Patents by Inventor Ervin Fodor

Ervin Fodor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Helper-free Rescue of Recombinant Negative Strand RNA Virus Systems
    Publication number: 20120058538
    Abstract: The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-strand RNA viruses intracellularly in the absence of helper virus from expression vectors comprising cDNAs encoding the viral proteins necessary to form ribonucleoprotein complexes (RNPs) and expression vectors comprising cDNA for genomic viral RNA(s) (vRNAs) or the corresponding cRNA(s). The present invention also relates to methods of generating infectious recombinant negative-strand RNA viruses which have mutations in viral genes and/or which express, package and/or present peptides or polypeptides encoded by heterologous nucleic acid sequences.
    Type: Application
    Filed: October 11, 2011
    Publication date: March 8, 2012
    Inventors: Peter Palese, Adolfo Garcia-Sastre, George G. Brownlee, Ervin Fodor
  • Recombinant negative strand RNA virus expression systems and vaccines
    Publication number: 20090061521
    Abstract: The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-strand RNA viruses intracellularly in the absence of helper virus from expression vectors comprising cDNAs encoding the viral proteins necessary to form ribonucleoprotein complexes (RNPs) and expression vectors comprising cDNA for genomic viral RNA(s) (vRNAs) or the corresponding cRNA(s). The present invention also relates to methods of generating infectious recombinant negative-strand RNA viruses which have mutations in viral genes and/or which express, package and/or present peptides or polypeptides encoded by heterologous nucleic acid sequences.
    Type: Application
    Filed: April 22, 2008
    Publication date: March 5, 2009
    Inventors: Peter Palese, Adolfo Garcia-Sastre, George G. Brownlee, Ervin Fodor
  • Helper-free rescue of recombinant negative strand RNA virus
    Patent number: 7384774
    Abstract: The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-strand RNA viruses intracellularly in the absence of helper virus from expression vectors comprising cDNAs encoding the viral proteins necessary to form ribonucleoprotein complexes (RNPs) and expression vectors comprising cDNA for genomic viral RNA(s) (vRNAs) or the corresponding cRNA(s). The present invention also relates to methods of generating infectious recombinant negative-strand RNA viruses which have mutations in viral genes and/or which express, package and/or present peptides or polypeptides encoded by heterologous nucleic acid sequences.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: June 10, 2008
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: Peter Palese, Adolfo Garcia-Sastre, George G Brownlee, Ervin Fodor
  • Helper-free rescue of recombinant negative strand RNA virus
    Publication number: 20040142003
    Abstract: The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-strand RNA viruses intracellularly in the absence of helper virus from expression vectors comprising cDNAs encoding the viral proteins necessary to form ribonucleoprotein complexes (RNPs) and expression vectors comprising cDNA for genomic viral RNA(s) (vRNAs) or the corresponding cRNA(s). The present invention also relates to methods of generating infectious recombinant negative-strand RNA viruses which have mutations in viral genes and/or which express, package and/or present peptides or polypeptides encoded by heterologous nucleic acid sequences.
    Type: Application
    Filed: August 28, 2003
    Publication date: July 22, 2004
    Applicant: Mt. Sinai School of Medicine of New York University
    Inventors: Peter Palese, Adolfo Garcia-Sastre, George G. Brownlee, Ervin Fodor
  • Helper-free rescue of recombinant negative strand RNA virus
    Patent number: 6649372
    Abstract: The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-strand RNA viruses intracellularly in the absence of helper virus from expression vectors comprising cDNAs encoding the viral proteins necessary to form ribonucleoprotein complexes (RNPs) and expression vectors comprising cDNA for genomic viral RNA(s) (vRNAs) or the corresponding cRNA(s). The present invention also relates to methods of generating infectious recombinant negative-strand RNA viruses which have mutations in viral genes and/or which express, package and/or present peptides or polypeptides encoded by heterologous nucleic acid sequences.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: November 18, 2003
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: Peter Palese, Adolfo Garcia-Sastre, George G. Brownlee, Ervin Fodor