Abstract: The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.

Abstract: A method for the production of polyoxazolidinone compounds, comprising the step of reacting an isocyanate compound (A) with an epoxide compound (B) in the presence of a catalyst (C), wherein the isocyanate compound (A) comprises a isocyanate compound (A1) wherein the a isocyanate compound (A1) comprising at least two isocyanate groups (I1?2), preferred two isocyanate groups (I1=2), wherein the epoxide compound (B) comprises a epoxide compound (B1) and an epoxide compound (B2), wherein the epoxide compound (B2) is different from the epoxide compound (B1) wherein the epoxide compound (B1) comprising at least two terminal epoxide groups (F1?2), preferred two terminal epoxide groups (F1=2), linked together by a linking group (L1) and the epoxide compound (B2) comprising at least two terminal epoxide groups (F2?2)), preferred two terminal epoxide groups (F2=2), linked together by a linking group (L2), wherein the linking group (L2) comprises acyclic and covalent bonds to each other free of conjugated multiple bond

Abstract: Method for the production of polyoxazolidinone compounds, comprising the reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) having a pKb-value of ?9. The invention is also related to the resulting polyoxazolidinone compounds.

Abstract: This invention relates to novel macromers containing dithiocarbonate (or xanthate) groups, novel preformed stabilizers comprising macromers, and novel polymer polyols comprising the novel macromers and/or novel preformed stabilizers. This invention also relates to processes for the preparation of these materials. Other aspects of this invention include foams comprising the novel polymer polyols and a process for preparing foam comprising the novel polymer polyols.

Abstract: A method for the production of polyoxazolidinone compounds, comprising the step of reacting an isocyanate compound (A) with an epoxide compound (B) in the presence of a catalyst (C), wherein the isocyanate compound (A) comprises a isocyanate compound (A1) wherein the a isocyanate compound (A1) comprising at least two isocyanate groups (I1?2), preferred two isocyanate groups (I1=2), wherein the epoxide compound (B) comprises a epoxide compound (B1) and an epoxide compound (B2), wherein the epoxide compound (B2) is different from the epoxide compound (B1) wherein the epoxide compound (B1) comprising at least two terminal epoxide groups (F1?2), preferred two terminal epoxide groups (F1=2), linked together by a linking group (L1) and the epoxide compound (B2) comprising at least two terminal epoxide groups (F2?2)), preferred two terminal epoxide groups (F2=2), linked together by a linking group (L2), wherein the linking group (L2) comprises acyclic and covalent bonds to each other free of conjugated multiple bond

Abstract: The present invention relates to a method for producing a prepolymer that contains carbon-carbon multiple bonds, a polyol component A) being reacted with component B) that contains isocyanate groups and the polyol component comprising a polyether carbonate polyol that contains carbon-carbon multiple bonds.

Abstract: Method for the production of polyoxazolidinone compounds, comprising the reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) having a pKb-value of ?9. The invention is also related to the resulting polyoxazolidinone compounds.

Abstract: The invention relates to a method for producing a polyurethane polymer, comprising the step of reacting a polyol component with a polyisocyanate component, the polyol component comprising an oxymethylene polyol. The ratio of the polyol component to the polyisocyanate component is selected such that the polyurethane polymer obtained by the reaction has a content of oxymethylene groups from the oxymethylene polyol of ?11 wt. % to ?50 wt. %, preferably ?11 wt. % to ?45 wt. %, and the content of oxymethylene groups from the oxymethylene polyol is defined by means of proton resonance spectroscopy.

Abstract: The invention relates to a method for adding a compound (A) to an H-functional starting compound (BH) in the presence of a catalyst, wherein the at least one compound (A) is selected from at least one group consisting of alkylene oxide (A-1), lactone (A-2), lactide (A-3), cyclic acetal (A-4), lactam (A-5), cyclic anhydride (A-6) and oxygen-containing heterocyclic compound (A-7) different from (A-1), (A-2), (A-3), (A-4) and (A-6), wherein the catalyst comprises an organic, n-protic Brønsted acid (C), wherein n?2 and is an element of the natural numbers and the degree of protolysis D is 0<D<n, with n as the maximum number of transferable protons and D as the calculated proton fraction of the organic, n-protic Brønsted acid (C). The invention further relates to an n-protic Brønsted acid (C) having a degree of protolysis D of 0<D<n, wherein n is the maximum number of transferable protons, with n=2, 3 or 4, and D is the calculated proton fraction of the organic, n-protic Brønsted acid (C).

Abstract: This invention relates to novel macromers containing dithiocarbonate (or xanthate) groups, novel preformed stabilizers comprising macromers, and novel polymer polyols comprising the novel macromers and/or novel preformed stabilizers. This invention also relates to processes for the preparation of these materials. Other aspects of this invention include foams comprising the novel polymer polyols and a process for preparing foam comprising the novel polymer polyols.

Abstract: This invention relates to novel macromers containing dithiocarbonate (or xanthate) groups, novel preformed stabilizers comprising macromers, and novel polymer polyols comprising the novel macromers and/or novel preformed stabilizers. This invention also relates to processes for the preparation of these materials. Other aspects of this invention include foams comprising the novel polymer polyols and a process for preparing foam comprising the novel polymer polyols.

