Patents by Inventor Erwin W. Gelfand

Erwin W. Gelfand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systemic immune activation method using nucleic acid-lipid complexes
    Publication number: 20040157791
    Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, or an infectious disease. Also disclosed are therapeutic compositions useful in such a method.
    Type: Application
    Filed: February 5, 2004
    Publication date: August 12, 2004
    Inventors: Steven W. Dow, Robyn E. Elmslie, Jurgen Karl Johannes Schwarze, Erwin W. Gelfand
  • Regulation of cytokine production in a hematopoietic cell
    Publication number: 20030129752
    Abstract: A method useful for regulating cytokine production by a hematopoietic cell by regulating an MEKK/JNKK-contingent signal transduction pathway in such a cell is disclosed. Methods of identifying compounds capable of specifically regulating an MEKK/JNKK-contingent signal transduction pathway in hematopoietic cells, a kit for identifying cytokine regulators, methods to treat diseases involving cytokine production, and cells useful in such methods are also set forth.
    Type: Application
    Filed: July 10, 2002
    Publication date: July 10, 2003
    Applicant: National Jewish Center for Immunology and Respiratory Medicine
    Inventors: Erwin W. Gelfand, Gary L. Johnson
  • Method for regulating cell growth and assays related thereto
    Publication number: 20030039998
    Abstract: Disclosed are methods for assessing tumor cell growth in a patient for the diagnosis, monitoring and/or staging of tumor development. The method include the identification of reduced cdk6 expression or biological activity as an indicator of increased cell growth in a cell sample. The methods further include the identification of compounds which regulate cdk6 and the use of such compounds in a method for the regulation of inappropriate cell growth.
    Type: Application
    Filed: May 22, 2002
    Publication date: February 27, 2003
    Applicant: National Jewish Medical & Research Center
    Inventors: Erwin W. Gelfand, Joseph J. Lucas
  • Vaccines using nucleic acid-lipid complexes
    Publication number: 20030022854
    Abstract: This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method.
    Type: Application
    Filed: November 30, 2001
    Publication date: January 30, 2003
    Inventors: Steven W. Dow, Robyn E. Elmslie, Jurgen Karl Johannes Schwarze, Erwin W. Gelfand
  • Regulation of cytokine production in a hematopoietic cell
    Patent number: 6495331
    Abstract: A method useful for regulating cytokine production by a hematopoietic cell by regulating an MEKK/JNKK-contingent signal transduction pathway in such a cell is disclosed. Methods of identifying compounds capable of specifically regulating an MEKK/JNKK-contingent signal transduction pathway in hematopoietic cells, a kit for identifying cytokine regulators, methods to treat diseases involving cytokine production, and cells useful in such methods are also set forth.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: December 17, 2002
    Assignee: National Jewish Center for Immunology and Respiratory Medicine
    Inventors: Erwin W. Gelfand, Gary L. Johnson
  • Method for treating inflammatory diseases using heat shock proteins
    Publication number: 20020006410
    Abstract: This invention relates to a method to protect a mammal from a disease associated with an inflammatory response, and in particular, from an inflammatory disease characterized by eosinophilia, airway hyperresponsiveness and/or a Th2-type immune response. The method includes administration of a heat shock protein to a mammal having such a disease. Formulations useful in the present method are also disclosed.
    Type: Application
    Filed: August 17, 2001
    Publication date: January 17, 2002
    Applicant: Imperial College Innovations Ltd.
    Inventors: Katalin Veronika Lukacs, Angela Francisca Haczku, Erwin W. Gelfand
  • Method to regulate CD40 signaling
    Publication number: 20010055753
    Abstract: The present invention relates to methods useful for identifying compounds capable of specifically controlling CD40 regulation of JNK or p38 activity useful for inhibiting immunoglobulin heavy chain class switching, cytokine production and activation of cells involved in an inflammatory response. The present invention also includes kits to perform such assays and methods to control disease related to such responses.
