Abstract: The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

Abstract: The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

Abstract: In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

Abstract: This invention relates to novel heterocycle compounds including but not limited to 3-?3-?3-(imidazolin-2-yl amino)propyloxy!isoxazol-5-ylcarbonylamino!-2-(benzyloxycarbonylamino)-pro pionic acid, which are useful as antagonists of the .alpha..sub.v .beta..sub.3 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion and the treatment of angiogenic disorders, inflammation, bone degradation, tumors, metastases, thrombosis, and other cell aggregation-related conditions.

Abstract: A one-piece galvanic solid element can be produced by directly polymerizing acetylene onto the surfaces of a disc-shaped ceramic solid electrolyte, using Ziegler-Natta catalysts. Starting from the polyacetylene layers so formed, negative electrode polarity is imparted to one layer and positive electrode polarity to the other layer, through immersion of the element in a suitable doping solution (e.g. NaPF.sub.6 in CH.sub.2 Cl.sub.2) and electrochemical polarization. As electrolyte material there can be used .beta.-Al.sub.2 O.sub.3, and mixed crystal compounds such as Na.sub.3 Zr.sub.2 Si.sub.2 PO.sub.12, which are Na-ion conductive, or Li-ion conductive Li.sub.3 N. Replacement of the negative polyacetylene electrode with Li or Na is possible.

Abstract: The active mass is supported by an antimony free or antimony poor grid having embedded therein antimony-containing storage bodies from which the antimony is released in controlled manner during the life span of the electrode.

Abstract: Lead dust evolution from battery plates is reduced by applying a coating containing a silicate. Also plates so produced.

Abstract: The weight of the negative active mass is below 80% of the positive active mass.Preferably there is one more positive than negative plates.

Abstract: In a galvanic cell, there is provided a solid fluoride ion-conductive electrolyte which is a compound having the formula M.sub.n Pb.sub.1.sub.-n F.sub.2.sub.-n wherein M is at least one element selected from the group consisting of potassium and rubidium; Pb is usually all lead but part of the lead may be replaced by metal more electropositive than lead; F is fluorine; and n is a positive value.