Patents by Inventor Ervin Nagy
Ervin Nagy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11859191Abstract: This disclosure is related to plant-optimized recombinant nucleic acids encoding Cpf1 and their use in planta. Also disclosed are compositions, expression cassettes, and plant cells comprising the recombinant nucleic acids as well as methods and kits for modifying a target sequence in a plant genome using the recombinant nucleic acids.Type: GrantFiled: August 3, 2022Date of Patent: January 2, 2024Assignee: Monsanto Technology LLCInventors: Stanislaw Flasinski, Elysia Krieger, Ervin Nagy, Krishnakumar Sridharan, Xudong Ye
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Publication number: 20230340441Abstract: Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for cleaving a target DNA in eukaryotic cells with a guide RNA capable of hybridizing with a target sequence and an RNA-guided DNA nuclease are provided. Also provided are vectors and vector systems which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR systems.Type: ApplicationFiled: June 5, 2023Publication date: October 26, 2023Applicant: Monsanto Technology LLCInventors: Jaishree M. CHITTOOR, Ervin NAGY, Keith H. TURNER
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Patent number: 11692182Abstract: Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for cleaving a target DNA in eukaryotic cells with a guide RNA capable of hybridizing with a target sequence and an RNA-guided DNA nuclease are provided. Also provided are vectors and vector systems which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR systems.Type: GrantFiled: October 7, 2016Date of Patent: July 4, 2023Assignee: Monsanto Technology LLCInventors: Jaishree Chittoor, Ervin Nagy, Keith H. Turner
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Publication number: 20230193302Abstract: This disclosure is related to plant-optimized recombinant nucleic acids encoding Cpfl and their use in planta. Also disclosed are compositions, expression cassettes, and plant cells comprising the recombinant nucleic acids as well as methods and kits for modifying a target sequence in a plant genome using the recombinant nucleic acids.Type: ApplicationFiled: August 3, 2022Publication date: June 22, 2023Applicant: Monsanto Technology LLCInventors: Stanislaw FLASINSKI, Elysia KRIEGER, Ervin NAGY, Krishnakumar SRIDHARAN, Xudong YE
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Publication number: 20220403401Abstract: The invention provides compositions and methods useful for modulating protein expression in eukaryotic cells. The invention also provides transgenic plants, edited plant cells, plant parts, and seeds comprising depleted or optimized Kozak sequences and methods of their use.Type: ApplicationFiled: June 9, 2022Publication date: December 22, 2022Applicant: MONSANTO TECHNOLOGY LLCInventors: Keith DECKER, Bryan GONTAREK, Natalia IVLEVA, Hong LI, Matthew MARENGO, Ervin NAGY, Brent O'Brien, Qungang QI, Graziana TARAMINO
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Publication number: 20220348942Abstract: The present disclosure relates to compositions and methods related to using the CAST system to provide targeted transposition of desired sequences into plant genomes. Several embodiments relate to a method for producing a megalocus on a plant chromosome comprising: (a) obtaining a plant comprising a first locus, wherein the first locus comprises an endogenous trait locus or a transgene; (b) providing to the plant tnsB, tnsC, tniQ, Cast 2k, a guide nucleic acid and a donor cassette; and (c) selecting a progeny plant produced from step (b) wherein targeted transposition of the donor cassette has occurred at a second locus targeted by the guide nucleic acid, wherein the first and second locus are genetically linked but physically separate.Type: ApplicationFiled: August 5, 2020Publication date: November 3, 2022Applicant: Monsanto Technology LLCInventors: Larry GILBERTSON, Ervin NAGY, Thomas REAM, Linda RYMARQUIS, Xudong YE
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Patent number: 11414669Abstract: This disclosure is related to plant-optimized recombinant nucleic acids encoding Cpf1 and their use in planta. Also disclosed are compositions, expression cassettes, and plant cells comprising the recombinant nucleic acids as well as methods and kits for modifying a target sequence in a plant genome using the recombinant nucleic acids.Type: GrantFiled: September 6, 2019Date of Patent: August 16, 2022Assignee: MONSANTO TECHNOLOGY LLCInventors: Stanislaw Flasinski, Elysia Krieger, Ervin Nagy, Krishnakumar Sridharan, Xudong Ye
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Publication number: 20220162625Abstract: The present disclosure relates to compositions and methods for improving site-directed integration frequency in the genome of plant cells.Type: ApplicationFiled: November 10, 2021Publication date: May 26, 2022Applicant: MONSANTO TECHNOLOGY LLCInventors: John BRADLEY, Larry A. GILBERTSON, Ervin NAGY, Christine SHYU, Peizhen YANG, Xudong YE
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Publication number: 20210380956Abstract: Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for editing genomic DNA in eukaryotic cells with a CRISPR-associated transposase are provided. Also provided are vectors and vector systems which encode one or more CRISPR-associated transposases, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR-associated transposases.Type: ApplicationFiled: April 9, 2021Publication date: December 9, 2021Applicant: MONSANTO TECHNOLOGY LLCInventors: Jaishree M. CHITTOOR, Ervin NAGY
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Publication number: 20210147862Abstract: This invention relates to recombinant nucleic constructs comprising a DNA binding domain, an endonuclease and a reverse transcriptase and methods of use thereof for modifying nucleic acids in plants.Type: ApplicationFiled: October 23, 2020Publication date: May 20, 2021Inventors: Aaron Hummel, Joseph Matthew Watts, Shai Joshua Lawit, Nathaniel Graham, Larry Gilbertson, Ervin Nagy, Linda Rymarquis
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Patent number: 10995327Abstract: Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for editing genomic DNA in eukaryotic cells with a CRISPR-associated transposase are provided. Also provided are vectors and vector systems which encode one or more CRISPR-associated transposases, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR-associated transposases.Type: GrantFiled: December 29, 2016Date of Patent: May 4, 2021Assignee: MONSANTO TECHNOLOGY LLCInventors: Jaishree M. Chittoor, Ervin Nagy
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Publication number: 20200080096Abstract: This disclosure is related to plant-optimized recombinant nucleic acids encoding Cpf1 and their use in planta. Also disclosed are compositions, expression cassettes, and plant cells comprising the recombinant nucleic acids as well as methods and kits for modifying a target sequence in a plant genome using the recombinant nucleic acids.Type: ApplicationFiled: September 6, 2019Publication date: March 12, 2020Applicant: MONSANTO TECHNOLOGY LLCInventors: Stanislaw FLASINSKI, Elysia KRIEGER, Ervin NAGY, Krishna SRIDHARAN, Xudong YE
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Publication number: 20190093090Abstract: Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for editing genomic DNA in eukaryotic cells with a CRISPR-associated transposase are provided. Also provided are vectors and vector systems which encode one or more CRISPR-associated transposases, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR-associated transposases.Type: ApplicationFiled: December 29, 2016Publication date: March 28, 2019Inventors: Jaishree M. CHITTOOR, Ervin NAGY
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Publication number: 20180362943Abstract: Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for cleaving a target DNA in eukaryotic cells with a guide RNA capable of hybridizing with a target sequence and an RNA-guided DNA nuclease are provided. Also provided are vectors and vector systems which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR systems.Type: ApplicationFiled: October 7, 2016Publication date: December 20, 2018Applicant: Monsanto Technology LLCInventors: Jaishree M. Chittoor, Ervin Nagy, Keith H. Turner