Patents by Inventor Eryn Ujita-Lee

Eryn Ujita-Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing secretable glycosyltransferases and other golgi processing enzymes
    Patent number: 5776772
    Abstract: A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a retention signal. The resulting altered enzyme becomes soluble and secretable by the cell without losing its catalytic activity. Secretion of the soluble glycosyltransferase by the cell provides for increased production and simplified recovery of glycosyltransferase.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: July 7, 1998
    Assignee: The Regents of the University of California
    Inventors: James G. Paulson, Eryn Ujita-Lee, Karen J. Colley, Beverly Adler, Jeffrey K. Browne, Jasminder Weinstein
  • Method for producing secretable glycosyltransferases and other golgi processing enzymes
    Patent number: 5541083
    Abstract: A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a retention signal. The resulting altered enzyme becomes soluble and secretable by the cell without losing its catalytic activity. Secretion of the soluble glycosyltransferase by the cell provides for increased production and simplified recovery of glycosyltransferase.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: July 30, 1996
    Assignees: The Regents of the University of California, Amgen
    Inventors: James C. Paulson, Eryn Ujita-Lee, Karen J. Colley, Beverly Adler, Jeffrey K. Browne, Jasminder Weinstein
  • Process for controlling intracellular glycosylation of proteins
    Patent number: 5047335
    Abstract: A process for controlling the glycosylation of protein in a cell wherein the cell is genetically engineered to produce one or more enzymes which provide internal control of the cell's glycosylation mechanism. A Chinese hamster ovary (CHO) cell line is genetically engineered to produce a sialyltransferase. This supplemental sialyltransferase modifies the CHO glycosylation machinery to produce glycoproteins having carbohydrate structures which more closely resemble naturally occurring human glycoproteins.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: September 10, 1991
    Assignee: The Regents of the University of Calif.
    Inventors: James Paulson, Eryn Ujita-Lee, Jasminder Weinstein
  • Method for producing secretable glycosyltransferases and other Golgi processing enzymes
    Patent number: 5032519
    Abstract: A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a rThis invention was made with government support under Grant Contract Nos. GM-27904 and GM-11557 awarded by the National Institute of Health. The government has certain rights in this invention. The publications and other reference materials referred to herein to describe the background of the invention and to provide additional detail regarding its practice are hereby incorporated by reference. For convenience, the reference materials are numerically referenced and grouped in the appended bibliography.
    Type: Grant
    Filed: October 24, 1989
    Date of Patent: July 16, 1991
    Assignee: The Regents of the Univ. of California
    Inventors: James C. Paulson, Eryn Ujita-Lee, Karen J. Colley, Beverly Adler, Jeffrey K. Browne