    Type: Application
    Filed: February 27, 2001
    Publication date: December 27, 2001
    Applicant: National Jewish Medical and Research Center
    Inventors: Erwin W. Gelfand, Gary L. Johnson
  • Method for reducing allergen-induced airway hyperresponsiveness
    Publication number: 20010046955
    Abstract: Disclosed is a method to reduce airway hyperresponsiveness, such as allergen-induced airway hyperresponsiveness, in a mammal by administering an agent that increases the biological activity of a CGRP receptor. Also disclosed are methods for identifying compounds useful in the present method.
    Type: Application
    Filed: March 14, 2001
    Publication date: November 29, 2001
    Inventors: Erwin W. Gelfand, Azzeddine Dakhama
  • Products and processes for regulation of gene recombination
    Patent number: 6187584
    Abstract: This invention generally relates to a novel recombinogenic motif having transposase activities that is important to the regulation and function of Herpes virus replication, V(D)J recombination, and immunoglobulin class switching. The present invention also relates to a site-specific DNA binding region for V(D)J and V(D)J-like recombination signals. Disclosed are identifying characteristics of such motifs as well as methods for identifying the motifs.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: February 13, 2001
    Assignee: National Jewish Medical and Research Center
    Inventors: David H. Dreyfus, Erwin W. Gelfand
  • Method to regulate CD40 signaling
    Patent number: 6132978
    Abstract: The present invention relates to methods useful for identifying compounds capable of specifically controlling CD40 regulation of JNK or p38 activity useful for inhibiting immunoglobulin heavy chain class switching, cytokine production and activation of cells involved in an inflammatory response. The present invention also includes kits to perform such assays and methods to control disease related to such responses.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: October 17, 2000
    Assignee: National Jewish Medical and Research Center
    Inventors: Erwin W. Gelfand, Gary L. Johnson
  • Products and processes for regulation of gene recombination
    Patent number: 5959074
    Abstract: This invention generally relates to a novel recombinogenic motif having transposase activities that is important to the regulation and function of Herpes virus replication, V(D)J recombination, and immunoglobulin class switching. The present invention also relates to a site-specific DNA binding region for V(D)J and V(D)J-like recombination signals. Disclosed are identifying characteristics of such motifs as well as methods for identifying the motifs.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 28, 1999
    Assignee: National Jewish Medical and Research Center
    Inventors: David H. Dreyfus, Erwin W. Gelfand
  • Regulation of cytokine production in a hematopoietic cell
    Patent number: 5910417
    Abstract: A method useful for regulating cytokine production by a hematopoietic cell by regulating an MEKK/JNKK-contingent signal transduction pathway in such a cell is disclosed. Methods of identifying compounds capable of specifically regulating an MEKK/JNKK-contingent signal transduction pathway in hematopoietic cells, a kit for identifying cytokine regulators, methods to treat diseases involving cytokine production, and cells useful in such methods are also set forth.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: June 8, 1999
    Assignee: National Jewish Center for Immunology and Respiratory Medicine
    Inventors: Erwin W. Gelfand, Gary L. Johnson
  • Method for inhibiting virus replication in mammalian cells using carbostyil derivatives
    Patent number: 5670520
    Abstract: A method for inhibiting nucleoside and nucleobase transport in mammalian cells, as well as to a method for inhibition of virus replication, and augmenting phosphorylation of nucleoside analogues, are disclosed, wherein each method uses, as the active agent, a carbostyril derivative.
    Type: Grant
    Filed: March 26, 1996
    Date of Patent: September 23, 1997
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Erwin W. Gelfand, Naohiro Terada
  • Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
    Patent number: 5504093
    Abstract: A method for inhibiting nucleoside and nucleobase transport in mammalian cells, as well as to a method for inhibition of DNA virus replication are disclosed, wherein each method uses, as the active agent, a carbostyril derivative.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: April 2, 1996
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Erwin W. Gelfand, Naohiro Terada