Patents by Inventor Errol DeSouza

Errol DeSouza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamers comprising CPG motifs
    Patent number: 10100316
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: October 16, 2018
    Assignee: Archemix LLC
    Inventors: David Epstein, Dilara Grate, Martin Stanton, John L. Diener, Charles Wilson, Thomas Greene McCauley, Errol Desouza
  • Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
    Publication number: 20040253679
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Application
    Filed: April 21, 2004
    Publication date: December 16, 2004
    Inventors: David Epstein, Dilara Grate, Martin Stanton, John L. Diener, Charles Wilson, Thomas McCauley, Errol DeSouza
  • Isolated nucleic acid encoding corticotropin-releasing factor.sub.2 receptors
    Patent number: 5786203
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF.sub.2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: July 28, 1998
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Errol DeSouza