Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.

Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.

Abstract: An automatic sterile sampling system for sampling fluid includes a steam valve, a sampling valve, a processing system, an isolation valve, and a controller. The inner diameters of the valve ports and fluid lines are less than about 8 mm. The system has tapered transitions between an outlet port of the sampling valve and an inlet port of the isolation valve and between a sample transfer port of the isolation valve and a sample transfer channel. An isolation valve drain outlet port protrudes upwardly from the isolation valve and has a longitudinal axis that is angled less than about 45° with from vertical.