Abstract: The present invention relates to a method for producing a prepolymer that contains carbon-carbon multiple bonds, a polyol component A) being reacted with component B) that contains isocyanate groups and the polyol component comprising a polyether carbonate polyol that contains carbon-carbon multiple bonds.

Abstract: The present invention relates to polyoxazolidinone compounds, a method for the production of polyoxazolidinone compounds, comprising the step of reacting a biscarbamate compound with a bisepoxide compound in the presence of a mono-carbamate, a mono-isocyanate and/or a mono-epoxide compound as chain regulator and a suitable base having a pKb value of ?9 as catalyst. The invention further relates to the use of polyoxazolidinone compounds with high thermal stability.

Abstract: The invention relates to a method for producing polyether carbonate polyols by agglomeration of alkyl oxides and carbon dioxide on carboxylic acid in the presence of a double metal cyanide (DMC) catalyst, wherein one or more carboxylic acids are continually added to the reactor during the reaction, characterized in that the carboxylic acid is at least difunctional and has a pKa value greater than or equal to 1.5, and the adding of the one or more carboxylic acids occurs such that, at any time in the method according to the invention, the molar concentration of unconverted carboxylic acid in the reaction mixture does not exceed a value in the amount of 0.001 mol/g multiplied by the mass of the catalyst used per liter of reaction mixture, specified in grams, and two carboxylic acid groups present in the same molecule are separated from each other at least by one carbon atom. The method further relates to the polyether carbonate polyols obtained according to the invention.

Abstract: The present invention relates to a method for producing polyether carbonates containing alkoxysilyl groups in which (a) an unsaturated polyether carbonate polyol is reacted with (b) an alkoxysilane compound of formula (II) Si(X)m(R1)n(R2)o (II), where X?H, Y—S—H and Y=C1-C22 alkylene, C6-C14 arylene, C7-C14 aralkylene, C7-C14 alkylarylene; R1=C1-C8 alkoxy, C7-C20-aralkoxy, C6-C14 aroxy, C7-C20 alkylaroxy; R2=C1-C22 alkyl, C6-C14 aryl, C7-C14 aralkyl, C7-C14 alkylaryl, and m and n represent, independently of one another, an integer ?1, o is zero or an integer ?1 and m+n+o=4. The invention further relates to the production of a polyurethane polymer using such a polyether carbonate, a cross-linked, siloxane group containing polymer and a molded part containing or consisting of said cross-linked polymer.

Abstract: This invention relates to novel macromers containing dithiocarbonate (or xanthate) groups, novel preformed stabilizers comprising macromers, and novel polymer polyols comprising the novel macromers and/or novel preformed stabilizers. This invention also relates to processes for the preparation of these materials. Other aspects of this invention include foams comprising the novel polymer polyols and a process for preparing foam comprising the novel polymer polyols.

Abstract: The invention provides a process for preparing polyether carbonate polyols by addition of alkylene oxides and carbon dioxide onto H-functional starter substance in the presence of a double metal cyanide (DMC) catalyst or in the presence of a metal complex catalyst based on the metals zinc and/or cobalt, wherein (?) alkylene oxide and carbon dioxide are added onto H-functional starter substance in a reactor in the presence of a double metal cyanide catalyst or in the presence of a metal complex catalyst based on the metals zinc and/or cobalt, wherein a reaction mixture comprising the polyether carbonate polyol is obtained, and wherein (?) the reaction mixture obtained in step (?) remains in the reactor or is transferred continuously into a postreactor, wherein the content of free alkylene oxide in the reaction mixture is reduced in each case in the manner of a postreaction, characterized in that a component K is added during the postreaction, component K being selected from at least one compound containing a p

Abstract: The present invention relates to a process for preparing aromatic polycarbonates, comprising the step of reacting bisphenols with dithiocarbonates or selenium analogs thereof in the presence of a catalyst. It further relates to the use of dithiocarbonates or selenium analogs thereof as transesterifying reagents for the preparation of polycarbonates.

Abstract: The invention relates to a method for producing polyether carbonate polyols, comprising the step of reacting alkylene oxide with carbon dioxide in the presence of an h-functional starter compound and double metal cyanide catalyst. The invention is characterized in that the method comprises the following steps: (?) optionally, pre-treating the double metal cyanide catalyst (DMC catalyst) at a temperature of 50 to 200° C.

Abstract: The invention relates to a method for producing polyether carbonate polyols by agglomeration of alkyl oxides and carbon dioxide on carboxylic acid in the presence of a double metal cyanide (DMC) catalyst, wherein one or more carboxylic acids are continually added to the reactor during the reaction, characterized in that the carboxylic acid is at least difunctional and has a pKa value greater than or equal to 1.5, and the adding of the one or more carboxylic acids occurs such that, at any time in the method according to the invention, the molar concentration of unconverted carboxylic acid in the reaction mixture does not exceed a value in the amount of 0.001 mol/g multiplied by the mass of the catalyst used per liter of reaction mixture, specified in grams, and two carboxylic acid groups present in the same molecule are separated from each other at least by one carbon atom. The method further relates to the polyether carbonate polyols obtained according to the invention.