: Grant
    Filed: March 17, 1987
    Date of Patent: November 28, 1989
    Assignee: Consortium fur Elektrochemische Industrie GmbH
    Inventors: Erwin Grill, Ernst-Ludwig Winnacker, Meinhart H. Zenk
  • High-cysteine peptides with alpha-glutamic acid units, process for their production and application of same
    Patent number: 4725670
    Abstract: A high-cysteine polypeptide having an amino acid sequence of the formula:-(.gamma.-Glu-Cys).sub.n -Glyin which,n is an integer from 4 to 7,.gamma.-Glu represents .gamma.-glutamic acid,Cys represents cysteine, andGly represents glycine,for use in pharmaceutical preparations for treating acute and chronic heavy metal poisoning. Alternatively, the polypeptides may be employed in the treatment of metal deficiency phenomena or for maintaining the homeostasis in physiological systems with respect to such metals as iron or zinc. Processes for producing the polypeptides of the invention are also disclosed.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: February 16, 1988
    Assignee: Consortium fur Elektrochemische Industrie GmbH
    Inventors: Erwin Grill, Ernst-Ludwig Winnacker, Meinhart H. Zenk