Patents by Inventor Ernst Schonbrunn

Ernst Schonbrunn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TAF1 INHIBITORS
    Publication number: 20240150333
    Abstract: Disclosed are inhibitors for TAF1. The TAF1 inhibitors are compounds having a structure according to one of the Formula described herein. Methods of using the disclosed compounds to treat proliferative disorders are also disclosed.
    Type: Application
    Filed: March 22, 2021
    Publication date: May 9, 2024
    Inventors: Ernst SCHONBRUNN, Justin LOPCHUK, Md Rezaul KARIM, Zachary SHULTZ
  • INHIBITORS AND DEGRADERS OF JANUS KINASE 2
    Publication number: 20240140952
    Abstract: The present disclosure provides inhibitors of Janus Kinase 2 (JAK2) which may be used in the treatment of medical disorders such as cancer.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 2, 2024
    Inventors: Nicholas LAWRENCE, Harshani LAWRENCE, Ernst SCHÖNBRUNN, Gary REUTHER
  • THERAPEUTIC COMPOUNDS AND METHODS
    Publication number: 20240002339
    Abstract: The invention provides a compound of Formula (I): or a salt thereof, wherein R1-R3, R5-R11, Z, X, and L have any of the values described in the specification, as well as compositions comprising a compound of Formula (I). The compounds are useful as cyclin-dependent kinase 2 (CDK2) inhibitors.
    Type: Application
    Filed: June 29, 2023
    Publication date: January 4, 2024
    Inventors: Ingrid Gunda Georg, Timothy Ward, Erik Faber, Jon E. Hawkinson, Nan Wang, Ernst Schonbrunn
  • MERGED SCAFFOLD TAF1 INHIBITORS
    Publication number: 20240002378
    Abstract: Disclosed are inhibitors for TAF1. Methods of using the disclosed compounds to treat cancer are also disclosed.
    Type: Application
    Filed: November 30, 2021
    Publication date: January 4, 2024
    Inventors: Justin M. LOPCHUK, Ernst SCHONBRUNN, Zachary SHULTZ, Md Rezaul KARIM, Jiandong CHEN
  • BRD4-kinase inhibitors as cancer therapeutics
    Patent number: 11643396
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: May 9, 2023
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • BRD4-JAK2 INHIBITORS
    Publication number: 20220119370
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Application
    Filed: September 9, 2019
    Publication date: April 21, 2022
    Inventors: Ernst SCHÖNBRUNN, Nicholas J. LAWRENCE, Harshani R. LAWRENCE, Gary REUTHER
  • BRD4-JAK2 INHIBITORS
    Publication number: 20210355088
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I, II, and II.
    Type: Application
    Filed: September 9, 2019
    Publication date: November 18, 2021
    Inventors: Ernst SCHÖNBRUNN, Nicholas J. LAWRENCE, Harshani R. LAWRENCE, Gary REUTHER
  • BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
    Publication number: 20200407328
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 31, 2020
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • BRD4-kinase inhibitors as cancer therapeutics
    Patent number: 10738016
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: August 11, 2020
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • Potent dual BRD4-kinase inhibitors as cancer therapeutics
    Patent number: 10526291
    Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: January 7, 2020
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Gary W. Reuther
  • POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
    Publication number: 20190055203
    Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
    Type: Application
    Filed: October 22, 2018
    Publication date: February 21, 2019
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS
    Publication number: 20180290984
    Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
    Type: Application
    Filed: October 13, 2016
    Publication date: October 11, 2018
    Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
  • Inhibitors of Rho associated protein kinases (ROCK) and methods of use
    Patent number: 9808447
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: November 7, 2017
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • Aurora kinase inhibitors and methods of making and using thereof
    Patent number: 9597329
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 21, 2017
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin
  • INHIBITORS OF RHO ASSOCIATED PROTEIN KINASES (ROCK) AND METHODS OF USE
    Publication number: 20170049760
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Application
    Filed: August 8, 2016
    Publication date: February 23, 2017
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20170000787
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Application
    Filed: February 1, 2016
    Publication date: January 5, 2017
    Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin
  • Inhibitors of rho associated protein kinases (ROCK) and methods of use
    Patent number: 9409868
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: August 9, 2016
    Assignee: H. Lee Moffin Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • Aurora kinase inhibitors and methods of making and using thereof
    Patent number: 9249124
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 2, 2016
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin
  • INHIBITORS OF RHO ASSOCIATED PROTEIN KINASES (ROCK) AND METHODS OF USE
    Publication number: 20140336440
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Application
    Filed: January 24, 2013
    Publication date: November 13, 2014
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20140057913
    Abstract: Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
    Type: Application
    Filed: March 30, 2012
    Publication date: February 27, 2014
    Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Said M. Sebti, Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence, Matthew P. Martin