Patents by Inventor Ernst Schönbrunn

Ernst Schönbrunn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS AND DEGRADERS OF JANUS KINASE 2
    Publication number: 20240140952
    Abstract: The present disclosure provides inhibitors of Janus Kinase 2 (JAK2) which may be used in the treatment of medical disorders such as cancer.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 2, 2024
    Inventors: Nicholas LAWRENCE, Harshani LAWRENCE, Ernst SCHÖNBRUNN, Gary REUTHER
  • BRD4-kinase inhibitors as cancer therapeutics
    Patent number: 11643396
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: May 9, 2023
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • BRD4-JAK2 INHIBITORS
    Publication number: 20220119370
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Application
    Filed: September 9, 2019
    Publication date: April 21, 2022
    Inventors: Ernst SCHÖNBRUNN, Nicholas J. LAWRENCE, Harshani R. LAWRENCE, Gary REUTHER
  • BRD4-JAK2 INHIBITORS
    Publication number: 20210355088
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I, II, and II.
    Type: Application
    Filed: September 9, 2019
    Publication date: November 18, 2021
    Inventors: Ernst SCHÖNBRUNN, Nicholas J. LAWRENCE, Harshani R. LAWRENCE, Gary REUTHER
  • BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
    Publication number: 20200407328
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 31, 2020
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • BRD4-kinase inhibitors as cancer therapeutics
    Patent number: 10738016
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: August 11, 2020
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • Potent dual BRD4-kinase inhibitors as cancer therapeutics
    Patent number: 10526291
    Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: January 7, 2020
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Gary W. Reuther
  • POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
    Publication number: 20190055203
    Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
    Type: Application
    Filed: October 22, 2018
    Publication date: February 21, 2019
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
    Publication number: 20180290984
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Application
    Filed: October 13, 2016
    Publication date: October 11, 2018
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • Aurora kinase inhibitors and methods of making and using thereof
    Patent number: 9597329
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 21, 2017
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin
  • AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20170000787
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Application
    Filed: February 1, 2016
    Publication date: January 5, 2017
    Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin
  • Aurora kinase inhibitors and methods of making and using thereof
    Patent number: 9249124
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 2, 2016
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin
  • AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20140057913
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Application
    Filed: March 30, 2012
    Publication date: February 27, 2014
    Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin