Patents by Inventor Esa-Matti Lilius

Esa-Matti Lilius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7645591
    Abstract: The present invention relates to differential diagnostics, and provides a method for determining if an infection detected in a patient is of bacterial or of viral origin. In the method chemiluminescence of phagocytic cells induced by non-opsonized zymosan in a blood sample is measured and the expression of Complement Receptor 1 (cr1) is determined. The value when multiplying chemiluminescence with the CR1 expression is compared with method-specific average values for bacterial and viral infections. The invention also provides test kits for accomplishing the method of the invention.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: January 12, 2010
    Inventors: Esa-Matti Lilius, Jari Nuutila
  • Patent number: 6866995
    Abstract: The invention is a method of assessing growth and death rates of micro-organisms within a time period environment of interest. Two reporter genes coding for luminescent and/or fluorescent products introduced into the micro-organism produce at least two products which luminesce or fluoresce. They include, either an essentially stable product produced in an essentially known proportion to the total amount of cells of the micro-organism that are or have been alive within a time period, a product present in an essentially known proportion to the amount of cells alive at any moment within the time period, or an essentially stable product produced in an essentially known proportion to the total amount of cells of the micro-organism that have died within the time period. The micro-organism is incubated and luminescence and/or fluorescence is detected after at time period. Finally, the growth and death rates of the micro-organism are assessed.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: March 15, 2005
    Inventors: Esa-Matti Lilius, Marko Virta
  • Publication number: 20040171013
    Abstract: The present invention relates to differential diagnostics, and provides a method for determining if an infection detected in a parent is of bacterial or of viral origin. In the method chemiluminescence of phagocytic cells induced by non-opsonized zymosan in a blood sample is measured and the expression of Complement Receptor 1 (cr1 is determined. The value when multiplying chemiluminescence with the CR1 expression is compared with method-specific average values for bacterial and viral infections. The invention also provides test kits for accomplishing the method of the invention.
    Type: Application
    Filed: January 14, 2004
    Publication date: September 2, 2004
    Inventors: Esa-Matti Lilius, Jari Nuutila
  • Patent number: 5858690
    Abstract: The present invention comprises a simple way of identifying the tendency towards allergy or allergy already broken out, and showing the probability of allergy in a patient, by measuring the receptor expression of the phagocytic cells of peripheral blood. With a logistic regression model a combination of variables were found which best describe the probability of allergy. Thus the invention relates to a method for detecting allergy and a test kit for accomplishing the method. The invention also relates to a sensitive and specific logistic model for determining the probability of allergy.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: January 12, 1999
    Assignee: Oy Aboatech Ab
    Inventors: Esa-Matti Lilius, Erika Isolauri, Seppo Salminen