Patents by Inventor Ervin Epstein
Ervin Epstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170231968Abstract: A method for treating pruritus by topically applying a composition comprising a hedgehog inhibitor compound is provided.Type: ApplicationFiled: February 9, 2017Publication date: August 17, 2017Inventor: Ervin Epstein
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Patent number: 8178298Abstract: Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.Type: GrantFiled: January 11, 2010Date of Patent: May 15, 2012Assignees: The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Jr.
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Publication number: 20100221724Abstract: Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.Type: ApplicationFiled: January 11, 2010Publication date: September 2, 2010Inventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, JR.
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Patent number: 7659371Abstract: Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.Type: GrantFiled: August 20, 2007Date of Patent: February 9, 2010Assignees: The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Jr.
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Patent number: 7465552Abstract: Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.Type: GrantFiled: April 22, 2003Date of Patent: December 16, 2008Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of CaliforniaInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Jr.
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Publication number: 20080300167Abstract: Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.Type: ApplicationFiled: August 20, 2007Publication date: December 4, 2008Applicants: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of CaliforniaInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, JR.
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Patent number: 6946257Abstract: Methods are provided for identifying agents that decrease hedgehog signal transduction for ameliorating an effect of loss of function of a patched gene in a mammalian cell.Type: GrantFiled: August 21, 1997Date of Patent: September 20, 2005Assignees: Regents of the University of California, Board of Trustees of the Leland S. Stanford, Jr. UniversityInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Jr.
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Publication number: 20030186309Abstract: Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.Type: ApplicationFiled: April 22, 2003Publication date: October 2, 2003Applicants: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of CaliforniaInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein
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Patent number: 6551782Abstract: Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.Type: GrantFiled: November 28, 2000Date of Patent: April 22, 2003Assignees: Stanford University, University of CaliforniaInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Jr.
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Patent number: 6429354Abstract: Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. The patched and hedgehog genes are useful: in creating transgenic animal models for these human cancers. The patched nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated 15 physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.Type: GrantFiled: August 22, 1997Date of Patent: August 6, 2002Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of CaliforniaInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Jr.
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Patent number: 6027882Abstract: Methods for isolating patched genes, particularly mammalian patched genes, including mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Loss-of function of the patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. Therefore, methods for using the patched gene as a diagnostic for assessing a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene, are disclosed.Type: GrantFiled: May 31, 1996Date of Patent: February 22, 2000Assignee: The Regents of The University of CaliforniaInventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Tony Oro
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Patent number: 5759811Abstract: A mutation in the human sonic hedgehog gene is associated with tumorigenesis. A variety of human tumors, including basal cell carcinomas, breast carcinomas, medulloblastomas, etc., have a somatic mutation that results in an amino acid substitution at position 133 ?*his133 SHH!, or in a mutation at position 114. Such mutated genes and fragments thereof, encoded protein, and antibodies specific for the mutated protein are useful in characterizing the phenotype of associated tumors. The mutant protein is useful in drug screening for compositions that antagonize or otherwise modulate HH activity or expression. The encoded protein is also used as a therapeutic, to modulate cell proliferation and differentiation, and treatment of pathological conditions associated with decreased hedgehog signaling.Type: GrantFiled: November 13, 1996Date of Patent: June 2, 1998Assignee: The Regents of the University of CaliforniaInventors: Ervin Epstein, Zhilan Hu, Jeanette Bonifas